Zobrazeno 1 - 10
of 10
pro vyhledávání: '"James R. Hinshaw"'
Autor:
Karl F. Freed, John M. Jumper, Adam M. Zmyslowski, Micayla A. Bowman, Tobin R. Sosnick, Emily B. Kaye, Joshua A. Riback, James R. Hinshaw, Catherine R. Knoverek, Patricia L. Clark
Publikováno v:
Science
An expanded view of disordered proteins Disordered proteins sample an ensemble of conformations, but it has remained unclear how compact these conformations are in water. Polymer physics relates the radius of gyration ( R g ) to solvent quality, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bac96d64670b9e2188a08b9424e476
https://doi.org/10.1126/science.aan5774
https://doi.org/10.1126/science.aan5774
Autor:
Gaetano T. Montelione, David Baker, Benjamin Basanta, Patrick Barth, Rong Xiao, Tobin R. Sosnick, Tiffany King, John Everett, Gaohua Liu, James R. Hinshaw, Kui K. Chan
Publikováno v:
Protein Science. 25:1299-1307
Design of polar interactions is a current challenge for protein design. The de novo designed protein Top7, like almost all designed proteins, has an entirely nonpolar core. Here we describe the replacing of a sizable fraction (5 residues) of this cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ac84e9f4bdaaa7d9e65ad87241566e4
https://doi.org/10.1002/pro.2899
https://doi.org/10.1002/pro.2899
Autor:
John J. Skinner, Michael C. Baxa, Wookyung Yu, Tobin R. Sosnick, Karl F. Freed, Elizabeth K. Gichana, James R. Hinshaw
Publikováno v:
Proceedings of the National Academy of Sciences. 111:15975-15980
Long-time molecular dynamics (MD) simulations are now able to fold small proteins reversibly to their native structures [Lindorff-Larsen K, Piana S, Dror RO, Shaw DE (2011) Science 334(6055):517-520]. These results indicate that modern force fields c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61dc71db880cc694b3c7f1ad867b0df7
https://doi.org/10.1073/pnas.1404213111
https://doi.org/10.1073/pnas.1404213111
Autor:
Patricia L. Clark, Tobin R. Sosnick, Adam M. Zmyslowski, Micayla A. Bowman, James R. Hinshaw, Catherine R. Knoverek, Karl F. Freed, Emily B. Kaye, Joshua A. Riback, John M. Jumper
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 74:a221-a221
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca20ca2f5e8a8be14a121650aa68b19a
https://doi.org/10.1107/s0108767318097787
https://doi.org/10.1107/s0108767318097787
Autor:
Benjamin, Basanta, Kui K, Chan, Patrick, Barth, Tiffany, King, Tobin R, Sosnick, James R, Hinshaw, Gaohua, Liu, John K, Everett, Rong, Xiao, Gaetano T, Montelione, David, Baker
Publikováno v:
Protein science : a publication of the Protein Society. 25(7)
Design of polar interactions is a current challenge for protein design. The de novo designed protein Top7, like almost all designed proteins, has an entirely nonpolar core. Here we describe the replacing of a sizable fraction (5 residues) of this cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70a73f61d540bb31ff42c01c6a556733
https://pubmed.ncbi.nlm.nih.gov/26873166
https://pubmed.ncbi.nlm.nih.gov/26873166
Measuring the (Good) Solvent Quality of Water for Disordered Proteins from a Single SAXS Measurement
Autor:
Patricia L. Clark, Micayla A. Bowman, Joshua A. Riback, Catherine R. Knoverek, Karl F. Freed, James R. Hinshaw, Tobin R. Sosnick, Adam M. Zmyslowski, Emily B. Kaye, John M. Jumper
Publikováno v:
Biophysical Journal. 112:316a
Significance: Proteins adopt non-native geometries during their synthesis, folding, transport, and turnover and a significant fraction of the proteome is intrinsically disordered. The characterization of disordered proteins is challenging in part due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5faa82604f3b2041410d4b0e71c38be
https://doi.org/10.1016/j.bpj.2016.11.1712
https://doi.org/10.1016/j.bpj.2016.11.1712
Autor:
Adrienne C. Dlouhy, Haoran Li, Ruslan Sanishvili, Chuan He, Caryn E. Outten, James R. Hinshaw, Catherine B. Poor, Seraphine V. Wegner, Jonathan P. Schuermann, Pamela J. Riggs-Gelasco
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(11)
The paralogous iron-responsive transcription factors Aft1 and Aft2 (activators of ferrous transport) regulate iron homeostasis in Saccharomyces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron is low. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d5da48d75a16faeba1e419892c700d
https://pubmed.ncbi.nlm.nih.gov/24591629
https://pubmed.ncbi.nlm.nih.gov/24591629
Kinetic folding of the large two-domain maltose binding protein (MBP; 370 residues) was studied at high structural resolution by an advanced hydrogen-exchange pulse-labeling mass-spectrometry method (HX MS). Dilution into folding conditions initiates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71e77965766ea095b0f5c967938c4c6
https://europepmc.org/articles/PMC3839771/
https://europepmc.org/articles/PMC3839771/
Autor:
Tobin R. Sosnick, James R. Hinshaw
Publikováno v:
Science. 334:464-465
Two reports in this issue probe single protein chains as they spontaneously unfold and refold. On page 517 of this issue, Lindorff-Larsen et al. ( 1 ) use state-of-the-art molecular dynamics (MD) simulations to elucidate the folding mechanisms of 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::508841f45e2c136958f50ab303a820ca
https://doi.org/10.1126/science.1214018
https://doi.org/10.1126/science.1214018
Autor:
James R. Hinshaw, Esmael J. Haddadian, Abhishek K. Jha, Karl F. Freed, Phoebe A. Rice, Haipeng Gong, Xiaojing Yang, Joe DeBartolo, Tobin R. Sosnick
Publikováno v:
Biophysical Journal. (4):899-909
Crystals of many important biological macromolecules diffract to limited resolution, rendering accurate model building and refinement difficult and time-consuming. We present a torsional optimization protocol that is applicable to many such situation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e3299823e8c88d8d1ee5b443674c68