Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock

Autor: Alex A Koch, James S Bagnall, Nicola J Smyllie, Nicola Begley, Antony D Adamson, Jennifer L Fribourgh, David G Spiller, Qing-Jun Meng, Carrie L Partch, Korbinian Strimmer, Thomas A House, Michael H Hastings, Andrew SI Loudon

Publikováno v: eLife, Vol 11 (2022)

The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales. We used qu

Externí odkaz: https://doaj.org/article/12909e7319834f59a2d8e05b4469036f

Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock

Autor: James S Bagnall, Alex A Koch, Nicola J Smyllie, Nicola Begley, Antony D Adamson, Jennifer L Fribourgh, David G Spiller, Qing-Jun Meng, Carrie L Partch, Korbinian Strimmer, Thomas A House, Michael H Hastings, Andrew SI Loudon

Publikováno v: Koch, A, Bagnall, J, Smyllie, N J, Begley, N, Adamson, A, Fribourgh, J L, Spiller, D, Meng, Q-J, Partch, C L, Strimmer, K, House, T, Hastings, M H & Loudon, A 2022, ' Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock ', eLife, vol. 11, e73976 . https://doi.org/10.7554/eLife.73976

The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales. We used qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda5ec2b702d72fdf720c555831088b1
https://research.manchester.ac.uk/en/publications/238e144d-a42e-4255-b827-1bca6bd15350