Zobrazeno 1 - 9
of 9
pro vyhledávání: '"James R. Valcourt"'
Autor:
James R. Valcourt, Sharmistha Kundu, Robert E. Kingston, Divya Venkatasubramanian, Roya Huang, Sharad Ramanathan
Publikováno v:
Cell reports
SUMMARY As pluripotent human embryonic stem cells progress toward one germ layer fate, they lose the ability to adopt alternative fates. Using a low-dimensional reaction coordinate to monitor progression toward ectoderm, we show that a differentiatin
Autor:
Divya Venkatasubramanian, Sharmistha Kundu, Robert E. Kingston, Roya Huang, Sharad Ramanathan, James R. Valcourt
Publikováno v:
SSRN Electronic Journal.
As pluripotent human embryonic stem cells progress towards one germ layer fate, they lose the ability to adopt alternative fates. It is unknown how the cells’ competence for these alternative fates changes along their developmental trajectory or if
Autor:
Robert E. Kingston, James R. Valcourt, Sharmistha Kundu, Roya Huang, Sharad Ramanathan, Divya Venkatasubramanian
As pluripotent human embryonic stem cells progress towards one germ layer fate, they lose the ability to adopt alternative fates. It is unknown how the cells’ competence for these alternative fates changes along their developmental trajectory or if
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae95f2d39cae62d56b783533d66fcc1d
https://doi.org/10.1101/867010
https://doi.org/10.1101/867010
Autor:
Hyunil Jo, William F. DeGrado, Yoga Srinivasan, David E. Shaw, Ron O. Dror, Shaun R. Coughlin, Michael Grabe, James R. Valcourt, Albert C. Pan, Michael P. Bokoch, Sara Capponi
Publikováno v:
Biochemistry, vol 57, iss 39
The pathways that G protein-coupled receptor (GPCR) ligands follow as they bind to or dissociate from their receptors are largely unknown. Protease-activated receptor-1 (PAR1) is a GPCR activated by intramolecular binding of a tethered agonist peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cc10f18aa91a77f699cf29f1b515a0
https://europepmc.org/articles/PMC6584023/
https://europepmc.org/articles/PMC6584023/
Autor:
James R. Valcourt, Jackie Johnson
A brilliant young scientist introduces us to the fascinating field that is changing our understanding of how the body works and the way we can approach healing.SYSTEMATIC is the first book to introduce general readers to systems biology, which is imp
Autor:
Albert C. Pan, Celine Valant, Arthur Christopoulos, James R. Valcourt, Hillary F. Green, Raphaël Rahmani, Patrick M. Sexton, David E. Shaw, Jonathan B. Baell, Daniel H. Arlow, Meritxell Canals, Ron O. Dror, David W. Borhani, J. Robert Lane
Publikováno v:
Nature. 503:295-299
Binding modes and molecular mechanisms of several allosteric modulators of a prototypical G-protein-coupled receptor are revealed using atomic-level simulations and validated by the rational design of a modulator with substantially altered effects. A
Autor:
Michael P. Bokoch, Hyunil I. Jo, James R. Valcourt, Yoga Srinivasan, Kazuma Yasuhara, Albert C. Pan, Ron O. Dror, David E. Shaw, William F. DeGrado, Shaun R. Coughlin
Publikováno v:
Biophysical Journal. 108(2)
Autor:
Hilary A. Coller, Mina L Kojima, Olukunle O. Demuren, James R. Valcourt, Erin M. Haley, Johanna M.S. Lemons
Publikováno v:
Cell cycle (Georgetown, Tex.). 11(9)
Quiescence is a state of reversible cell cycle arrest that can grant protection against many environmental insults. In some systems, cellular quiescence is associated with a low metabolic state characterized by a decrease in glucose uptake and glycol
Autor:
Patrick M. Sexton, Albert C. Pan, Hillary F. Green, J. Robert Lane, Daniel H. Arlow, David E. Shaw, David W. Borhani, Celine Valant, Meritxell Canals, Raphaël Rahmani, Arthur Christopoulos, James R. Valcourt, Jonathan B. Baell, Ron O. Dror
Publikováno v:
Biophysical Journal. 106:100a
The design of G protein-coupled receptor (GPCR) allosteric modulators, an active area of modern pharmaceutical research, has proven challenging because neither the binding modes nor the molecular mechanisms of such drugs are known. Here we determined