Zobrazeno 1 - 10
of 40
pro vyhledávání: '"James R. Falconer"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 675 (2024)
The transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) has the potential to overcome some of the major disadvantages relating to oral NSAID usage, such as gastrointestinal adverse events and compliance. However, the poor solubilit
Externí odkaz:
https://doaj.org/article/9fb07c84a764485986ffd78cf84b273c
Autor:
Madeleine S. A. Tan, Preeti Pandey, James R. Falconer, Dan J. Siskind, Alexandra Balmanno, Harendra S. Parekh
Publikováno v:
Gels, Vol 8, Iss 1, p 38 (2022)
(1) Background: Clozapine is the most effective antipsychotic. It is, however, associated with many adverse drug reactions. Nose-to-brain (N2B) delivery offers a promising approach. This study aims to develop clozapine-encapsulated thermosensitive so
Externí odkaz:
https://doaj.org/article/58cae52c10f84ce894b2a34a3b801b1a
Publikováno v:
Biology, Vol 10, Iss 6, p 481 (2021)
In this study, the optimal setup of supercritical fluid extraction (SFE) was designed and developed, leading to the quantitation of 11 distinct cannabinoids (cannabidivann (CBDV), tetrahydrocannabivann (THCV), cannabidiol (CBD), cannabigerol (CBG) ca
Externí odkaz:
https://doaj.org/article/7315c27189394cb2adaf8f3bd7ae11b5
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 18, Iss 5 (2015)
Proliposomes are stable drug carrier systems designed to form liposomes upon addition of an aqueous phase. In this review, current trends in the use of supercritical fluid (SCF) technologies to prepare proliposomes are discussed. SCF methods are used
Externí odkaz:
https://doaj.org/article/b7aa17ee16d744e5aa111086587dbde4
Autor:
Madeleine S. A. Tan, Preeti Pandey, Rink-Jan Lohman, James R. Falconer, Dan J. Siskind, Harendra S. Parekh
Publikováno v:
Molecular pharmaceutics. 19(11)
Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia. However, it causes many adverse drug reactions (ADRs), which lead to poor treatment outcomes. Nose-to-brain (N2B) drug delivery offers a promising approach to reduce
Autor:
Andrew K. Whittaker, Maree T. Smith, Felicity Y. Han, Tushar Kumeria, James R. Falconer, Weizhi Xu, Zonglan Zhao, Amirali Popat
Publikováno v:
Drug Delivery and Translational Research. 12:676-694
Ketamine in sub-anaesthetic doses has analgesic properties and an opioid-sparing effect. Intrathecal (i.t.) delivery of analgesics bypasses systemic metabolism and delivers the analgesic agent adjacent to the target receptors in the spinal cord and s
Autor:
James R. Falconer, Peter J. Cabot, Amirali Popat, Fekade B. Sime, Jason A. Roberts, Aun Raza, Tushar Kumeria, Shih Chen Ngieng
Publikováno v:
Drug Discovery Today. 26:551-560
An increase in the number of multidrug-resistant microbial strains is the biggest threat to global health and is projected to cause >10 million deaths by 2055. The carbapenem family of antibacterial drugs are an important class of last-resort treatme
Autor:
Jason A. Roberts, James R. Falconer, Aun Raza, Peter J. Cabot, Fekade B. Sime, Amirali Popat, Tushar Kumeria
Publikováno v:
ACS Biomaterials Science & Engineering. 7:1836-1853
Meropenem (MER) is an effective broad-spectrum antibiotic currently only available in the parenteral form requiring frequent drug preparation and administration due to its extremely poor stability. The unavailability of oral Meropenem is primarily du
Autor:
James R. Falconer, Tushar Kumeria, Yuxue Cao, Amirali Popat, Mark A. T. Blaskovich, John Ndayishimiye
Publikováno v:
Journal of Materials Chemistry B. 9:7145-7166
Vancomycin (Van) is a key antibiotic of choice for the treatment of systemic methicillin resistant Staphylococcus aureus (MRSA) infections. However, due to its poor membrane permeability, it is administered parenterally, adding to the cost and effort
Autor:
Jingyuan Wen, James R. Falconer, Nataly Martini, Michelle Locke, Zimei Wu, Mengyang Liu, Danhui Li
Publikováno v:
Journal of Drug Targeting. 29:310-322
Numerous skin disorders and diseases are related to oxidative stress. The application of an antioxidant, serving as a strong defense agent against oxidation, is of great interest in dermatology yet remains challenging for delivery. This paper aimed t