Zobrazeno 1 - 10
of 48
pro vyhledávání: '"James R. Van Brocklyn"'
Autor:
Nicholas Young, James R. Van Brocklyn
Publikováno v:
The Scientific World Journal, Vol 6, Pp 946-966 (2006)
Sphingosine-1-phosphate (S1P) is a bioactive lipid capable of eliciting dramatic effects in a variety of cell types. Signaling by this molecule is by a family of five G protein—coupled receptors named S1P1–5 that signal through a variety of pathw
Externí odkaz:
https://doaj.org/article/1455a63e179d4964ac4b89541a787da9
Autor:
Norman L. Lehman, Balveen Kaur, Jeffery A. Ecsedy, David A. Kellough, Walter H. Meisen, Jeffrey Wojton, James R. Van Brocklyn
Morphologic changes of GB neurosphere cells treated with different Aurora-A inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffb119fe5115a9e74f8b3957070cc69
https://doi.org/10.1158/0008-5472.22403394
https://doi.org/10.1158/0008-5472.22403394
Autor:
Norman L. Lehman, Balveen Kaur, Jeffery A. Ecsedy, David A. Kellough, Walter H. Meisen, Jeffrey Wojton, James R. Van Brocklyn
Legend for Supplemental Figures S1-S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7278f5a6ab2f1f54665677e493d8323c
https://doi.org/10.1158/0008-5472.22403400
https://doi.org/10.1158/0008-5472.22403400
Publikováno v:
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 163:26-36
Sphingolipids are components of all eukaryotic cells that play important roles in a wide variety of biological processes. Ceramides and sphingosine-1-phosphate (S1P) are signaling molecules that regulate cell fate decisions in a wide array of species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec953e1d337b9eed742b151917dfbcb
https://doi.org/10.1016/j.cbpb.2012.05.006
https://doi.org/10.1016/j.cbpb.2012.05.006
Publikováno v:
Neuro-Oncology. 14:405-415
FTY720 is a sphingosine analogue that down regulates expression of sphingosine-1-phosphate receptors and causes apoptosis of multiple tumor cell types, including glioma cells. This study examined the effect of FTY720 on brain tumor stem cells (BTSCs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9175d332a9c4b92be9539fe68e24275d
https://doi.org/10.1093/neuonc/nos005
https://doi.org/10.1093/neuonc/nos005
Autor:
Robert Bittman, Gabor Tigyi, William J. Valentine, Jianxiong Liu, Daniel A. Osborne, Yuko Fujiwara, Virginia I. Godwin, Abby L. Parrill, James R. Van Brocklyn
Publikováno v:
Journal of Biological Chemistry. 286:30513-30525
FTY720 phosphate (FTY720P) is a high potency agonist for all the endothelial differentiation gene family sphingosine 1-phosphate (S1P) receptors except S1P receptor subtype 2 (S1P(2)). To map the distinguishing features of S1P(2) ligand recognition,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4141617b90967d45056a8a90993c71
https://doi.org/10.1074/jbc.m111.263442
https://doi.org/10.1074/jbc.m111.263442
MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells
Autor:
Gerard J. Nuovo, Jakub Godlewski, Michał Nowicki, E. Antonio Chiocca, James R. Van Brocklyn, Michael De Lay, Jeff Palatini, Sean E. Lawler, Agnieszka Bronisz, Michael C. Ostrowski
Publikováno v:
Molecular Cell. 37:620-632
To sustain tumor growth, cancer cells must be able to adapt to fluctuations in energy availability. We have identified a single microRNA that controls glioma cell proliferation, migration, and responsiveness to glucose deprivation. Abundant glucose a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829196bc9d1340ae1fa7a668b53545b4
https://doi.org/10.1016/j.molcel.2010.02.018
https://doi.org/10.1016/j.molcel.2010.02.018
Autor:
Mei-Chuan Huang, Katherine Gundling, Jia-Jun Liao, Mahesh Yadav, Edward J. Goetzl, Matthias Wabl, James R. Van Brocklyn, Katharine Fast
Publikováno v:
The FASEB Journal
Anti-lymphocyte antibodies (Abs) that suppress T-cell chemotactic and other responses to sphingosine 1-phosphate (S1P), but not to chemokines, were found in a lymphopenic patient with recurrent infections. Lymphocyte type 1 S1P receptor (S1P1) that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932a7a7826d2474321e96d25d6461453
Autor:
James R. Van Brocklyn
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 7:984-990
Glioblastoma multiforme (GBM) is a highly malignant brain tumor. The interconvertible bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide have profound effects on GBM cells, with ceramide causing cell death and S1P leading to cell surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b656eb63c249eae3b6f591105ee92076
https://doi.org/10.2174/138955707782110123
https://doi.org/10.2174/138955707782110123
Publikováno v:
Experimental Cell Research. 313:1615-1627
Sphingosine-1-phosphate (S1P) is a bioactive lipid that signals through a family of five G-protein-coupled receptors, termed S1P(1-5). S1P stimulates growth and invasiveness of glioma cells, and high expression levels of the enzyme that forms S1P, sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9052c4a98982b5ef7d2bf5eff3370de0
https://doi.org/10.1016/j.yexcr.2007.02.009
https://doi.org/10.1016/j.yexcr.2007.02.009