Zobrazeno 1 - 10
of 22
pro vyhledávání: '"James R. Engle"'
Autor:
Pengcheng Han, Megan Nielsen, Melissa Song, Junxiang Yin, Michele R. Permenter, Julie A. Vogt, James R. Engle, Brittany N. Dugger, Thomas G. Beach, Carol A. Barnes, Jiong Shi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Pituitary adenylate cyclase activating polypeptide (PACAP) is associated with Alzheimer’s disease (AD), but its age-related effects are unknown. We chose the rhesus macaque due to its closeness to human anatomy and physiology. We examined four vari
Externí odkaz:
https://doaj.org/article/d42264711aa34e8ebaa39b094ac165fb
Publikováno v:
Frontiers in Aging Neuroscience, Vol 5 (2013)
Subcortical auditory structures in the macaque auditory system increase their densities of neurons expressing the calcium binding protein parvalbumin (PV) with age. However, it is unknown whether these increases occur in the thalamic division of the
Externí odkaz:
https://doaj.org/article/c191d47581a34ee5b2cb0a0cc0db323b
Autor:
Sara N. Burke, Daniel T. Gray, Theodore P. Trouard, Nicole M. De La Peña, Carol A. Barnes, James R. Engle, Lavanya Umapathy
Publikováno v:
Cereb Cortex
Deficits in auditory function and cognition are hallmarks of normative aging. Recent evidence suggests that hearing-impaired individuals have greater risks of developing cognitive impairment and dementia compared to people with intact auditory functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a12cf8f68b779284bc12fe29eb3e9e
https://doi.org/10.1093/cercor/bhz275
https://doi.org/10.1093/cercor/bhz275
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55092 (2013)
Audiometric hearing deficits are a common symptom of age-related hearing loss (ARHL), as are specific histopathological changes in the cochlea; however, very little data have been collected in non-human primates. To examine this relationship further,
Externí odkaz:
https://doaj.org/article/4438761d28734f488789593801009445
Autor:
Sara N. Burke, Daniel T. Gray, Carol A. Barnes, Lavanya Umapathy, James R. Engle, Nicole M. De La Peña, Theodore P. Trouard
Publikováno v:
J Neurosci
Deficits in auditory and visual processing are commonly encountered by older individuals. In addition to the relatively well described age-associated pathologies that reduce sensory processing at the level of the cochlea and eye, multiple changes occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e44e4481cdd482c82966f0e0e73ccc1
https://europepmc.org/articles/PMC7659446/
https://europepmc.org/articles/PMC7659446/
Autor:
James R Engle, Carol A Barnes
Publikováno v:
Frontiers in Aging Neuroscience, Vol 4 (2012)
An overview is provided of the simple single-cue delay and trace eyeblink conditioning paradigms as techniques to assess associative learning and memory in the aged. We highlight and focus this review on the optimization of the parameter space of eye
Externí odkaz:
https://doaj.org/article/85aa0ae5c9944f7e937cf4bc099d31fc
Publikováno v:
Brain Injury. 32:1740-1748
Previous research suggests that saccadic eye movements can be uniquely sensitive to impairment in chronic traumatic brain injury (TBI). This study was conducted to examine saccadic eye movements across varying levels of cognitive load and TBI history
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62dd1db03593b139e1ee4c84956646f0
https://doi.org/10.1080/02699052.2018.1511067
https://doi.org/10.1080/02699052.2018.1511067
Autor:
Christopher J. Machado, Alicia M. Bulleri, Andrew P. Maurer, Carol A. Barnes, James R. Engle, Julie A. Vogt, Michele R. Permenter
Publikováno v:
The Journal of Neuroscience. 36:12217-12227
The ability to navigate through space involves complex interactions between multiple brain systems. Although it is clear that spatial navigation is impaired during aging, the networks responsible for these altered behaviors are not well understood. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ae358a08e5ea89307e7245c7d3e85c
https://doi.org/10.1523/jneurosci.4116-15.2016
https://doi.org/10.1523/jneurosci.4116-15.2016
Publikováno v:
Journal of Comparative Neurology. 522:4074-4084
Neurons expressing the calcium binding proteins (CaBPs) parvalbumin (PV) and calbindin (CB) have shown age-related density changes throughout the ascending auditory system of both rodents and macaque monkeys. In the cerebral cortex, neurons expressin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5da287661c6b7487cdeefea39e39637d
https://doi.org/10.1002/cne.23659
https://doi.org/10.1002/cne.23659
Autor:
Alex Thome, Katalin M. Gothard, James R. Engle, Theodore P. Trouard, Kojo Plange, Carol A. Barnes, Sara N. Burke
Publikováno v:
Journal of Neuroscience. 34:9905-9916
The orbitofrontal cortex (OFC) and amygdala are both necessary for decisions based on expected outcomes. Although behavioral and imaging data suggest that these brain regions are affected by advanced age, the extent to which aging alters appetitive p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acbb0f3e0b8ce034969c91c77d4dc463
https://doi.org/10.1523/jneurosci.3918-13.2014
https://doi.org/10.1523/jneurosci.3918-13.2014