Zobrazeno 1 - 10
of 120
pro vyhledávání: '"James R. Lepock"'
Autor:
Michael L. Freeman, Joseph L. Roti Roti, James R. Lepock, Peter A. Crooks, Michael J. Borrelli, Robert G. Bristow, Ryuji Higashikubo, Nobuo Horikoshi, Jamil Sawani, Andrei Laszlo, Soumya Sasi, Venkatraj Muthusamy, Vijayakumar N. Sonar, Konjeti R. Sekhar
Supplementary Methods from Novel Chemical Enhancers of Heat Shock Increase Thermal Radiosensitization through a Mitotic Catastrophe Pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b11e3998223fa839248d54cc1751341
https://doi.org/10.1158/0008-5472.22366368
https://doi.org/10.1158/0008-5472.22366368
Autor:
Michael L. Freeman, Joseph L. Roti Roti, James R. Lepock, Peter A. Crooks, Michael J. Borrelli, Robert G. Bristow, Ryuji Higashikubo, Nobuo Horikoshi, Jamil Sawani, Andrei Laszlo, Soumya Sasi, Venkatraj Muthusamy, Vijayakumar N. Sonar, Konjeti R. Sekhar
Supplementary Figures 1-9 from Novel Chemical Enhancers of Heat Shock Increase Thermal Radiosensitization through a Mitotic Catastrophe Pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8812f467b851a2d4009bc00fdc5553
https://doi.org/10.1158/0008-5472.22366371.v1
https://doi.org/10.1158/0008-5472.22366371.v1
Autor:
Michael L. Freeman, Joseph L. Roti Roti, James R. Lepock, Peter A. Crooks, Michael J. Borrelli, Robert G. Bristow, Ryuji Higashikubo, Nobuo Horikoshi, Jamil Sawani, Andrei Laszlo, Soumya Sasi, Venkatraj Muthusamy, Vijayakumar N. Sonar, Konjeti R. Sekhar
Radiation therapy combined with adjuvant hyperthermia has the potential to provide outstanding local-regional control for refractory disease. However, achieving therapeutic thermal dose can be problematic. In the current investigation, we used a chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1baa1efcc3556d497da7d07a64c144ba
https://doi.org/10.1158/0008-5472.c.6495111
https://doi.org/10.1158/0008-5472.c.6495111
Autor:
Abhijit Guha, Michael J. Borrelli, Avijit Chakrabartty, Kevin C. Hadley, Sidney Croul, JoAnne McLaurin, James R. Lepock
Publikováno v:
Cell Stress and Chaperones. 16:549-561
The inability of cells to maintain protein folding homeostasis is implicated in the development of neurodegenerative diseases, malignant transformation, and aging. We find that multiphoton fluorescence imaging of 1-anilinonaphthalene-8-sulfonate (ANS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1d017bd95aca8b65f58c35d4814b58
https://doi.org/10.1007/s12192-011-0266-6
https://doi.org/10.1007/s12192-011-0266-6
Publikováno v:
Journal of Molecular Biology. 385:278-298
More than 110 mutations in dimeric, Cu,Zn superoxide dismutase (SOD) have been linked to the fatal neurodegenerative disease, amyotrophic lateral sclerosis (ALS). In both human patients and mouse model studies, protein misfolding has been implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e653eb86b08f3ecdc7283c1e95ca6809
https://doi.org/10.1016/j.jmb.2008.10.003
https://doi.org/10.1016/j.jmb.2008.10.003
Autor:
Vijayakumar N. Sonar, Venkatraj Muthusamy, Soumya Sasi, Joseph L. Roti Roti, Ryuji Higashikubo, Michael J. Borrelli, Andrei Laszlo, Peter A. Crooks, Michael L. Freeman, Nobuo Horikoshi, Konjeti R. Sekhar, James R. Lepock, Jamil Sawani, Robert G. Bristow
Publikováno v:
Cancer Research. 67:695-701
Radiation therapy combined with adjuvant hyperthermia has the potential to provide outstanding local-regional control for refractory disease. However, achieving therapeutic thermal dose can be problematic. In the current investigation, we used a chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ff15d6c96f3c1c5de1daf06ad7038d
https://doi.org/10.1158/0008-5472.can-06-3212
https://doi.org/10.1158/0008-5472.can-06-3212
Autor:
Farhad Karbassi, Elizabeth M. Meiering, Clare A. Siddall, Jessica A.O. Rumfeldt, James R. Lepock, Peter B. Stathopulos
Publikováno v:
Journal of Biological Chemistry. 281:6184-6193
Differential scanning calorimetry was used to measure changes in thermodynamic stability and aggregation for glycine 93 mutants of human copper, zinc-superoxide dismutase (SOD). Glycine 93 is a conserved residue at position i + 3 of a tight turn and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3d26bec53249ccf5de6888a7f2619c
https://doi.org/10.1074/jbc.m509496200
https://doi.org/10.1074/jbc.m509496200
Autor:
Peter B. Stathopulos, Jessica A.O. Rumfeldt, Elizabeth M. Meiering, Avijit Chakrabarrty, James R. Lepock
Publikováno v:
Journal of Molecular Biology. 355:106-123
Mutations in human copper zinc superoxide dismutase (hSOD) that are associated with amyotrophic lateral sclerosis (ALS) have been proposed to destabilize the protein and thereby enhance toxic protein aggregation. In previous studies, denaturation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abd04116642a770ddff1381cece79de
https://doi.org/10.1016/j.jmb.2005.10.042
https://doi.org/10.1016/j.jmb.2005.10.042
Autor:
James R. Lepock
Publikováno v:
International Journal of Hyperthermia. 21:681-687
Changes in growth temperature induce both activating and inactivating responses from cells, with the magnitude of the temperature change being among the factors that influence which type of response dominates. Aside from upregulated enzyme activity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e75860badc3745f08d3e132b21c8dc
https://doi.org/10.1080/02656730500307298
https://doi.org/10.1080/02656730500307298
Autor:
James R. Lepock
Publikováno v:
Methods. 35:117-125
Many methods exist for measuring and studying protein denaturation in vitro. However, measuring protein denaturation in cells under conditions relevant to heat shock presents problems due to cellular complexity and high levels of light scattering tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d924f6f7e5f0bf471e04c3a2c93415de
https://doi.org/10.1016/j.ymeth.2004.08.002
https://doi.org/10.1016/j.ymeth.2004.08.002