Zobrazeno 1 - 2
of 2
pro vyhledávání: '"James Ross Walker"'
Autor:
Deepa Pookot, Scott Jacobson, John M. Ketcham, David Chian, Emily Karbarz, Dennis X. Hu, James Ross Walker, Gene Cutler, Ashkaan Younai, Mikhail Zibinsky, Raymond Diokno, David J. Wustrow, Betty Abraham, Angela Wadsworth, Maureen Kay Reilly, Cesar Meleza, Jenny McKinnell, Jeffrey J. Jackson, Abood Okal, Paul D. Kassner, Lisa A. Marshall, Oezcan Talay, Berenger Biannic, Bui Minna H T, Hilary Plake Beck, Hunter P. Shunatona, Omar Robles
Publikováno v:
Journal of Medicinal Chemistry. 62:6190-6213
Recruitment of suppressive CD4+ FOXP3+ regulatory T cells (Treg) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in patients receiving treatment with immuno-oncology (IO) agents. Human Treg express CCR4 and can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31c664d1b35dae60b88d59898f44ef53
https://doi.org/10.1021/acs.jmedchem.9b00506
https://doi.org/10.1021/acs.jmedchem.9b00506
Autor:
Jan Melom, Mikhail Zibinsky, Nick Shah, Hunter P. Shunatona, Maureen Kay Reilly, Jenny McKinnell, Jordan S. Fridman, Jay P. Powers, Pia Bjork, Juan C. Jaen, Hilary Plake Beck, James Ross Walker, Maksim Osipov, Adam Park, Matthew J. Walters, Rajkumar Noubade, David Chian, Stephen W. Young, Lisa A. Marshall
Publikováno v:
Cancer Research. 75:4290-4290
The IDO1 pathway has been proposed to mediate immunosuppressive effects in the tumor microenvironment through its role in the catabolism of tryptophan, resulting in effects on the differentiation and proliferation of T cells. IDO1 inhibition has show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc74ef9a042ad4b047fa624f482da031
https://doi.org/10.1158/1538-7445.am2015-4290
https://doi.org/10.1158/1538-7445.am2015-4290