Zobrazeno 1 - 10
of 21
pro vyhledávání: '"James Reigle"'
Autor:
Sinead M. O’Donovan, Ali Imami, Hunter Eby, Nicholas D. Henkel, Justin Fortune Creeden, Sophie Asah, Xiaolu Zhang, Xiaojun Wu, Rawan Alnafisah, R. Travis Taylor, James Reigle, Alexander Thorman, Behrouz Shamsaei, Jarek Meller, Robert E. McCullumsmith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The COVID-19 pandemic caused by the novel SARS-CoV-2 is more contagious than other coronaviruses and has higher rates of mortality than influenza. Identification of effective therapeutics is a crucial tool to treat those infected with SARS-C
Externí odkaz:
https://doaj.org/article/183b0c4e766e453cac438874bd544e5b
Autor:
Rawan S. Alnafisah, James Reigle, Mahmoud Ali Eladawi, Sinead M. O’Donovan, Adam J. Funk, Jaroslaw Meller, Robert E. Mccullumsmith, Rammohan Shukla
Publikováno v:
Neuropsychopharmacology. 47:2033-2041
Antipsychotic drugs (APDs) are effective in treating positive symptoms of schizophrenia (SCZ). However, they have a substantial impact on postmortem studies. As most cohorts lack samples from drug-naive patients, many studies, rather than understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbd539274ef7611500d539e19d21e4b
https://doi.org/10.1038/s41386-022-01310-8
https://doi.org/10.1038/s41386-022-01310-8
Autor:
Rita Verma, Parul Aggarwal, Megan E. Bischoff, James Reigle, Dina Secic, Collin Wetzel, Katherine VandenHeuvel, Jacek Biesiada, Birgit Ehmer, Julio A. Landero Figueroa, David R. Plas, Mario Medvedovic, Jarek Meller, Maria F. Czyzyk-Krzeska
Publikováno v:
Journal of Biological Chemistry. 299:104663
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4077cb2b00cd5f1debf4f49805d3aa4
https://doi.org/10.1016/j.jbc.2023.104663
https://doi.org/10.1016/j.jbc.2023.104663
Autor:
Hunter M. Eby, Rawan Alnafisah, James Reigle, Alexander William Thorman, Behrouz Shamsaei, Nicholas D. Henkel, Xiaolu Zhang, Xiaojun Wu, Sophie Asah, Justin F. Creeden, Jarek Meller, Ali S Imami, R. Travis Taylor, Sinead M. O’Donovan, Robert E. McCullumsmith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
The COVID-19 pandemic caused by the novel SARS-CoV-2 is more contagious than other coronaviruses and has higher rates of mortality than influenza. Identification of effective therapeutics is a crucial tool to treat those infected with SARS-CoV-2 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f696d2818b7b1928d9a66739c247c4
https://doaj.org/article/183b0c4e766e453cac438874bd544e5b
https://doaj.org/article/183b0c4e766e453cac438874bd544e5b
Autor:
Rita Verma, Parul Aggarwal, James Reigle, Dina Secic, Collin Wetzel, Megan E. Bischoff, Katherine VandenHeuvel, Jacek Biesiada, Birgit Ehmer, Julio A. Landero Figueroa, David R. Plas, Mario Medvedovic, Jarek Meller, Maria F. Czyzyk-Krzeska
MAP1LC3C (LC3C) is a member of the microtubule associated family of proteins that are essential in the formation of autophagosomes and lysosomal degradation of cargo. LC3C has tumor suppressing activity and its expression is dependent on kidney cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf0720b4e561045bb2fb77634b9f3b3d
https://doi.org/10.1101/2022.05.11.491473
https://doi.org/10.1101/2022.05.11.491473
Autor:
Adam J. Funk, Isaac T. Schiefer, F. S. Hall, Ethel Tackie-Yarboi, James Reigle, Robert E. McCullumsmith, Austin Horton, Tue Q T Chau, Alexander Wisner, Frederick E. Williams
Publikováno v:
ACS Chem Neurosci
Photoaffinity labeling (PAL) remains one of the most widely utilized methods of determining protein targets of drugs. Although useful, the scope of this technique has been limited to in vitro applications because of the inability of UV light to penet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cfc79da07b8539f9f58456ceb17f94
https://doi.org/10.1021/acschemneuro.0c00416
https://doi.org/10.1021/acschemneuro.0c00416
Autor:
Rammohan Shukla, Rawan Alnafisah, Scott A. Miruzzi, Justin F. Creeden, Abdul-Rizaq Hamoud, Khaled Alganem, Jaroslaw Meller, Robert E. McCullumsmith, James Reigle, Nicholas D. Henkel, Hunter M. Eby, Ali S Imami
Publikováno v:
Neuropsychopharmacology
CNS disorders, and in particular psychiatric illnesses, lack definitive disease-altering therapeutics. The limited understanding of the mechanisms driving these illnesses with the slow pace and high cost of drug development exacerbates this issue. Fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e0f8844518f322c04bf6529ba14e16
https://doi.org/10.1038/s41386-020-0752-6
https://doi.org/10.1038/s41386-020-0752-6
Autor:
Adam J. Funk, Rammohan Shukla, Jaroslaw Meller, Robert E. McCullumsmith, Rawan Alnafisah, Sinead M. O’Donovan, James Reigle
Schizophrenia (SCZ) is a severe and debilitating mental illness. Antipsychotic drugs (APDs) are used to treat both positive and negative SCZ symptoms, by influencing the cellular, subcellular-synaptic, and molecular processes. We posit that these eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f961fc85f6cfe33ae17d1e3d064c469d
https://doi.org/10.1101/2021.10.26.465949
https://doi.org/10.1101/2021.10.26.465949
Autor:
Xiaojun Wu, James Reigle, Erica A K DePasquale, James H. Meador-Woodruff, Vahram Haroutunian, Rammohan Shukla, Emily Devine, Margaret Hahn, Micah Simmons, Christy Au-Yeung, Khaled Alganem, Jarek Meller, Chang-Gyu Hahn, Xiaolu Zhang, Hunter M. Eby, Roshanak Asgariroozbehani, Robert E. McCullumsmith
Publikováno v:
Molecular psychiatry. 26(12)
While the pathophysiology of schizophrenia has been extensively investigated using homogenized postmortem brain samples, few studies have examined changes in brain samples with techniques that may attribute perturbations to specific cell types. To fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac833ff095fae4b1578dd65e7ecd839
https://pubmed.ncbi.nlm.nih.gov/34272489
https://pubmed.ncbi.nlm.nih.gov/34272489
Autor:
W. Marston Linehan, Megan E Bischoff, Yuanwei Zang, Hai Bui, Nicholas J Talbot, David R. Plas, Charuhas V. Thakar, Krishnanath Gaitonde, Julio A. Landero Figueroa, Qing Zhang, Dina Secic, John T. Cunningham, Laura S. Schmidt, Xiang Zhang, James Reigle, Collin Wetzel, Jacek Biesiada, Abhinav Sidana, Behrouz Shamsaei, Yongzhen Zhang, Johnson Chu, Maria F. Czyzyk-Krzeska, Mario Medvedovic, Jarek Meller
Publikováno v:
J Clin Invest
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the most common histologically defined renal cancer. However, it is not a uniform disease and includes several genetic subtypes with different prognoses. ccRCC is also characterized by distinctiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48df11701fae00c2bd6e0007037e9ed9
https://europepmc.org/articles/PMC7773408/
https://europepmc.org/articles/PMC7773408/