Zobrazeno 1 - 10
of 11
pro vyhledávání: '"James R. Hilaire"'
Autor:
Prasanta K. Dash, Rafal Kaminski, Ramona Bella, Hang Su, Saumi Mathews, Taha M. Ahooyi, Chen Chen, Pietro Mancuso, Rahsan Sariyer, Pasquale Ferrante, Martina Donadoni, Jake A. Robinson, Brady Sillman, Zhiyi Lin, James R. Hilaire, Mary Banoub, Monalisha Elango, Nagsen Gautam, R. Lee Mosley, Larisa Y. Poluektova, JoEllyn McMillan, Aditya N. Bade, Santhi Gorantla, Ilker K. Sariyer, Tricia H. Burdo, Won-Bin Young, Shohreh Amini, Jennifer Gordon, Jeffrey M. Jacobson, Benson Edagwa, Kamel Khalili, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Here, the authors show that sequential treatment with long-acting slow-effective release ART and AAV9- based delivery of CRISPR-Cas9 results in undetectable levels of virus and integrated DNA in a subset of humanized HIV-1 infected mice. This proof-o
Externí odkaz:
https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b
Autor:
Dhruvkumar Soni, Wenting Zhang, Brendan M. Ottemann, Jatin Machhi, JoEllyn M McMillan, Kristen N. Sikora, R. Lee Mosley, Jered C. Garrison, Insiya Mukadam, Howard E. Gendelman, Bhavesh D. Kevadiya, James R. Hilaire, Mahmudul Hasan, Laura Castellanos, Sarella Anandakumar, Jonathan Herskovitz, Benson J Edagwa, Richard W. Vachet
Publikováno v:
Theranostics
Human immunodeficiency virus theranostics facilitates the development of long acting (LA) antiretroviral drugs (ARVs) by defining drug-particle cell depots. Optimal drug formulations are made possible based on precise particle composition, structure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75ce12fbe6ad81aa90594d62ee080e6
https://doi.org/10.7150/thno.39847
https://doi.org/10.7150/thno.39847
Autor:
Santhi Gorantla, James R. Hilaire, Won Bin Young, Shohreh Amini, JoEllyn M McMillan, Brady Sillman, Chen Chen, Hang Su, Mary G. Banoub, Kamel Khalili, Howard E. Gendelman, Prasanta K. Dash, Jennifer Gordon, Larisa Y. Poluektova, Nagsen Gautam, Martina Donadoni, Rahsan Sariyer, Pietro Mancuso, Saumi Mathews, Rafal Kaminski, Monalisha Elango, R. Lee Mosley, Tricia H. Burdo, Jeffrey M. Jacobson, Benson J Edagwa, Taha Mohseni Ahooyi, Pasquale Ferrante, Jake A. Robinson, Zhiyi Lin, Ramona Bella, Ilker Kudret Sariyer, Aditya N. Bade
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Nature Communications
Nature Communications
Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective release antiviral therapy (LASER ART) and CRISPR-Cas9 demonstrate viral clearance in latent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27b73c3e4c0b82ed8decf5430a2d869
https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b
https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b
Autor:
Javier Seravalli, James R. Hilaire, Yutong Liu, Brendan M. Ottemann, Jatin Machhi, JoEllyn M McMillan, Anandakumar Sarella, Bhavesh D. Kevadiya, Mahmudul Hasan, Christopher Woldstad, Insiya Mukadam, Howard E. Gendelman, Jonathan Herskovitz
Publikováno v:
Nanotheranostics
Background: Delivery of long-acting nanoformulated antiretroviral drugs (ARVs) to human immunodeficiency virus type one cell and tissue reservoirs underlies next generation antiretroviral therapeutics. Nanotheranostics, comprised of trackable nanopar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b593047505946e0bf1ee7b90dfc25478
https://pubmed.ncbi.nlm.nih.gov/33972918
https://pubmed.ncbi.nlm.nih.gov/33972918
Autor:
Brady Sillman, Tai-Yuen Yue, Howard E. Gendelman, Nagsen Gautam, Melinda Wojtkiewicz, R. Lee Mosley, Adam M. Szlachetka, Bhagya Laxmi Dyavar Shetty, Sruthi Sravanam, Howard S. Fox, Jane L. Meza, Yazen Alnouti, James R. Hilaire, Aditya N. Bade, Tanmay A. Kulkarni, Paul L. Domanico, Benson J Edagwa, Brenda Morsey, Benjamin G. Lamberty, Gary Moore, JoEllyn M McMillan
Publikováno v:
Nature materials. 19(8)
Long-acting cabotegravir (CAB) extends antiretroviral drug administration from daily to monthly. However, dosing volumes, injection site reactions and health-care oversight are obstacles towards a broad usage. The creation of poloxamer-coated hydroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edce3d8d71ee6472b6755874ca83dc4b
https://pubmed.ncbi.nlm.nih.gov/32704135
https://pubmed.ncbi.nlm.nih.gov/32704135
Autor:
Yazen Alnouti, Howard E. Gendelman, Tian Zhou, James R. Hilaire, Zhiyi Lin, JoEllyn M McMillan, Diana L. Palandri, Nathan Smith, Xin Ming Liu, Pavan Puligujja, Benson J Edagwa, Mariluz Araínga, Nagsen Gautam
Publikováno v:
Nanomedicine
Aim: While the therapeutic potential for current long-acting (LA) antiretroviral therapy (ART) is undeniable, ligand-decorated nanoformulated LA-ART could optimize drug delivery to viral reservoirs. The development of decorated ART hinges, however, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305f1f69e0bb77f3896b968b09e5b122
https://doi.org/10.2217/nnm-2017-0381
https://doi.org/10.2217/nnm-2017-0381
Autor:
Melinda Wojtkiewicz, Nagsen Gautam, Brady Sillman, Jonathan Herskovitz, Benson J Edagwa, James R. Hilaire, Howard S. Fox, Sruthi Sravanam, Yazen Alnouti, Adam M. Szlachetka, Benjamin G. Lamberty, Howard E. Gendelman, JoEllyn M McMillan, Aditya N. Bade, Bhagya Laxmi Dyavar Shetty, Prasanta K. Dash
Publikováno v:
J Control Release
Antiretroviral therapy requires lifelong daily dosing to attain viral suppression, restore immune function, and improve quality of life. As a treatment alternative, long-acting (LA) antiretrovirals can sustain therapeutic drug concentrations in blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fec3ae992efa3b210529137caa07982
https://europepmc.org/articles/PMC6875695/
https://europepmc.org/articles/PMC6875695/
Autor:
Howard E. Gendelman, James R. Hilaire
Publikováno v:
Neuroimmune Pharmacology ISBN: 9783319440200
Recent advances in molecular neuroscience and neuropharmacology have improved our knowledge of the intricate mechanisms that define and treat infectious, immune and degenerative disorders of the brain and spinal cord. As our knowledge expands, treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bf77780af227ea4c418460fbcb7bf1d
https://doi.org/10.1007/978-3-319-44022-4_49
https://doi.org/10.1007/978-3-319-44022-4_49
Autor:
James R. Hilaire, Howard E. Gendelman
Publikováno v:
Neuroimmune Pharmacology ISBN: 9783319440200
Mononuclear phagocytes (MP; monocytes, macrophages, microglia and dendritic cells) are joined together based on common function and phenotypic properties. In regards to phagocytoic, interacellular killing, secretory, antigen presentation and mobility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bb9742bc0f22b916f6d09234d12a1e2
https://doi.org/10.1007/978-3-319-44022-4_12
https://doi.org/10.1007/978-3-319-44022-4_12
Autor:
Yazen Alnouti, Nagsen Gautam, Benson J Edagwa, Diana L. Palandri, JoEllyn M McMillan, Dhirender Singh, Howard E. Gendelman, James R. Hilaire
Publikováno v:
Nanomedicine (London, England). 11(15)
Aim: A myristoylated abacavir (ABC) prodrug was synthesized to extend drug half-life and bioavailability. Methods: Myristoylated ABC (MABC) was made by esterifying myristic acid to the drug's 5-hydroxy-cyclopentene group. Chemical composition, antire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a667cdce1b1472b0c74eb57ed741cd
https://pubmed.ncbi.nlm.nih.gov/27456759
https://pubmed.ncbi.nlm.nih.gov/27456759