Zobrazeno 1 - 10
of 160
pro vyhledávání: '"James S, Nowick"'
Autor:
Adam G. Kreutzer, Chelsea Marie T. Parrocha, Sepehr Haerianardakani, Gretchen Guaglianone, Jennifer T. Nguyen, Michelle N. Diab, William Yong, Mari Perez-Rosendahl, Elizabeth Head, James S. Nowick
Publikováno v:
ACS Central Science, Vol 10, Iss 1, Pp 104-121 (2023)
Externí odkaz:
https://doaj.org/article/098b29bada2f49a389917a993817e744
Autor:
Paul Joshua Hurst, Michael A. Morris, Annissa A. Graham, James S. Nowick, Joseph P. Patterson
Publikováno v:
ACS Omega, Vol 6, Iss 41, Pp 27412-27417 (2021)
Externí odkaz:
https://doaj.org/article/dbf5a3b124884eada768d941664cb1d9
Autor:
Maj Krumberger, Xingyue Li, Adam G. Kreutzer, Aaron J. Peoples, Anthony G. Nitti, Andrew M. Cunningham, Chelsea R. Jones, Catherine Achorn, Losee L. Ling, Dallas E. Hughes, James S. Nowick
Publikováno v:
The Journal of Organic Chemistry. 88:2214-2220
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a2d64a5ff0558a29948aa18a37f16a0
https://doi.org/10.1021/acs.joc.2c02648
https://doi.org/10.1021/acs.joc.2c02648
Autor:
Adam G. Kreutzer, Gretchen Guaglianone, Stan Yoo, Chelsea Marie T. Parrocha, Sarah M. Ruttenberg, Ryan J. Malonis, Karen Tong, Yu-Fu Lin, Jennifer T. Nguyen, William J. Howitz, Michelle N. Diab, Imane L. Hamza, Jonathan R. Lai, Vicki H. Wysocki, James S. Nowick
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The assembly of the β-amyloid peptide (Aβ) to form oligomers and fibrils is closely associated with the pathogenesis and progression of Alzheimer’s disease. Aβ is a shape-shifting peptide capable of adopting many conformations and folds within t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8a8b8c19344edb7a9eb68d6eb71519
https://doi.org/10.1073/pnas.2219216120
https://doi.org/10.1073/pnas.2219216120
Autor:
Kate J. McKnelly, Adam G. Kreutzer, William J. Howitz, Katelyn Haduong, Stan Yoo, Candace Hart, James S. Nowick
Publikováno v:
Biochemistry
Familial Alzheimer's disease (FAD) is associated with mutations in the β-amyloid peptide (Aβ) or the amyloid precursor protein (APP). FAD mutations of Aβ were incorporated into a macrocyclic peptide that mimics a β-hairpin to study FAD point muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe4f4568fc6c37a70d408872061f460
https://doi.org/10.1021/acs.biochem.1c00664
https://doi.org/10.1021/acs.biochem.1c00664
Autor:
William J. Howitz, Gretchen Guaglianone, Kate J. McKnelly, Katelyn Haduong, Shareen N. Ashby, Mohamed Laayouni, James S. Nowick
Publikováno v:
ACS Chem Neurosci
This work probes the role of charge in the oligomeric assembly, toxicity, and membrane destabilization of a series of peptides derived from Aβ and the E22Q and E22K familial mutants. In the mutant Aβ peptides, an acidic residue (E) is replaced with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed260d9ba82790ae5fcfa6f1d5d66da2
https://doi.org/10.1021/acschemneuro.1c00833
https://doi.org/10.1021/acschemneuro.1c00833
Autor:
Sheng Zhang, Stan Yoo, Dalton T. Snyder, Benjamin B. Katz, Amy Henrickson, Borries Demeler, Vicki H. Wysocki, Adam G. Kreutzer, James S. Nowick
Publikováno v:
Biochemistry
Aβ dimers are a basic building block of many larger Aβ oligomers and are among the most neurotoxic and pathologically relevant species in Alzheimer’s disease. Homogeneous Aβ dimers are difficult to prepare, characterize and study, because Aβ fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b49822f3892b4184723f6adea105be
https://doi.org/10.1021/acs.biochem.1c00739
https://doi.org/10.1021/acs.biochem.1c00739
Autor:
Michael A. Morris, Alexander Vallmitjana, Fabian Grein, Tanja Schneider, Melina Arts, Chelsea R. Jones, Betty T. Nguyen, Mohammad H. Hashemian, Melody Malek, Enrico Gratton, James S. Nowick
Publikováno v:
Chemical Science. 13:7747-7754
FRET microscopy experiments demonstrate supramolecular assembly of teixobactin molecules on Bacillus subtilis, providing further evidence that teixobactin is a supramolecular antibiotic.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e689aa62d763a724970fd16f82e87d1
https://doi.org/10.1039/d2sc01388f
https://doi.org/10.1039/d2sc01388f
Publikováno v:
Methods Enzymol
Methods in Enzymology ISBN: 9780323952675
Methods in Enzymology ISBN: 9780323952675
Teixobactin is a promising new antibiotic that kills a spectrum of Gram-positive pathogens that are considered to be urgent threats by the CDC and the WHO. Better understanding of the novel mechanism of action of teixobactin may assist in developing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a6522d834ce83f5401f56ffc2f60a4
https://pubmed.ncbi.nlm.nih.gov/35379436
https://pubmed.ncbi.nlm.nih.gov/35379436
Publikováno v:
Angew Chem Int Ed Engl
Although β-hairpins are widespread in proteins, there is still no universal tool to coax any small peptide to adopt a β-hairpin conformation, regardless of sequence. Here, we report that δ-linked γ(R)-methyl-ornithine ((δ)MeOrn) provides an impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099645a472d828764e99b51b38a4e661
https://doi.org/10.1002/anie.202105559
https://doi.org/10.1002/anie.202105559