Zobrazeno 1 - 10
of 11
pro vyhledávání: '"James R. Pancoast"'
Autor:
Ahmed I Mahmoud, Francisco X Galdos, Katherine A Dinan, Mark P Jedrychowski, Jeffrey C Davis, Ana Vujic, Inbal Rachmin, Christian Shigley, James R Pancoast, Samuel Lee, Jennifer Hollister-Lock, Catherine M MacGillivray, Steven P Gygi, Douglas A Melton, Gordon C Weir, Richard T Lee
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204595 (2018)
The in vivo microenvironment of tissues provides myriad unique signals to cells. Thus, following isolation, many cell types change in culture, often preserving some but not all of their in vivo characteristics in culture. At least some of the in vivo
Externí odkaz:
https://doaj.org/article/105ba49f67b348fb8916c00f5caeeb50
Autor:
James R. Pancoast, Jennifer Hollister-Lock, Douglas A. Melton, Ahmed I. Mahmoud, Catherine MacGillivray, Francisco X Galdos, Richard T. Lee, Inbal Rachmin, Mark P. Jedrychowski, Gordon C. Weir, Steven P. Gygi, Samuel C. K. Lee, Ana Vujic, Katherine A Dinan, Jeffrey C. Davis, Christian Shigley
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204595 (2018)
PLoS ONE
PLoS ONE
The in vivo microenvironment of tissues provides myriad unique signals to cells. Thus, following isolation, many cell types change in culture, often preserving some but not all of their in vivo characteristics in culture. At least some of the in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f8a8528f5753c09b5ab65c97cc67d8
Autor:
James R. Pancoast, Yanet Gomez, Colin Marts, Melanie J. Mills, Claudio Macias-Trevino, Kourtney R. Mendello, Hye Lim Noh, Amy J. Wagers, Taekyoon Kim, Jason K. Kim, Francesco S. Loffredo, Ornella Barrandon, Katherine B. LeClair, Tommaso Poggioli, Alexander S. Banks, Richard T. Lee, Shannon H. Carroll, Douglas A. Melton, Sezin Dagdeviren, Ryan G. Walker, David E. Cohen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Insulin resistance is associated with aging in mice and humans. We have previously shown that administration of recombinant GDF11 (rGDF11) to aged mice alters aging phenotypes in the brain, skeletal muscle, and heart. While the closely related protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4557a828d5807c3af1ea9df3f3fdd7e0
https://pubmed.ncbi.nlm.nih.gov/32165710
https://pubmed.ncbi.nlm.nih.gov/32165710
Autor:
Sangwon Byun, Whitney Young, John D. Kisiday, Richard T. Lee, James R. Pancoast, Paul H. Liebesny, Alan J. Grodzinsky, David D. Frisbie, Keri A. Mroszczyk, Han-Hwa Hung
Publikováno v:
Tissue Engineering Part A. 22:917-927
Tissue engineering approaches using growth factor-functionalized acellular scaffolds to support and guide repair driven by endogenous cells are thought to require a careful balance between cell recruitment and growth factor release kinetics. The obje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f53e9e4aff1317f182c3226c0b77ec2
https://doi.org/10.1089/ten.tea.2015.0524
https://doi.org/10.1089/ten.tea.2015.0524
Autor:
Kirsi M Zitting, David A. Morrow, Inbal Rachmin, Charles A. Czeisler, Richard T. Lee, Caitlin C. O'Meara, James R. Pancoast, Elisabeth M Ricci-Blair, Jeanne F. Duffy, Yilin Feng, Michelle L. O'Donoghue, Christopher P. Cannon, Emily M Christensen
Soluble IL-13 receptor-α1, or sIL13rα1, is a soluble protein that binds to interleukin-13 (IL-13) that has been previously described in mice. The function of sIL13rα1 remains unclear, but it has been hypothesized to act as a decoy receptor for IL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9dccf703c40dc647d420b045e7a296
https://europepmc.org/articles/PMC5814599/
https://europepmc.org/articles/PMC5814599/
Autor:
Parth Patwari, Todd Vannelli, Lei Cai, Francesco S. Loffredo, James R. Pancoast, Jesse Z. Dong, Richard T. Lee
Publikováno v:
Arthritis & Rheumatology. 66:1247-1255
Objective Acute articular injuries lead to an increased risk of progressive joint damage and osteoarthritis (OA), and no therapies are currently available to repair or protect the injured joint tissue. Intraarticular delivery of therapeutic proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dda97f6663f539b8a07b641cd735d75
https://doi.org/10.1002/art.38357
https://doi.org/10.1002/art.38357
Autor:
Jill M. Goldstein, Emilia Gonzalez, Miook Cho, Tommaso Poggioli, Aysu Uygur, Amy J. Wagers, Claudio Macias-Trevino, Francesco S. Loffredo, Ryan G. Walker, Rachel M Tandias, Peiguo Yang, Ana Vujic, Richard T. Lee, James R. Pancoast, Yick W. Fong, Thomas B. Thompson
Publikováno v:
Circulation research. 118(1)
Rationale: Growth differentiation factor 11 (GDF11) and GDF8 are members of the transforming growth factor-β superfamily sharing 89% protein sequence homology. We have previously shown that circulating GDF11 levels decrease with age in mice. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7edfa0401f67c7542b1bd11833cbded
https://pubmed.ncbi.nlm.nih.gov/29301851
https://pubmed.ncbi.nlm.nih.gov/29301851
Age-related diastolic dysfunction is a major factor in the epidemic of heart failure. In patients hospitalized with heart failure, HFpEF is now as common as heart failure with reduced ejection fraction. We now have many successful treatments for hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2b6691099d57f0b5badd553aaefc11
http://hdl.handle.net/11591/405959
http://hdl.handle.net/11591/405959
Autor:
Soo Min Kim, Wei Li, Daniel G. Anderson, Richard T. Lee, Patrick Guye, James R. Pancoast, Ron Weiss, Minglin Ma, Samuel Lee, Paula T. Hammond
Publikováno v:
Scientific Reports
Nature Publishing Group
Nature Publishing Group
Diabetes is caused by the loss or dysfunction of insulin-secreting β-cells in the pancreas. β-cells reduce their mass and lose insulin-producing ability in vitro, likely due to insufficient cell-cell and cell-extracellular matrix (ECM) interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3c91f7529ae072de3f6c1edd4f22b3
http://europepmc.org/articles/PMC3790197
http://europepmc.org/articles/PMC3790197
Publikováno v:
Circulation research. 113(2)
Aging is a major factor in many cardiovascular diseases. The molecular factors that regulate age-related changes in cardiac physiology and contribute to the increased cardiovascular risk in the elderly are not fully understood. A study recently publi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c4fbf4f24f643afee7e21261754368
https://pubmed.ncbi.nlm.nih.gov/23426265
https://pubmed.ncbi.nlm.nih.gov/23426265