Zobrazeno 1 - 10
of 435
pro vyhledávání: '"James S, McCarthy"'
Autor:
Azrin N. Abd-Rahman, Daniel Kaschek, Anne Kümmel, Rebecca Webster, Adam J. Potter, Anand Odedra, Stephen D. Woolley, Stacey Llewellyn, Lachlan Webb, Louise Marquart, Stephan Chalon, Myriam El Gaaloul, James S. McCarthy, Jörg J. Möhrle, Bridget E. Barber
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background The combination antimalarial artefenomel-piperaquine failed to achieve target efficacy in a phase 2b study in Africa and Vietnam. We retrospectively evaluated whether characterizing the pharmacological interaction of this antimala
Externí odkaz:
https://doaj.org/article/1ad787d5bda644748f24b01ed0c73bbd
Autor:
Reena Mukhiya, Wim A. Fleischmann, Jessica R. Loughland, Jo-Anne Chan, Fabian de Labastida Rivera, Dean Andrew, James G. Beeson, James S. McCarthy, Bridget E. Barber, J. Alejandro Lopez, Christian Engwerda, Richard Thomson-Luque, Michelle J. Boyle
Publikováno v:
EBioMedicine, Vol 109, Iss , Pp 105419- (2024)
Summary: Background: Human immune responses to infection and vaccination are heterogenous, driven by multiple factors including genetics, environmental exposures and personal infection histories. For malaria caused by Plasmodium falciparum parasites,
Externí odkaz:
https://doaj.org/article/61b334fc1a284054a6f4ac3e995a4b50
Autor:
Stephen Muhi, Daniel P. O'Brien, Julia L. Marshall, Gayle Ross, Paul D.R. Johnson, Laura K. Mackay, Anand Ramakrishnan, James S. McCarthy, Marcel Doerflinger, Euzebiusz Jamrozik, Timothy P. Stinear, Joshua Osowicki
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Critical knowledge gaps have impeded progress towards reducing the global burden of disease due to Mycobacterium ulcerans, the cause of the neglected tropical disease Buruli ulcer (BU). Development of a controlled human infection model of BU has been
Externí odkaz:
https://doaj.org/article/c3b3819748b94938bdc0ba761aa200a3
Autor:
Stephen Muhi, Daniel P. O'Brien, Julia L. Marshall, Gayle Ross, Paul D.R. Johnson, Laura K. Mackay, Anand Ramakrishnan, James S. McCarthy, Marcel Doerflinger, Euzebiusz Jamrozik, Timothy P. Stinear, Joshua Osowicki
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Critical knowledge gaps have impeded progress towards reducing the global burden of disease due to Mycobacterium ulcerans, the cause of the neglected tropical disease Buruli ulcer (BU). Development of a controlled human infection model of BU has been
Externí odkaz:
https://doaj.org/article/edc943f8fc3e49d9b390671211b87caf
Autor:
Annemiek H J Schutte, Rob Koelewijn, Sitara S R Ajjampur, Bruno Levecke, James S McCarthy, Rojelio Mejia, Steven A Williams, Jaco J Verweij, Lisette van Lieshout, Jaap J van Hellemond
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 8, p e0012404 (2024)
BackgroundInfections with soil-transmitted helminths (STH) and schistosomiasis (SCH) result in a significant global health burden, particularly in rural communities in low and middle-income countries. While microscopy remains the primary diagnostic m
Externí odkaz:
https://doaj.org/article/7f5725ef41f9495ea9385c3edf0703db
Autor:
Stephen D. Woolley, Matthew J. Grigg, Louise Marquart, Jeremy S.E. Gower, Kim Piera, Arya Sheela Nair, Fiona M. Amante, Giri S. Rajahram, Timothy William, David M. Frazer, Stephan Chalon, James S. McCarthy, Nicholas M. Anstey, Bridget E. Barber
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105189- (2024)
Summary: Background: The interaction between iron status and malaria is incompletely understood. We evaluated longitudinal changes in iron homeostasis in volunteers enrolled in malaria volunteer infection studies (VIS) and in Malaysian patients with
Externí odkaz:
https://doaj.org/article/cacdf27f70df4dd7b2ca25c9e1760fa9
Autor:
Pengxing Cao, Steven Kho, Matthew J. Grigg, Bridget E. Barber, Kim A. Piera, Timothy William, Jeanne R. Poespoprodjo, Ihn Kyung Jang, Julie A. Simpson, James M. McCaw, Nicholas M. Anstey, James S. McCarthy, Sumudu Britton
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Plasmodium vivax lactate dehydrogenase (PvLDH) is an essential enzyme in the glycolytic pathway of P. vivax. It is widely used as a diagnostic biomarker and a measure of total-body parasite biomass in vivax malaria. However, the dynamics of
Externí odkaz:
https://doaj.org/article/d48ba3507e1249c79abee4305c434258
Autor:
Leon E. Hugo, Karla van Huyssteen, Olamide Oloniniyi, Laura Donnelly, Anna Conn, Katharine A. Collins, Hayley Mitchell, James S. McCarthy, Joanne Macdonald
Publikováno v:
Frontiers in Tropical Diseases, Vol 5 (2024)
Vector surveillance of Plasmodium falciparum is critical for monitoring and reducing one of the most severe forms of malaria, which causes high morbidity and mortality in children under five and pregnant women. Here we developed a rapid and highly se
Externí odkaz:
https://doaj.org/article/a1515f859bd7412e8fc14f64129abd1d
Autor:
Yulin Wang, Fabian De Labastida Rivera, Chelsea L. Edwards, Teija C.M. Frame, Jessica A. Engel, Luzia Bukali, Jinrui Na, Susanna S. Ng, Dillon Corvino, Marcela Montes de Oca, Patrick T. Bunn, Megan S.F. Soon, Dean Andrew, Jessica R. Loughland, Jia Zhang, Fiona H. Amante, Bridget E. Barber, James S. McCarthy, J. Alejandro Lopez, Michelle J. Boyle, Christian R. Engwerda
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
The development of highly effective malaria vaccines and improvement of drug-treatment protocols to boost antiparasitic immunity are critical for malaria elimination. However, the rapid establishment of parasite-specific immune regulatory networks fo
Externí odkaz:
https://doaj.org/article/3c2a3ba4c5594fffbb78ac8fa7298d0d
Autor:
Louise Marquart, Lachlan Webb, Peter O’Rourke, Michelle L. Gatton, Michelle S. Hsiang, Michael Kalnoky, Ihn Kyung Jang, Henry Ntuku, Davis R. Mumbengegwi, Gonzalo J. Domingo, James S. McCarthy, Sumudu Britton
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-14 (2022)
Abstract Background Rapid diagnostic tests (RDTs) that rely on the detection of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) have become key tools for diagnosing P. falciparum infection. The utility of RDTs can be limited by PfHRP2 persist
Externí odkaz:
https://doaj.org/article/8dbdd9c250114c5f9396a230f669f8e5