Zobrazeno 1 - 10
of 103
pro vyhledávání: '"James S, Wainscoat"'
Autor:
Marta Fernandez-Mercado, Adam Burns, Andrea Pellagatti, Aristoteles Giagounidis, Ulrich Germing, Xabier Agirre, Felipe Prosper, Carlo Aul, Sally Killick, James S. Wainscoat, Anna Schuh, Jacqueline Boultwood
Publikováno v:
Haematologica, Vol 98, Iss 12 (2013)
Interstitial deletion of chromosome 5q is the most common chromosomal abnormality in myelodysplastic syndromes. The catalogue of genes involved in the molecular pathogenesis of myelodysplastic syndromes is rapidly expanding and next-generation sequen
Externí odkaz:
https://doaj.org/article/030b29d304f54a98bd324671e54b0a26
Autor:
Marta Fernandez-Mercado, Bon Ham Yip, Andrea Pellagatti, Carwyn Davies, María José Larrayoz, Toshinori Kondo, Cristina Pérez, Sally Killick, Emma-Jane McDonald, María Dolores Odero, Xabier Agirre, Felipe Prósper, María José Calasanz, James S Wainscoat, Jacqueline Boultwood
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42334 (2012)
Acute myeloid leukemia patients with normal cytogenetics (CN-AML) account for almost half of AML cases. We aimed to study the frequency and relationship of a wide range of genes previously reported as mutated in AML (ASXL1, NPM1, FLT3, TET2, IDH1/2,
Externí odkaz:
https://doaj.org/article/6cfaed15b9bf4c11b08ee7dfcacf1fde
Autor:
Cristina Pérez, Nicolas Martínez-Calle, José Ignacio Martín-Subero, Victor Segura, Eric Delabesse, Marta Fernandez-Mercado, Leire Garate, Sara Alvarez, José Rifon, Sara Varea, Jacqueline Boultwood, James S Wainscoat, Juan Cruz Cigudosa, María José Calasanz, Nicholas C P Cross, Felipe Prósper, Xabier Agirre
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31605 (2012)
Chronic myelomonocytic leukemia (CMML) has recently been associated with a high incidence of diverse mutations in genes such as TET2 or EZH2 that are implicated in epigenetic mechanisms. We have performed genome-wide DNA methylation arrays and mutati
Externí odkaz:
https://doaj.org/article/80cfbf2c29534d38afa827a41152cd75
Autor:
Erica Ballabio, Regina Regan, Elisa Garimberti, Jochen Harbott, Jutta Bradtke, Andrea Teigler-Schlegel, Andrea Biondi, Giovanni Cazzaniga, Giovanni Giudici, James S Wainscoat, Jacqueline Boultwood, Joanna M Bridger, Samantha J L Knight, Sabrina Tosi
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20607 (2011)
Leukaemia is often associated with genetic alterations such as translocations, amplifications and deletions, and recurrent chromosome abnormalities are used as markers of diagnostic and prognostic relevance. However, a proportion of acute myeloid leu
Externí odkaz:
https://doaj.org/article/20d196a998a84cfb97abb260fc0fc215
Autor:
Martin Jädersten, Leonie Saft, Andrea Pellagatti, Gudrun Göhring, James S. Wainscoat, Jacqueline Boultwood, Anna Porwit, Brigitte Schlegelberger, Eva Hellström-Lindberg
Publikováno v:
Haematologica, Vol 94, Iss 12 (2009)
Clonal heterogeneity has not been described in patients with myelodysplastic syndrome with isolated del(5q), for which lenalidomide has emerged as a highly potent treatment. However, transformation to acute myeloid leukemia is occasionally observed,
Externí odkaz:
https://doaj.org/article/ef0227ece87e4b6f8a7166475140502e
Autor:
Li Wang, Carrie Fidler, Nandita Nadig, Aristoteles Giagounidis, Matteo G. Della Porta, Luca Malcovati, Sally Killick, Norbert Gattermann, Carlo Aul, Jacqueline Boultwood, James S. Wainscoat
Publikováno v:
Haematologica, Vol 93, Iss 7 (2008)
Background We undertook a genome wide single nucleotide polymorphism analysis of a spectrum of patients with myelodysplastic syndrome del(5q) in order to investigate whether additional genomic abnormalities occur. Single nucleotide polymorphism array
Externí odkaz:
https://doaj.org/article/07260042ef0242998c48c27475d46dfb
Autor:
Jacqueline Boultwood, Andrea Pellagatti, Maryam Nikpour, Beena Pushkaran, Carrie Fidler, Helen Cattan, Tim J Littlewood, Luca Malcovati, Matteo G Della Porta, Martin Jädersten, Sally Killick, Aristoteles Giagounidis, David Bowen, Eva Hellström-Lindberg, Mario Cazzola, James S Wainscoat
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1970 (2008)
Refractory Anemia with Ring Sideroblasts (RARS) is an acquired myelodysplastic syndrome (MDS) characterized by an excess iron accumulation in the mitochondria of erythroblasts. The pathogenesis of RARS and the cause of this unusual pattern of iron de
Externí odkaz:
https://doaj.org/article/581e1ece6d7149f982eab9948ed2d2a0
Autor:
Simon Moule, Ruth Clifford, Adam J. Mead, Michelle Rugless, Petter S. Woll, D Atkinson, Shirley Henderson, Anna Schuh, Nicola Bienz, Sten Eirik W. Jacobsen, James S. Wainscoat, Paresh Vyas
Abstract 1738 Since the initial description of V617F somatic mutation in patients with Philadelphia chromosome negative myeloproliferative neoplasms (MPNs), a remarkable association between alterations in the JAK2 gene and MPNs has emerged. In additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b034e86919a36d0925b6caf2016f5d25
https://ora.ox.ac.uk/objects/uuid:e50e82ac-2ead-4101-b5f6-fdc100960634
https://ora.ox.ac.uk/objects/uuid:e50e82ac-2ead-4101-b5f6-fdc100960634
Autor:
Simona Conte, Sudhir Tauro, Jacqueline Boultwood, Erica Travaglino, Peter J. Campbell, Michael J. Groves, Norene Keenan, Eva Hellström-Lindberg, Elli Papaemmanuil, Anna L. Godfrey, Mario Cazzola, P. Andrew Futreal, Jonathan Hinton, Ann Hyslop, Cristiana Pascutto, Ilaria Ambaglio, Matteo G. Della Porta, Luca Malcovati, James S. Wainscoat, Anna Gallì, Matteo Claudio Da Via, David T. Bowen, Michael R. Stratton, Laura Mudie
In a previous study, we identified somatic mutations of SF3B1, a gene encoding a core component of RNA splicing machinery, in patients with myelodysplastic syndrome (MDS). Here, we define the clinical significance of these mutations in MDS and myelod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf688117f0ac580792b39f9cfdfbfbd4
https://doi.org/10.1182/blood-2011-09-377275
https://doi.org/10.1182/blood-2011-09-377275