Zobrazeno 1 - 10
of 11
pro vyhledávání: '"James R. Mortimer"'
Autor:
Anne-Marie Pulichino, James R. Mortimer, I-Ming Wang, Yves Boie, Jack A. Elias, Lijing Xu, Anick Auger, Alexandre Caron, Camil E. Sayegh, Aileen Kartono, Joseph Menetski
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 39:324-336
Lung fibrosis is characterized by excessive accumulation of extracellular matrix components leading to progressive airflow limitation. Distinct profibrotic pathways converge on the activation of transforming growth factor-beta (TGF-beta), a central g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b812b6b7a34b6761ad5d78a31c1e1519
https://doi.org/10.1165/rcmb.2007-0186oc
https://doi.org/10.1165/rcmb.2007-0186oc
Publikováno v:
Journal of Theoretical Biology. 208:475-491
For double-stranded RNA (dsRNA) to signal the presence of foreign (non-self) nucleic acid, self-RNA–self-RNA interactions should be minimized. Indeed, self-RNAs appear to have been fine-tuned over evolutionary time by the introduction of purines in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20d53fad17ee566fb7769573e99d6e0
https://doi.org/10.1006/jtbi.2000.2233
https://doi.org/10.1006/jtbi.2000.2233
Autor:
Silvija Coulter, James R. Mortimer, I-Ming Wang, Yves Boie, Michael A. Crackower, Richard Raubertas, Christopher J. Roberts, Sandra Cervino, Gary P. O'Neill, Leanna Loy, Michele Thornton, Shizu Hayashi, Peter D. Paré, Sergey B. Stepaniants, Mark Elliott, Jennifer R. Harris, Brian P. Kennedy, Jim C Hogg
Publikováno v:
American journal of respiratory and critical care medicine. 177(4)
Chronic obstructive lung disease (COPD) is a common and disabling lung disease for which there are few therapeutic options.We reasoned that gene expression profiling of COPD lungs could reveal previously unidentified disease pathways.Forty-eight huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5164e3678c1e8561bf6db2af2480e7b2
https://pubmed.ncbi.nlm.nih.gov/18250352
https://pubmed.ncbi.nlm.nih.gov/18250352
Autor:
James R. Mortimer
Publikováno v:
American journal of respiratory cell and molecular biology. 34(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929815bde180a8162a1472523df58ed4
https://pubmed.ncbi.nlm.nih.gov/15947424
https://pubmed.ncbi.nlm.nih.gov/15947424
Autor:
Paul Perco, David J. Arenillas, Wyeth W. Wasserman, Debra L. Fulton, Shao Shan Huang, James R. Mortimer, Shannan J. Ho Sui
Publikováno v:
APBC
Transcription regulation is mediated by combinatorial interactions between diverse trans-acting proteins and arrays of cis-regulatory sequences. Revealing this complex interplay between transcription factors and binding sites remains a fundamental pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85f1deb626bc5e87df3526dad6a7f0a6
https://doi.org/10.1142/9781860947292_0028
https://doi.org/10.1142/9781860947292_0028
oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes
Autor:
Brian P. Kennedy, Shannan J. Ho Sui, David J. Arenillas, Wyeth W. Wasserman, James R. Mortimer, Christopher J. Walsh, Jochen Brumm
Publikováno v:
Nucleic Acids Research
Targeted transcript profiling studies can identify sets of co-expressed genes; however, identification of the underlying functional mechanism(s) is a significant challenge. Established methods for the analysis of gene annotations, particularly those
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77829974937b89d8322c1e9d9c057e45
https://pubmed.ncbi.nlm.nih.gov/15933209
https://pubmed.ncbi.nlm.nih.gov/15933209
Publikováno v:
Applied bioinformatics. 3(4)
Wada and colleagues have shown that, whether prokaryotic or eukaryotic, each gene has a ‘homostabilising propensity’ to adopt a relatively uniform GC percentage (GC%). Accordingly, each gene can be viewed as a ‘microisochore’ occupying a disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a827b00577e2a35203ac2520afcea87
https://pubmed.ncbi.nlm.nih.gov/15702952
https://pubmed.ncbi.nlm.nih.gov/15702952
Autor:
James R, Mortimer, Donald R, Forsdyke
Publikováno v:
Applied bioinformatics. 2(1)
Differences in the base composition of genomes can occur because of GC pressure, purine-loading pressure (AG pressure) and RNY pressure, for which there are possible functional explanations, and because of the more abstract pressures exerted by indiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad8c267bbe90fdb43bd75045133e3999
https://pubmed.ncbi.nlm.nih.gov/15130833
https://pubmed.ncbi.nlm.nih.gov/15130833
Publikováno v:
Extremophiles : life under extreme conditions. 7(6)
The purine-loading index (PLI) is the difference between the numbers of purines (A+G) and pyrimidines (T+C) per kilobase of single-stranded nucleic acid. By purine-loading their mRNAs organisms may minimize unnecessary RNA–RNA interactions and prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a013aaee33185078bb19fc1d22c803
https://pubmed.ncbi.nlm.nih.gov/14666404
https://pubmed.ncbi.nlm.nih.gov/14666404
Autor:
Marie-Claude Mathieu, Alex G. Therien, Virginie Bernier, Yves Boie, Danielle Denis, Simon Lord-Dufour, Jason Burch, Yongxin Han, James R. Mortimer, Patsy Clark
Publikováno v:
Cytokine. 43:257-258
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c31869b5185677eceffd5feebfef67b
https://doi.org/10.1016/j.cyto.2008.07.134
https://doi.org/10.1016/j.cyto.2008.07.134