Zobrazeno 1 - 10
of 178
pro vyhledávání: '"James S, Nowick"'
Autor:
Adam G. Kreutzer, Chelsea Marie T. Parrocha, Sepehr Haerianardakani, Gretchen Guaglianone, Jennifer T. Nguyen, Michelle N. Diab, William Yong, Mari Perez-Rosendahl, Elizabeth Head, James S. Nowick
Publikováno v:
ACS Central Science, Vol 10, Iss 1, Pp 104-121 (2023)
Externí odkaz:
https://doaj.org/article/098b29bada2f49a389917a993817e744
Autor:
Paul Joshua Hurst, Michael A. Morris, Annissa A. Graham, James S. Nowick, Joseph P. Patterson
Publikováno v:
ACS Omega, Vol 6, Iss 41, Pp 27412-27417 (2021)
Externí odkaz:
https://doaj.org/article/dbf5a3b124884eada768d941664cb1d9
Autor:
Maj Krumberger, Xingyue Li, Adam G. Kreutzer, Aaron J. Peoples, Anthony G. Nitti, Andrew M. Cunningham, Chelsea R. Jones, Catherine Achorn, Losee L. Ling, Dallas E. Hughes, James S. Nowick
Publikováno v:
The Journal of Organic Chemistry. 88:2214-2220
Autor:
Adam G. Kreutzer, Gretchen Guaglianone, Stan Yoo, Chelsea Marie T. Parrocha, Sarah M. Ruttenberg, Ryan J. Malonis, Karen Tong, Yu-Fu Lin, Jennifer T. Nguyen, William J. Howitz, Michelle N. Diab, Imane L. Hamza, Jonathan R. Lai, Vicki H. Wysocki, James S. Nowick
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The assembly of the β-amyloid peptide (Aβ) to form oligomers and fibrils is closely associated with the pathogenesis and progression of Alzheimer’s disease. Aβ is a shape-shifting peptide capable of adopting many conformations and folds within t
Autor:
Kate J. McKnelly, Adam G. Kreutzer, William J. Howitz, Katelyn Haduong, Stan Yoo, Candace Hart, James S. Nowick
Publikováno v:
Biochemistry
Familial Alzheimer's disease (FAD) is associated with mutations in the β-amyloid peptide (Aβ) or the amyloid precursor protein (APP). FAD mutations of Aβ were incorporated into a macrocyclic peptide that mimics a β-hairpin to study FAD point muta
Autor:
William J. Howitz, Gretchen Guaglianone, Kate J. McKnelly, Katelyn Haduong, Shareen N. Ashby, Mohamed Laayouni, James S. Nowick
Publikováno v:
ACS Chem Neurosci
This work probes the role of charge in the oligomeric assembly, toxicity, and membrane destabilization of a series of peptides derived from Aβ and the E22Q and E22K familial mutants. In the mutant Aβ peptides, an acidic residue (E) is replaced with
Autor:
Sheng Zhang, Stan Yoo, Dalton T. Snyder, Benjamin B. Katz, Amy Henrickson, Borries Demeler, Vicki H. Wysocki, Adam G. Kreutzer, James S. Nowick
Publikováno v:
Biochemistry
Aβ dimers are a basic building block of many larger Aβ oligomers and are among the most neurotoxic and pathologically relevant species in Alzheimer’s disease. Homogeneous Aβ dimers are difficult to prepare, characterize and study, because Aβ fo
Autor:
Michael A. Morris, Alexander Vallmitjana, Fabian Grein, Tanja Schneider, Melina Arts, Chelsea R. Jones, Betty T. Nguyen, Mohammad H. Hashemian, Melody Malek, Enrico Gratton, James S. Nowick
Publikováno v:
Chemical Science. 13:7747-7754
FRET microscopy experiments demonstrate supramolecular assembly of teixobactin molecules on Bacillus subtilis, providing further evidence that teixobactin is a supramolecular antibiotic.
Publikováno v:
Methods Enzymol
Methods in Enzymology ISBN: 9780323952675
Methods in Enzymology ISBN: 9780323952675
Teixobactin is a promising new antibiotic that kills a spectrum of Gram-positive pathogens that are considered to be urgent threats by the CDC and the WHO. Better understanding of the novel mechanism of action of teixobactin may assist in developing
Publikováno v:
Angew Chem Int Ed Engl
Although β-hairpins are widespread in proteins, there is still no universal tool to coax any small peptide to adopt a β-hairpin conformation, regardless of sequence. Here, we report that δ-linked γ(R)-methyl-ornithine ((δ)MeOrn) provides an impr