Zobrazeno 1 - 10
of 79
pro vyhledávání: '"James R. Roede"'
Autor:
Ashwini Sri Hari, Rajeswari Banerji, Li-Ping Liang, Ruth E. Fulton, Christopher Quoc Huynh, Timothy Fabisiak, Pallavi Bhuyan McElroy, James R. Roede, Manisha Patel
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102895- (2023)
Glutathione (GSH) depletion, and impaired redox homeostasis have been observed in experimental animal models and patients with epilepsy. Pleiotropic strategies that elevate GSH levels via transcriptional regulation have been shown to significantly de
Externí odkaz:
https://doaj.org/article/ed4713f353534d5c94fce6e8d5efe468
Autor:
Peter S. Harris, Courtney D. McGinnis, Cole R. Michel, John O. Marentette, Richard Reisdorph, James R. Roede, Kristofer S. Fritz
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102792- (2023)
In the U.S., alcohol-associated liver disease (ALD) impacts millions of people and is a major healthcare burden. While the pathology of ALD is unmistakable, the molecular mechanisms underlying ethanol hepatotoxicity are not fully understood. Hepatic
Externí odkaz:
https://doaj.org/article/450bbd80f87647e9beada0434ab3076c
Autor:
Hanan Elajaili, Laura Hernandez-Lagunas, Peter Harris, Genevieve C. Sparagna, Raleigh Jonscher, Denis Ohlstrom, Carmen C. Sucharov, Russell P. Bowler, Hagir Suliman, Kristofer S. Fritz, James R. Roede, Eva S. Nozik
Publikováno v:
Advances in Redox Research, Vol 5, Iss , Pp 100035- (2022)
Extracellular superoxide dismutase (EC-SOD) is highly expressed in the lung and vasculature. A common human single nucleotide polymorphism (SNP) in the matrix binding region of EC-SOD leads to a single amino acid substitution, R213G, and alters EC-SO
Externí odkaz:
https://doaj.org/article/fc2a3c7195df440d8b06a2fc25d73062
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 3, Pp 563-572 (2020)
Simvastatin, a commonly used cholesterol‐lowering drug, inhibits the mevalonate pathway involved in the synthesis of the mitochondrial electron carrier coenzyme Q10 (CoQ10), as well as other bioenergetics substrates. The purpose of this study was t
Externí odkaz:
https://doaj.org/article/b7c09a0748534e4494793d411e38f7c3
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 520-528 (2020)
Statins have a primary indication for the reduction and management of hypercholesterolemia; however, evidence shows that statins have the ability to increase the toxicity of chemotherapeutics within cancer cells by inducing anti-proliferative, anti-m
Externí odkaz:
https://doaj.org/article/9cd9ae23887343ce905a0f4beb874176
Publikováno v:
Advances in Redox Research, Vol 2, Iss , Pp 100008- (2021)
The dithiocarbamate fungicide maneb (MB) has garnered increasing concern due to its association with Parkinson's disease (PD) and the overall negative human health effects of pesticides in agriculture. As one of several environmental toxicant models
Externí odkaz:
https://doaj.org/article/5ea9284889b8463b93a480a88f430ee7
Publikováno v:
BioData Mining, Vol 12, Iss 1, Pp 1-24 (2019)
Abstract Background Analytic methods are available to acquire extensive metabolic information in a cost-effective manner for personalized medicine, yet disease risk and diagnosis mostly rely upon individual biomarkers based on statistical principles
Externí odkaz:
https://doaj.org/article/bab648f5317f4401ade5662e9fc5ef77
Autor:
Rachael Bok, Damian D. Guerra, Ramón A. Lorca, Sara A. Wennersten, Peter S. Harris, Abhishek K. Rauniyar, Sally P. Stabler, Kenneth N. MacLean, James R. Roede, Laura D. Brown, K. Joseph Hurt
Publikováno v:
Redox Biology, Vol 40, Iss , Pp 101827- (2021)
During pregnancy, estrogen (E2) stimulates uterine artery blood flow (UBF) by enhancing nitric oxide (NO)-dependent vasodilation. Cystathionine γ-lyase (CSE) promotes vascular NO signaling by producing hydrogen sulfide (H2S) and by maintaining the r
Externí odkaz:
https://doaj.org/article/4ba24169c8a14e86b9c9066e884fb457
Publikováno v:
Toxicology Reports, Vol 1, Iss C, Pp 435-444 (2014)
A combination of the herbicide paraquat (PQ) and fungicide maneb (MB) has been linked to Parkinson's disease. Previous studies show that this involves an additive toxicity with at least two different mechanisms. However, detailed understanding of mix
Externí odkaz:
https://doaj.org/article/a2dabcb3bd044c60955b6dc3a233f18c
Autor:
James R. Roede, Dean P. Jones
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 651-655 (2014)
Maneb (MB) is a manganese-containing ethylene bis-dithiocarbamate fungicide that is implicated as an environmental risk factor for Parkinson's disease, especially in combination with paraquat (PQ). Dithiocarbamates inhibit aldehyde dehydrogenases, bu
Externí odkaz:
https://doaj.org/article/850c63645dbb48ecaa3fb17ecfee85d1