Zobrazeno 1 - 10
of 206
pro vyhledávání: '"James R. Trudell"'
Autor:
Maya Popova, Larry Rodriguez, James R. Trudell, Sylvia Nguyen, Michael Bloomfield, Daryl L. Davies, Liana Asatryan
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2471 (2020)
Mouse models of alcohol use disorder (AUD) revealed purinergic P2X4 receptors (P2X4Rs) as a promising target for AUD drug development. We have previously demonstrated that residues at the transmembrane (TM)–ectodomain interface and within the TM1 s
Externí odkaz:
https://doaj.org/article/44c1e0fddd7a4697bf9c5e35e6209c15
Autor:
Kelle M. Franklin, Liana eAsatryan, Michael W. Jakowec, James R. Trudell, Richard Lowell Bell, Daryl L. Davies
Publikováno v:
Frontiers in Neuroscience, Vol 8 (2014)
Alcohol use disorders (AUDs) have a staggering socioeconomic impact. Few therapeutic options are available, and they are largely inadequate. These shortcomings highlight the urgent need to develop effective medications to prevent and/or treat AUDs. A
Externí odkaz:
https://doaj.org/article/6cd83787e839449589d903bdb3020c2f
Autor:
Cecilia M, Borghese, Hua-Yu L, Wang, Stanton F, McHardy, Robert O, Messing, James R, Trudell, R Adron, Harris, Edward J, Bertaccini
Publikováno v:
Proc Natl Acad Sci U S A
Tethered photoswitches are molecules with two photo-dependent isomeric forms, each with different actions on their biological targets. They include reactive chemical groups capable of covalently binding to their target. Our aim was to develop a β-su
Autor:
Hua-Yu L. Wang, Robert O. Messing, Cecilia M. Borghese, R. Adron Harris, Stanton F. McHardy, James R. Trudell, Edward J. Bertaccini
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Tethered photoswitches are molecules with two photo-dependent isomeric forms, each with different actions on their biological targets. They include reactive chemical groups capable of covalently binding to their target. Our aim was to develop a β-su
Autor:
James R. Trudell, Maya Popova, Sylvia Nguyen, Liana Asatryan, Larry Rodriguez, Michael Bloomfield, Daryl L. Davies
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2471, p 2471 (2020)
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2471, p 2471 (2020)
Mouse models of alcohol use disorder (AUD) revealed purinergic P2X4 receptors (P2X4Rs) as a promising target for AUD drug development. We have previously demonstrated that residues at the transmembrane (TM)&ndash
ectodomain interface and within
ectodomain interface and within
Autor:
Samuel Murail, Rebecca J Howard, Torben Broemstrup, Edward J Bertaccini, R Adron Harris, James R Trudell, Erik Lindahl
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 10, p e1002710 (2012)
Cys-loop receptors constitute a superfamily of pentameric ligand-gated ion channels (pLGICs), including receptors for acetylcholine, serotonin, glycine and γ-aminobutyric acid. Several bacterial homologues have been identified that are excellent mod
Externí odkaz:
https://doaj.org/article/d08ef181a855484ab0859f2c6b752cde
Autor:
Edward J. Bertaccini, Madeline A. Cullins, James R. Trudell, Ui S. Lee, R. Adron Harris, Carlos I. Ruiz, Cecilia M. Borghese
Publikováno v:
ACS Chemical Neuroscience. 7:100-108
Alcohols inhibit γ-aminobutyric acid type A ρ1 receptor function. After introducing mutations in several positions of the second transmembrane helix in ρ1, we studied the effects of ethanol and hexanol on GABA responses using two-electrode voltage
Autor:
Natasha C. Pflanz, S. John Mihic, Anna W. Daszkowski, James R. Trudell, Garrett L. Cornelison
Benzodiazepines are positive allosteric modulators of the GABA(A) receptor (GABA(A)R), acting at the α–γ subunit interface to enhance GABA(A)R function. GABA or benzodiazepine binding induces distinct conformational changes in the GABA(A)R. The m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcbc8a7f70bfa6c02c44bb320f65676
https://europepmc.org/articles/PMC5971448/
https://europepmc.org/articles/PMC5971448/
Publikováno v:
ACS Chemical Neuroscience
Anesthetics are thought to mediate a portion of their activity via binding to and modulation of potassium channels. In particular, tandem pore potassium channels (K2P) are transmembrane ion channels whose current is modulated by the presence of gener
Autor:
Karan H. Muchhala, Daya I. Perkins, Anna Naito, Gregg E. Homanics, James R. Trudell, Daryl L. Davies, Liana Asatryan, Ronald L. Alkana
Publikováno v:
Molecular Pharmacology. 86:635-646
A critical obstacle to developing effective medications to prevent and/or treat alcohol use disorders is the lack of specific knowledge regarding the plethora of molecular targets and mechanisms underlying alcohol (ethanol) action in the brain. To id