Zobrazeno 1 - 5
of 5
pro vyhledávání: '"James Robert Hartnett"'
Autor:
Matthew B. Robers, Ce Shi, Keith V. Wood, Kristopher Zimmerman, Marie K. Schwinn, James Robert Hartnett, Melanie Dart, Thomas Machleidt, Michael P Killoran, Emily Jost, Jennifer Wilkinson, Thomas A. Kirkland
Publikováno v:
ACS medicinal chemistry letters. 9(6)
Protein thermal shift assays (TSAs) provide a means for characterizing target engagement through ligand-induced thermal stabilization. Although these assays are widely utilized for screening libraries and validating hits in drug discovery programs, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc6ac143d89546b3bfee2252e1b9461
https://pubmed.ncbi.nlm.nih.gov/29937980
https://pubmed.ncbi.nlm.nih.gov/29937980
Autor:
Carina Glas, Kristin G. Huwiler, Thomas A. Kirkland, Kristopher Zimmerman, James D Vasta, Cesear Corona, Stefan Knapp, Chad Zimprich, Matthew B. Robers, Ke Ding, Paul Otto, Frank Fan, Susanne Müller, James Robert Hartnett, Thomas Machleidt, Benedict-Tilman Berger, Jennifer Wilkinson, Keith V. Wood, David H. Drewry, Poncho Meisenheimer, Kilian Huber, Carrow I. Wells, Mei Cong, Thomas Hanke, Morgan R. Ingold, Timothy M. Willson, Rachel Friedman Ohana, Michael R. Slater
Publikováno v:
Cell Chemical Biology
Summary For kinase inhibitors, intracellular target selectivity is fundamental to pharmacological mechanism. Although a number of acellular techniques have been developed to measure kinase binding or enzymatic inhibition, such approaches can fail to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc8d115cc6a4e1bbbbadcb2b8ee032a
https://doi.org/10.1016/j.chembiol.2017.10.010
https://doi.org/10.1016/j.chembiol.2017.10.010
Autor:
Paul Otto, Danette L. Daniels, Kate Zhao, Monika G. Wood, Mark McDougall, Dieter Klaubert, Georgyi V. Los, Sarah Wheeler, James Robert Hartnett, Natasha Karassina, Jami English, Chad Zimprich, Nancy Murphy, Jacqui Méndez, Robert F. Bulleit, Pete Stecha, Keith V. Wood, Robin Hurst, Kris Zimmerman, Randall D. Learish, Hélène A Benink, Gediminas Vidugiris, Marjeta Urh, Aldis Darzins, Michael R. Slater, Rachel Friedman Ohana, Lance P. Encell
Publikováno v:
Current Chemical Genomics
Our fundamental understanding of proteins and their biological significance has been enhanced by genetic fusion tags, as they provide a convenient method for introducing unique properties to proteins so that they can be examinedin isolation. Commonly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba84480023d119ed3f0274fd4ecd399
https://doi.org/10.2174/1875397301206010055
https://doi.org/10.2174/1875397301206010055
Autor:
Mei Cong, Matthew B. Robers, Monika G. Wood, Kevin Kupcho, Keith V. Wood, James Robert Hartnett, Sergiy Levin, Thomas A. Kirkland, Danette L. Daniels, Carolyn C. Woodroofe, Andrew L. Niles, Melanie Dart, Kristopher Zimmerman, Thomas Machleidt, Chad Zimprich, Rachel Friedman Ohana, Yi-Qiang Cheng, Michael R. Slater
Publikováno v:
Nature Communications
The therapeutic action of drugs is predicated on their physical engagement with cellular targets. Here we describe a broadly applicable method using bioluminescence resonance energy transfer (BRET) to reveal the binding characteristics of a drug with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16129acbaa5af847dd39d9c7736dbc2f
http://europepmc.org/articles/PMC4686764
http://europepmc.org/articles/PMC4686764
Autor:
Robin Hurst, Terry L. Riss, Andrew L. Niles, John Shultz, Wenhui Zhou, Kevin Kupcho, James Robert Hartnett
Publikováno v:
Toxicology Letters. 258:S56
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7896300c737ee9d2def4497f217bed67
https://doi.org/10.1016/j.toxlet.2016.06.1296
https://doi.org/10.1016/j.toxlet.2016.06.1296