Zobrazeno 1 - 10
of 11
pro vyhledávání: '"James R. R. Whittle"'
Autor:
Celia Santos, Peter D. Kwong, Wing-Pui Kong, Baoshan Zhang, Yi Zhang, Amy Ransier, Robert T. Bailer, Kwanyee Leung, Richard A. Koup, Sam Darko, Tatsiana Bylund, Sandeep N. Narpala, Hadi M. Yassine, Ulrich Baxa, Cinque Soto, Rebecca A. Gillespie, M. Gordon Joyce, Julie E. Ledgerwood, Xueling Wu, Lawrence Shapiro, Madhu Prabhakaran, Adam K. Wheatley, Ivelin S. Georgiev, Kanta Subbarao, Chen-Hsiang Shen, Adrian B. McDermott, Gwo-Yu Chuang, Yumiko Matsuoka, Mangaiarkarasi Asokan, James C. Mullikin, Yaroslav Tsybovsky, Lingshu Wang, Paul V. Thomas, Jeffrey C. Boyington, Aliaksandr Druz, James R R Whittle, Daniel C. Douek, Eun Sung Yang, Mario Roederer, Masaru Kanekiyo, John R. Mascola, Barney S. Graham, Christopher R. Lees
Publikováno v:
Cell. 166:609-623
Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1670149e5d83cb99d0d404a3c541e88d
https://doi.org/10.1016/j.cell.2016.06.043
https://doi.org/10.1016/j.cell.2016.06.043
Autor:
John R. Mascola, Srinivas S. Rao, Takuya Yamamoto, Ulrich Baxa, Barney S. Graham, John Paul Todd, Jeffrey I. Cohen, Richard A. Koup, Michael G. Rossmann, Adrian B. McDermott, Gary J. Nabel, Geng Meng, M. Gordon Joyce, Wei Bu, Masaru Kanekiyo, James R R Whittle, Sandeep Narpala
Publikováno v:
Cell
SummaryEpstein-Barr virus (EBV) represents a major global health problem. Though it is associated with infectious mononucleosis and ∼200,000 cancers annually worldwide, a vaccine is not available. The major target of immunity is EBV glycoprotein 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b32ca403dd287874389fe9761bd3d5c
Autor:
Jeffrey C. Boyington, Chih Jen Wei, Masaru Kanekiyo, Lingshu Wang, Wing Pui Kong, Patrick M. McTamney, James R R Whittle, Hadi M. Yassine, Srinivas S. Rao, Gary J. Nabel
Publikováno v:
Nature
Influenza viruses pose a significant threat to the public and are a burden on global health systems. Each year, influenza vaccines must be rapidly produced to match circulating viruses, a process constrained by dated technology and vulnerable to unex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da0584321c7ffe24c1b026fd818d5aa
https://doi.org/10.1038/nature12202
https://doi.org/10.1038/nature12202
Autor:
James R. R. Whittle, Ruijun Zhang, Surender Khurana, Lisa R. King, Jody Manischewitz, Hana Golding, Philip R. Dormitzer, Barton F. Haynes, Emmanuel B. Walter, M. Anthony Moody, Thomas B. Kepler, Hua-Xin Liao, Stephen C. Harrison
Publikováno v:
Proceedings of the National Academy of Sciences. 108:14216-14221
Seasonal antigenic drift of circulating influenza virus leads to a requirement for frequent changes in vaccine composition, because exposure or vaccination elicits human antibodies with limited cross-neutralization of drifted strains. We describe a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3967674a00d91bce98d8e03e779203
https://doi.org/10.1073/pnas.1111497108
https://doi.org/10.1073/pnas.1111497108
Autor:
James R R Whittle, Gregory E. Crawford, Francis S. Collins, Denise Tai, David Ginsburg, Mark J. Daly, Shujun Luo, Yi Chen, Daixing Zhou, Sean Davis, Bryn D. Webb, Elliott H. Margulies, Thomas J. Vasicek, John A. Bernat, Tyra G. Wolfsberg, Ingeborg Holt
Publikováno v:
Genome Research. 16:123-131
A major goal in genomics is to understand how genes are regulated in different tissues, stages of development, diseases, and species. Mapping DNase I hypersensitive (HS) sites within nuclear chromatin is a powerful and well-established method of iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b2a78040bc9c165edd844950c9aa04
https://doi.org/10.1101/gr.4074106
https://doi.org/10.1101/gr.4074106
Autor:
Jonathan H. Dennis, Michael Brudno, Anindya Dutta, Richard M. Myers, Ian Dunham, Eduardo Eyras, S. S. Marticke, Alexandre Reymond, Anason S. Halees, Greg Schuler, M. G. Rosenfeld, Mikhail Nefedov, Robert E. Kingston, Elizabeth Anton, Tyra G. Wolfsberg, Alice C. Young, Kris A. Wetterstrand, C. K. Glass, Nancy F. Hansen, Gayle K. Clelland, Diane I. Schroeder, Jean L. Chang, H. Shin, Zhou Zhu, Nigel P. Carter, William Stafford Noble, Jenny McDowell, Ugrappa Nagalakshmi, Heike Fiegler, Philipp Kapranov, Peggy J. Farnham, Joanna C. Fowler, S. C. Harvey, Michael O. Dorschner, D. R. Inman, George V. Popescu, Jan-Jaap Wesselink, P. Groth, Baoli Zhu, H. Hirsch, James C. Wallace, Elise A. Feingold, S. Jin, Gabriel Robins, Thomas R. Gingeras, F. Denoeud, W. Tongprasit, Robert Castelo, Ross C. Hardison, John A. Stamatoyannopoulos, Joel Rozowsky, Eric A. Stone, Zheng Lian, J. E. Norton, Y. S. Kwon, Viktor Stolc, Michael C. Pirrung, Min-Feng Yu, A. Yang, W. J. Kent, Peter J. Sabo, Stephen Hartman, Stylianos E. Antonarakis, Tae Hoon Kim, H. Kim, Baishali Maskeri, Thomas Royce, R. Luna, Sherman M. Weissman, Tim Hubbard, Oliver M. Dovey, Ewan Birney, Kate R. Rosenbloom, Robert M. Andrews, Damian Keefe, Arend Sidow, D. Zhou, Jane Grimwood, Ulas Karaoz, Zhiping Weng, H. Burden, Michael C. Zody, Hiram Clawson, Gerry Bouffard, S. van Calcar, Mark Dickson, Kevin Struhl, Ingeborg Holt, Emmanouil T. Dermitzakis, T. J. Vasicek, Peter J. Good, Charles R. Cantor, Hari Tammana, Josée Dostie, Prachi Shah, Elliott H. Margulies, Peter D. Ellis, Mark S. Guyer, Christopher M. Taylor, Patrick A. Navas, Dione Kampa, Colin N. Dewey, Lior Pachter, Christof Koch, George Asimenos, James R R Whittle, Gregory E. Crawford, Jane B. Lian, Pamela J. Thomas, Kazutoyo Osoegawa, Webb Miller, Chunxu Qu, Nele Gheldof, Keith D. James, Sandeep Patel, Todd Richmond, Jacquelyn R. Idol, Michael A. Singer, Tomoko M. Tabuchi, Adam Siepel, Yutao Fu, David Vetrie, Long H. Nguyen, Michael Snyder, William H. Majoros, Michael R. Brent, Nathan D. Trinklein, Leah O. Barrera, Mark Gerstein, Srinka Ghosh, Sara J. Hartman, Jade P. Vinson, C. L. Middle, Sambath Chung, George Stamatoyannopoulos, Y. Nakayama, George M. Church, Job Dekker, Olof Emanuelsson, Julien Lagarde, Roderic Guigó, Marco A. Marra, Jeremy Schmutz, Daryl J. Thomas, Yong Yu, M. R. McCormick, Xiang-Dong Fu, Richard Humbert, Jennifer L. Ashurst, Alexander E. Urban, Sarah Wilcox, Ghia Euskirchen, Michael Kamal, Cordelia Langford, Jacquie Schein, Gregory M. Cooper, Paul Bertone, Eric S. Lander, C. Ding, Antonio Piccolboni, Steven L. Salzberg, Rhonda Harrison, Matthew J. Oberley, E. A. Sekinger, Mihaela Pertea, Bing Ren, H. K. Kim, Roland Green, Shelley Force Aldred, Laura Elnitski, Michael Hawrylycz, Andrew J. Mungall, Kerstin Lindblad-Toh, David B. Jaffe, Andreas D. Baxevanis, L. Liefer, Michele Clamp, David Haussler, Jill Cheng, John L. Rinn, S. Kamholz, Vicki L. Wraight, H. Sethi, Francis S. Collins, Steven J.M. Jones, Serafim Batzoglou, P. J. De Jong, Matthew E. Portnoy, Stefan Bekiranov, M. McArthur, Shu-Jin Luo, Eric D. Green, Robert W. Blakesley, Tarjei S. Mikkelsen, Z. Ye, Pawandeep Dhami, Neerja Karnani
Publikováno v:
Science. 306:636-640
The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements in the human genome sequence. The pilot phase of the Project is focused on a specified 30 megabases (∼1%) of the human genome sequence and is organized as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8541955a585a60527e3acae6baff99
https://doi.org/10.1126/science.1105136
https://doi.org/10.1126/science.1105136
Autor:
Madhu Prabhakaran, Masaru Kanekiyo, Daniel Lingwood, Adam K. Wheatley, Sandeep Narpala, Rodrigo Matus-Nicodemos, James R R Whittle, Barney S. Graham, Gary J. Nabel, Adrian B. McDermott, Hadi M. Yassine, Julie E. Ledgerwood, Richard A. Koup, Robert T. Bailer, Steven S. Ma
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 195(2)
Because of significant viral diversity, vaccines that elicit durable and broad protection against influenza have been elusive. Recent research has focused on the potential of highly conserved regions of the viral hemagglutinin (HA) as targets for bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ae414543d6387cc0e894f512df9780
https://pubmed.ncbi.nlm.nih.gov/26078272
https://pubmed.ncbi.nlm.nih.gov/26078272
Autor:
Arlene H. Sharpe, Krystyna Mozdzanowska, James R R Whittle, Scott E. Hensley, Maura C. Strauman, Amaya I. Wolf, Jan Erikson, Katie L. Williams, Andrew J. Caton, Jeffrey N. Weiser
Publikováno v:
Journal of virology. 88(20)
Pathogen-specific antibodies (Abs) protect against respiratory infection with influenza A virus (IAV) and Streptococcus pneumoniae and are the basis of effective vaccines. Sequential or overlapping coinfections with both pathogens are common, yet the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f8f34b9b3444f18d078b81d637c32e
https://pubmed.ncbi.nlm.nih.gov/25100838
https://pubmed.ncbi.nlm.nih.gov/25100838
Autor:
Jonathan W. Yewdell, Adrian B. McDermott, Adam K. Wheatley, Daniel Lingwood, Richard A. Koup, Masaru Kanekiyo, James R R Whittle, Julie E. Ledgerwood, Steven S. Ma, Chih Jen Wei, Sandeep Narpala, Gary J. Nabel, Barney S. Graham, Gregory M. Frank, Lan Wu, Hadi M. Yassine
Publikováno v:
Journal of virology. 88(8)
An understanding of the antigen-specific B-cell response to the influenza virus hemagglutinin (HA) is critical to the development of universal influenza vaccines, but it has not been possible to examine these cells directly because HA binds to sialic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d463a7d404d45ed2fa9ef7f179792a
https://pubmed.ncbi.nlm.nih.gov/24501410
https://pubmed.ncbi.nlm.nih.gov/24501410
Elicitation of broadly neutralizing influenza antibodies in animals with previous influenza exposure
Autor:
Gary J. Nabel, Chih Jen Wei, Hadi M. Yassine, Patrick M. McTamney, Jason G. D. Gall, James R R Whittle, Jeffrey C. Boyington
Publikováno v:
Science translational medicine. 4(147)
The immune system responds to influenza infection by producing neutralizing antibodies to the viral surface protein, hemagglutinin (HA), which regularly changes its antigenic structure. Antibodies that target the highly conserved stem region of HA ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd45a31f472f3f3cbf00ef1cb7d0b5c
https://pubmed.ncbi.nlm.nih.gov/22896678
https://pubmed.ncbi.nlm.nih.gov/22896678