Výsledky vyhledávání - "James R. Lambert"

Akademický článek

A Novel Regimen for Treating Melanoma: MCL1 Inhibitors and Azacitidine

Autor: Chiara R. Dart, Nabanita Mukherjee, Carol M. Amato, Anabel Goulding, Morgan MacBeth, Robert Van Gulick, Kasey L. Couts, James R. Lambert, David A. Norris, William A. Robinson, Yiqun G. Shellman

Publikováno v: Pharmaceuticals, Vol 14, Iss 8, p 749 (2021)

Although treatment options for melanoma patients have expanded in recent years with the approval of immunotherapy and targeted therapy, there is still an unmet need for new treatment options for patients that are ineligible for, or resistant to these

Externí odkaz: https://doaj.org/article/8df2317343b64fa7a9ed2dd89c7c4fa3

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Akademický článek

A role for the non-conserved N-terminal domain of the TATA-binding protein in the crosstalk between cell signaling pathways and steroid receptors

Autor: James R. Lambert, Steven K. Nordeen

Publikováno v: AIMS Molecular Science, Vol 2, Iss 2, Pp 64-76 (2015)

Transcriptional induction by steroid receptors is coupled to cellular signal transduction pathways although, in general, the mechanisms governing these events are not well defined. Using TATA-binding protein (TBP) specificity mutants that recognize a

Externí odkaz: https://doaj.org/article/b0ee07202da442eda2d80f6e0772e819

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Akademický článek

Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease

Autor: Paula A. Desplats, James R. Lambert, Elizabeth A. Thomas

Publikováno v: Neurobiology of Disease, Vol 31, Iss 3, Pp 298-308 (2008)

Transcriptional dysregulation has emerged as a central pathogenic mechanism in Huntington's disease (HD), which is associated with neuropathological changes predominantly in the striatum. Here we demonstrate that expression of Bcl11b (a.k.a. CTIP2),

Externí odkaz: https://doaj.org/article/0999d2b56e444c16a986c21971932222

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