Zobrazeno 1 - 10
of 87
pro vyhledávání: '"James R. Smiley"'
Autor:
Adil Mohamed, Prathyusha Konda, Heather E Eaton, Shashi Gujar, James R Smiley, Maya Shmulevitz
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008803 (2020)
The Dearing isolate of Mammalian orthoreovirus (T3D) is a prominent model of virus-host relationships and a candidate oncolytic virotherapy. Closely related laboratory strains of T3D, originating from the same ancestral T3D isolate, were recently fou
Externí odkaz:
https://doaj.org/article/3a7b10fcfd1c4abc9371650092406963
Autor:
James R. Smiley, Adil Mohamed, Patrick W. K. Lee, Derek R. Clements, Maya Shmulevitz, Shashi Gujar
Publikováno v:
Journal of Virology. 94
Little is known about how genetic variations in viruses affect their success as therapeutic agents. The type 3 Dearing strain of Mammalian orthoreovirus (T3D) is undergoing clinical trials as an oncolytic virotherapy. Worldwide, studies on reovirus o
Publikováno v:
J Virol
Reovirus serotype 3 Dearing (T3D) replicates preferentially in transformed cells and is in clinical trials as a cancer therapy. Laboratory strains of T3D, however, exhibit differences in plaque size on cancer cells and differences in oncolytic activi
Autor:
Adil, Mohamed, Derek R, Clements, Shashi A, Gujar, Patrick W, Lee, James R, Smiley, Maya, Shmulevitz
Publikováno v:
J Virol
Little is known about how genetic variations in viruses affect their success as therapeutic agents. The type 3 Dearing strain of Mammalian orthoreovirus (T3D) is undergoing clinical trials as an oncolytic virotherapy. Worldwide, studies on reovirus o
Publikováno v:
Virology. 511:66-73
Previous studies have shown that HSV-1 infection of lymphocytes induces the tyrosine phosphorylation of several proteins that might correspond to viral or host proteins. VP11/12, a viral tegument protein, is the major HSV-induced tyrosine phosphoryla
Publikováno v:
PLoS Pathogens, Vol 4, Iss 2, p e1000007 (2008)
Treatment of human cells with Type 1 interferons restricts HIV replication. Here we report that the tripartite motif protein TRIM22 is a key mediator. We used transcriptional profiling to identify cellular genes that were induced by interferon treatm
Externí odkaz:
https://doaj.org/article/f3b3335734414ad680f757a4f2b52cf0
Publikováno v:
Virology. 498:31-35
The abundant HSV-1 tegument protein VP11/12 encoded by gene UL46 is essential for induction of the PI3K/Akt-signaling pathway during infection. VP11/12 utilizes tyrosine-based motifs within its C-terminal region to bind the SH2 domains of Src family
The herpes simplex virus 1 (HSV-1) virion host shutoff protein (vhs) degrades viral and cellular mRNAs. Here, we demonstrate for the first time that vhs also boosts translation of viral true late mRNAs in a cell type-dependent manner and that this ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ad209bd79e2acdddf33aaabe9db3e4
https://europepmc.org/articles/PMC6694810/
https://europepmc.org/articles/PMC6694810/
Autor:
Adil Mohamed, Patrick W. K. Lee, Derek R. Clements, Maya Shmulevitz, Shashi Gujar, Prathyusha Konda, James R. Smiley
The Dearing strain of Mammalian orthoreovirus (T3D) is undergoing clinical trials as an oncolytic virotherapeutic agent. In this study, a comprehensive phenotypic and genetic comparison of T3D virus stocks from various laboratories and commercial sou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36671d3e920dc2724590041396040ed4
Autor:
Prathyusha Konda, James R. Smiley, Shashi Gujar, Maya Shmulevitz, Heather E. Eaton, Adil Mohamed
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008803 (2020)
The Dearing isolate of Mammalian orthoreovirus (T3D) is a prominent model of virus-host relationships and a candidate oncolytic virotherapy. Closely related laboratory strains of T3D, originating from the same ancestral T3D isolate, were recently fou