Zobrazeno 1 - 10
of 178
pro vyhledávání: '"James R. Kincaid"'
Autor:
Dayna C Patterson, Emily E. Weinert, Yilin Liu, Neela H. Yennawar, James R. Kincaid, Sayan Das, Jean Paul Armache
Publikováno v:
Biochemistry. 60:3801-3812
Bifunctional enzymes, which contain two domains with opposing enzymatic activities, are widely distributed in bacteria, but the regulatory mechanism(s) that prevent futile cycling are still poorly understood. The recently described bifunctional enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cc6cceed23eb0c77eda3e5117a1063
https://doi.org/10.1021/acs.biochem.1c00581
https://doi.org/10.1021/acs.biochem.1c00581
Autor:
Ilia G. Denisov, Stephen G. Sligar, Michael C. Gregory, Yilin Liu, Yelena V. Grinkova, James R. Kincaid
Publikováno v:
Biochemistry
Steroid metabolism in humans originates from cholesterol and involves several enzyme reactions including dehydrogenation, hydroxylation, and carbon–carbon bond cleavage that occur at regio- and stereo-specific points in the four-membered ring struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547aff033426072361c5f67408b05fc8
https://doi.org/10.1021/acs.biochem.1c00282
https://doi.org/10.1021/acs.biochem.1c00282
Publikováno v:
Journal of the American Chemical Society. 143:3729-3733
CYP17A1 is an essential human steroidogenic enzyme, which catalyzes two sequential reactions leading to the formation of androstenedione from progesterone and dehydroepiandrosterone from pregnenolone. The second reaction is the C17-C20 bond scission,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8462e442bcfd02bf69d7041f5a988dd
https://doi.org/10.1021/jacs.1c00581
https://doi.org/10.1021/jacs.1c00581
Publikováno v:
Journal of Inorganic Biochemistry. 242:112167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f93493d4a6bea54aba9df6929e0bb0d
https://doi.org/10.1016/j.jinorgbio.2023.112167
https://doi.org/10.1016/j.jinorgbio.2023.112167
Publikováno v:
Journal of Inorganic Biochemistry. 241:112126
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cce02e544a4bb424d584cfec06f47cc8
https://doi.org/10.1016/j.jinorgbio.2023.112126
https://doi.org/10.1016/j.jinorgbio.2023.112126
Publikováno v:
Chemistry
Human cytochrome P450 CYP17A1 first catalyzes hydroxylation at the C17 position of either pregnenolone (PREG) or progesterone (PROG), and a subsequent C(17)–C(20) bond scission to produce dehydroepiandrosterone (DHEA) or androstenedione (AD). In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfdf31d6d0dc3faed356d25c2afbe6b
https://doi.org/10.1002/chem.202003181
https://doi.org/10.1002/chem.202003181
When subjected to γ-irradiation at cryogenic temperatures the oxygenated complexes of Cytochrome P450 17A1 bound with either of the lyase substrates, 17-OH PREG or 17-OH PROG are shown here to generate the corresponding lyase products, dehydroepiand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baa49eb280ea94755f58fbc5a0f5ed4f
https://doi.org/10.33774/chemrxiv-2021-r67s4
https://doi.org/10.33774/chemrxiv-2021-r67s4
Publikováno v:
J Am Chem Soc
CYP17A1 is an essential human steroidogenic enzyme, which catalyzes two sequential reactions leading to the formation of androstenedione from progesterone and dehydroepiandrosterone from pregnenolone. The second reaction is the C17-C20 bond scission,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2648632e5b632dd56090bd4fb315a4f
https://pubmed.ncbi.nlm.nih.gov/33656879
https://pubmed.ncbi.nlm.nih.gov/33656879
Autor:
James R. Kincaid
Publikováno v:
Our Monica, Ourselves ISBN: 9780814739280
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b96b01c1e765ad182629dbfd7116c0fe
https://doi.org/10.18574/nyu/9780814739280.003.0008
https://doi.org/10.18574/nyu/9780814739280.003.0008
Autor:
James R. Kincaid
Publikováno v:
The Children's Culture Reader ISBN: 9780814743782
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f4e685cea423ed96c4beac80e914f54
https://doi.org/10.18574/nyu/9780814743782.003.0017
https://doi.org/10.18574/nyu/9780814743782.003.0017