Zobrazeno 1 - 10
of 46
pro vyhledávání: '"James R. Neely"'
Publikováno v:
Acta Medica Scandinavica. 199:9-15
Control of glycolysis and fatty acid oxidation in ischemic myocardium was studied in isolated working rat hearts. Coronary flow was reduced to the whole heart. In ischemic tissue, oxygen consumption, glycolysis and fatty acid oxidation all decreased
Publikováno v:
Cardiovascular Research. 27:396-402
Objective: The aim was to examine the effect on cardiac function, energy metabolism, and calcium uptake of either prostaglandin I2 (PGI2, prostacyclin) or prostaglandin F2α (both 28.6 nM) on the response of isolated rat hearts to 25 min of total glo
Autor:
H E Morgan, James R. Neely
Publikováno v:
Annual review of physiology. 36
Autor:
James R. Neely, Masato Tani
Publikováno v:
Journal of Molecular and Cellular Cardiology. 22:57-72
Maintenance of low coronary flow (1 ml/min) during 40 or 70 min of anoxia maintained function and prevented Ca2+ overload during reoxygenation in isolated rat hearts. In comparison, recovery from 40 min of global ischemia resulted in only 20% of prei
Publikováno v:
The Annals of thoracic surgery. 52(4)
Working rat hearts were perfused for 15 minutes at 37 °C before switching to a Langendorff perfusion (60 mm Hg aortic pressure) at 10 °C for 40 minutes of hypothermic arrest. Ventricular function was allowed to recover for 15 minutes at 37 °C by r
Publikováno v:
Journal of molecular and cellular cardiology. 22(3)
Transport and metabolism of [3H]pantothenic acid ([3H]Pa) was investigated in hearts from control and streptozotocin-induced diabetic rats. In isolated perfused hearts from control animals, the transport of [3H]Pa was linear over 3 h of perfusion whe
Autor:
James R. Neely, Hideaki Yosino
Publikováno v:
Journal of Molecular and Cellular Cardiology. 22:S41
Publikováno v:
Journal of Biological Chemistry. 253:4305-4309
The effects of whole heart ischemia on fatty acid metabolism were studied in the isolated, perfused rat heart. A reduction in coronary flow and oxygen consumption resulted in lower rates of palmitate uptake and oxidation to CO2. This decrease in meta
Publikováno v:
Journal of Molecular and Cellular Cardiology. 9:353-364
Whole-heart ischemia was induced in isolated working rat hearts developing 75 to 90 mm Hg peak systolic pressures A decline in peak systolic pressure to 30 mm Hg was chosen to represent ventricular failure. For light and electron microscopy, hearts w
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 69:190-195
Intracoronary injection of 14 meg. of tetrodotoxin into the ischemic isolated rat heart resulted in immediate cessation of mechanical activity. Upon reperfusion with oxygenated, modified Krebs-Henseleit bicarbonate buffer in a modified Langendorff ap