Zobrazeno 1 - 10
of 205
pro vyhledávání: '"James R. Trudell"'
Autor:
Kelle M. Franklin, Liana eAsatryan, Michael W. Jakowec, James R. Trudell, Richard Lowell Bell, Daryl L. Davies
Publikováno v:
Frontiers in Neuroscience, Vol 8 (2014)
Alcohol use disorders (AUDs) have a staggering socioeconomic impact. Few therapeutic options are available, and they are largely inadequate. These shortcomings highlight the urgent need to develop effective medications to prevent and/or treat AUDs. A
Externí odkaz:
https://doaj.org/article/6cd83787e839449589d903bdb3020c2f
Autor:
Cecilia M, Borghese, Hua-Yu L, Wang, Stanton F, McHardy, Robert O, Messing, James R, Trudell, R Adron, Harris, Edward J, Bertaccini
Publikováno v:
Proc Natl Acad Sci U S A
Tethered photoswitches are molecules with two photo-dependent isomeric forms, each with different actions on their biological targets. They include reactive chemical groups capable of covalently binding to their target. Our aim was to develop a β-su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::156dd789b5aca4d1c49335969fdd5549
https://pubmed.ncbi.nlm.nih.gov/33593898
https://pubmed.ncbi.nlm.nih.gov/33593898
Autor:
Hua-Yu L. Wang, Robert O. Messing, Cecilia M. Borghese, R. Adron Harris, Stanton F. McHardy, James R. Trudell, Edward J. Bertaccini
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Tethered photoswitches are molecules with two photo-dependent isomeric forms, each with different actions on their biological targets. They include reactive chemical groups capable of covalently binding to their target. Our aim was to develop a β-su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d338731e53699bfd17304e25ae3ee79a
https://doi.org/10.1073/pnas.2008178118
https://doi.org/10.1073/pnas.2008178118
Autor:
James R. Trudell, Maya Popova, Sylvia Nguyen, Liana Asatryan, Larry Rodriguez, Michael Bloomfield, Daryl L. Davies
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2471, p 2471 (2020)
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2471, p 2471 (2020)
Mouse models of alcohol use disorder (AUD) revealed purinergic P2X4 receptors (P2X4Rs) as a promising target for AUD drug development. We have previously demonstrated that residues at the transmembrane (TM)&ndash
ectodomain interface and within
ectodomain interface and within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be05afe6ca030981d8f245dca60ae44
Autor:
Natasha C. Pflanz, S. John Mihic, Anna W. Daszkowski, James R. Trudell, Garrett L. Cornelison
Benzodiazepines are positive allosteric modulators of the GABA(A) receptor (GABA(A)R), acting at the α–γ subunit interface to enhance GABA(A)R function. GABA or benzodiazepine binding induces distinct conformational changes in the GABA(A)R. The m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcbc8a7f70bfa6c02c44bb320f65676
https://europepmc.org/articles/PMC5971448/
https://europepmc.org/articles/PMC5971448/
Autor:
Edward J. Bertaccini, Madeline A. Cullins, James R. Trudell, Ui S. Lee, R. Adron Harris, Carlos I. Ruiz, Cecilia M. Borghese
Publikováno v:
ACS Chemical Neuroscience. 7:100-108
Alcohols inhibit γ-aminobutyric acid type A ρ1 receptor function. After introducing mutations in several positions of the second transmembrane helix in ρ1, we studied the effects of ethanol and hexanol on GABA responses using two-electrode voltage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fea37dd590d34a86feeac7b1e6b856
https://doi.org/10.1021/acschemneuro.5b00246
https://doi.org/10.1021/acschemneuro.5b00246
Publikováno v:
ACS Chemical Neuroscience
Anesthetics are thought to mediate a portion of their activity via binding to and modulation of potassium channels. In particular, tandem pore potassium channels (K2P) are transmembrane ion channels whose current is modulated by the presence of gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a35806f01d3d14d8030b967379f5ed3
http://europepmc.org/articles/PMC4306477
http://europepmc.org/articles/PMC4306477
Autor:
Karan H. Muchhala, Daya I. Perkins, Anna Naito, Gregg E. Homanics, James R. Trudell, Daryl L. Davies, Liana Asatryan, Ronald L. Alkana
Publikováno v:
Molecular Pharmacology. 86:635-646
A critical obstacle to developing effective medications to prevent and/or treat alcohol use disorders is the lack of specific knowledge regarding the plethora of molecular targets and mechanisms underlying alcohol (ethanol) action in the brain. To id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64708cde449337a76f974a87293f9d32
https://doi.org/10.1124/mol.114.093773
https://doi.org/10.1124/mol.114.093773
Autor:
James R. Trudell, Ronald L. Alkana, Sheraz Khoja, Megan M. Yardley, Nhat Hyunh, Nicos A. Petasis, Stan G. Louie, Liana Asatryan, Daryl L. Davies
Publikováno v:
The International Journal of Neuropsychopharmacology. 17:907-916
Our laboratory is investigating ivermectin (IVM) and other members of the avermectin family as new pharmaco-therapeutics to prevent and/or treat alcohol use disorders (AUDs). Prior work found that IVM significantly reduced ethanol intake in mice and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57276ae1677ab5dffacfd97cb1d9940c
https://doi.org/10.1017/s1461145713001703
https://doi.org/10.1017/s1461145713001703
Publikováno v:
Journal of Neurochemistry. 128:363-375
Alcohols and inhaled anesthetics modulate GABA(A) receptor (GABA(A)R) function via putative binding sites within the transmembrane regions. The relative position of the amino acids lining these sites could be either inter- or intra-subunit. We introd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c9c5e0a610cbfee65a66401abe9946
https://doi.org/10.1111/jnc.12476
https://doi.org/10.1111/jnc.12476