Zobrazeno 1 - 10
of 23
pro vyhledávání: '"James R. Manning"'
Autor:
Paul H. Wen, Stephen J. Wood, Qingyian Liu, Aaron C. Siegmund, Liping H. Pettus, Adrian Nanez, Matthew P. Bourbeau, Jennifer R. Allen, Michael D. Bartberger, Douglas A. Whittington, Jodi Bradley, James R. Manning, Kui Chen, Dean Hickman, Michael E. Johnson
Publikováno v:
Journal of medicinal chemistry. 63(5)
β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is an aspartyl protease that plays a key role in the production of amyloid β (Aβ) in the brain and has been extensively pursued as a target for the treatment of Alzheimer's disease (AD). B
Autor:
Huw M. L. Davies, James R. Manning
Publikováno v:
Tetrahedron. 64:6901-6908
Studies related to the total synthesis of elisabethin C led to the discovery of a rhodium-catalyzed cascade sequence involving isoxazole ring expansion and a [4 + 3] cycloaddition. The scope of the isoxazole ring expansion was explored, resulting in
Autor:
Huw M. L. Davies, James R. Manning
Publikováno v:
Nature. 451:417-424
Novel reactions that can selectively functionalize carbon-hydrogen bonds are of intense interest to the chemical community because they offer new strategic approaches for synthesis. A very promising 'carbon-hydrogen functionalization' method involves
The aza-Cope-Mannich reaction and ring-closing metathesis are key steps in the assembly of intermediates containing rings A−D of Daphniphyllum alkaloids of the daphnicyclidin type such as daphnipaxinin and oldhamine A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2293fa117ea2383184a9d40509fb32f
https://europepmc.org/articles/PMC2996462/
https://europepmc.org/articles/PMC2996462/
Publikováno v:
ChemInform. 40
A series of enantiomerically pure 1-naphthyl and 4-indolyl arylalkylamines were prepared and evaluated for their binding affinities to the monoamine transporters. The two series of enantiomers displayed considerable differences in binding selectivity
Autor:
Huw M. L. Davies, James R. Manning
Publikováno v:
ChemInform. 40
Autor:
James R, Manning, Huw M L, Davies
Publikováno v:
Tetrahedron. 64(29)
Studies related to the total synthesis of elisabethin C led to the discovery of a rhodium-catalyzed cascade sequence involving isoxazole ring expansion and a [4 + 3] cycloaddition. The scope of the isoxazole ring expansion was explored, resulting in
Autor:
James R. Manning, Huw M. L. Davies
Publikováno v:
ChemInform. 39
A concise one-pot synthesis of highly functionalized pyridines has been developed. The first step in the reaction sequence is the formal insertion of rhodium vinylcarbenoids across the N−O bond of isoxazoles. Upon heating, the insertion products un
Autor:
James R. Manning, Huw M. L. Davies
Publikováno v:
e-EROS Encyclopedia of Reagents for Organic Synthesis
[126554-35-6] C5H6N2O2 (MW 126) InChI = 1S/C5H6N2O2/c1-3-4(7-6)5(8)9-2/h3H,1H2,2H3 InChIKey = RCHAWIWORXGKLB-UHFFFAOYSA-N (precursor to highly chemoselective metal carbenoids) Physical Data: IR (neat) 2082, 1695, 1610 cm−1; 1H NMR (CDCl3) δ6.15 (d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c587827960a61a1505aefa99aedb809
https://doi.org/10.1002/047084289x.rn00898
https://doi.org/10.1002/047084289x.rn00898