Zobrazeno 1 - 10
of 43
pro vyhledávání: '"James R. Givens"'
Publikováno v:
Metabolism. 43:584-590
The high incidence of non-insulin-dependent diabetes mellitus (NIDDM) in women with polycystic ovarian syndrome (PCO) is believed to occur secondary to the insulin resistance associated with theirandrogenicity. In the present study, we have examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4aafc04c5428fb65a3358f14764359b
https://doi.org/10.1016/0026-0495(94)90200-3
https://doi.org/10.1016/0026-0495(94)90200-3
Publikováno v:
Diabetes. 40:693-700
It has been hypothesized that the androgens testosterone and dehydroepiandrosterone (DHEA) may have opposing actions on insulin sensitivity. To test this hypothesis, we selected patients with polycystic ovary syndrome (PCO) and hypertestosteronemia a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce80539c8d06cbe61c569d0c71966e77
https://doi.org/10.2337/diab.40.6.693
https://doi.org/10.2337/diab.40.6.693
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 70:1075-1081
The objective of this study was to define the relationship among the circulating insulin level (IRI), the MCR of dehydroepiandrosterone (MCR-D), and the production rate of DHEA (PR-D) in 10 women with the polycystic ovary syndrome and acanthosis nigr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4906efcc129097eff03ebd3f19fea94
https://doi.org/10.1210/jcem-70-4-1075
https://doi.org/10.1210/jcem-70-4-1075
Publikováno v:
Diabetes. 39:361-368
Using phytohemagglutinin-activated T lymphocytes, we studied possible mechanisms responsible for insulin resistance in patients with polycystic ovarian disease (PCO) and acanthosis nigricans (AN) by examining insulin binding to erythrocytes and activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4300547367ff4dac6801d6f9369653
https://doi.org/10.2337/diab.39.3.361
https://doi.org/10.2337/diab.39.3.361
Publikováno v:
Journal of the Society for Gynecologic Investigation. 1(1)
We hypothesized that intravenous dehydroepiandrosterone (DHEA) would decrease insulin resistance in normal and insulin-resistant women.Five insulin-resistant women diagnosed as having polycystic ovaries (PCO) with elevated testosterone and normal deh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3d6edde27e21b8e4bc36e75d1a3313
https://pubmed.ncbi.nlm.nih.gov/9419751
https://pubmed.ncbi.nlm.nih.gov/9419751
Publikováno v:
International Journal of Gynecology & Obstetrics. 42:224-224
OBJECTIVE: The purpose of our study was to further understand interrelationships between insulin, androgens, obesity, and apolipoprotein metabolism. STUDY DESIGN: In this University cross-sectional observational study for hypothesis generation, 53 wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc04f545569371c2afcf8fabcb23100
https://doi.org/10.1016/0020-7292(93)90674-l
https://doi.org/10.1016/0020-7292(93)90674-l
Publikováno v:
Steroids. 22:731-745
Clinical and biochemical investigation of a virilized woman has shown an adrenal cortical adenoma to be the source of elevated plasma testosterone levels and to be responsive to gonadotropin administration in vivo (Givens et al.) (2). In the present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e8331e8bde957aa48fda6ee8040a99f
https://doi.org/10.1016/0039-128x(73)90049-4
https://doi.org/10.1016/0039-128x(73)90049-4
Autor:
Sidney A. Coleman, Stewart A. Fish, James R. Givens, Winfred L. Wiser, Richard N. Andersen, Irwin J. Kerber
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 38:347-355
This report describes a 17-yr-old female who developed acanthosis nigricans, hirsutism and amenorrhea concurrently at age 15. Plasma androstenedione (A) was extremely elevated ranging from 3500 to 5000 ng/100 ml. Plasma testosterone (T) and urinary 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc77e01710367a131877fd44a74d70e
https://doi.org/10.1210/jcem-38-3-347
https://doi.org/10.1210/jcem-38-3-347
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 43:457-461
17beta-Hydroxysteroid oxidoreductase (17 beta-HOR) activity in testicular tissue from a male pseudohermaphrodite (MP) who had elevated plasma LH and androstenedione (A) levels, and normal dehydroepiandrosterone (DHA) levels was compared by in vitro s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6391723f2082a9ff69083cfb4353094f
https://doi.org/10.1210/jcem-43-2-457
https://doi.org/10.1210/jcem-43-2-457
Autor:
James G. Karas, Surat Komindr, Michael D. Stevens, Joyce B. Bittle, Bryan R. Kurtz, James R. Givens
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 63:860-864
The alpha ACTH-(1-24) threshold dose and the response slope were determined for cortisol (F), delta 4-androstenedione (A), and dehydroepiandrosterone (DHEA) in 10 normal and 16 obese eumenorrheic nonhirsute women matched for age. Each woman received
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c25ff339498ffcb04e452cb1da5cab
https://doi.org/10.1210/jcem-63-4-860
https://doi.org/10.1210/jcem-63-4-860