Zobrazeno 1 - 10
of 137
pro vyhledávání: '"James R. Edwards"'
Autor:
Indong Jun, Haneul Choi, Hyeok Kim, Byoung Chan Choi, Hye Jung Chang, Youngjun Kim, Sung Woo Cho, James R. Edwards, Suk-Won Hwang, Yu-Chan Kim, Hyung-Seop Han, Hojeong Jeon
Publikováno v:
Bioactive Materials, Vol 43, Iss , Pp 181-194 (2025)
Medical stents are vital for treating vascular complications and restoring blood flow in millions of patients. Despite its widespread effectiveness, restenosis, driven by the complex interplay of cellular responses, remains a concern. This study inve
Externí odkaz:
https://doaj.org/article/c9281dee1c3d4917986a7658158b1304
Autor:
Daniele T. Cotton, Joseph A.E. Morgan, Alexander Feuerborn, James R. Edwards, Srinivasa R. Rao, Edmond J. Walsh, Claire M. Edwards
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100552- (2024)
Externí odkaz:
https://doaj.org/article/85d69e4057e440cc8f3cf4066b183903
Autor:
Seung-Hoon Um, Youngmin Seo, Hyunseon Seo, Kyungwoo Lee, Sun Hwa Park, Jung Ho Jeon, Jung Yeon Lim, Myoung-Ryul Ok, Yu-Chan Kim, Hyunjung Kim, Cheol-Hong Cheon, Hyung-Seop Han, James R. Edwards, Sung Won Kim, Hojeong Jeon
Publikováno v:
Biomaterials Research, Vol 26, Iss 1, Pp 1-15 (2022)
Abstract Background Cells in the human body experience different growth environments and conditions, such as compressive pressure and oxygen concentrations, depending on the type and location of the tissue. Thus, a culture device that emulates the en
Externí odkaz:
https://doaj.org/article/ba2a0d28bdda4f6fa7e2de9860a1517c
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-11 (2021)
Abstract Adiponectin is the most abundant circulating adipokine and is primarily involved in glucose metabolism and insulin resistance. Within the bone, osteoblasts and osteoclasts express the adiponectin receptors, however, there are conflicting rep
Externí odkaz:
https://doaj.org/article/470da4cf6d7540249dbdc633f9addf6b
Autor:
Beatriz Gámez, Emma V. Morris, Sam W.Z. Olechnowicz, Siobhan Webb, James R. Edwards, Aneka Sowman, Christina J. Turner, Claire M. Edwards
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101301- (2022)
Multiple myeloma is a haematological malignancy that is dependent upon interactions within the bone microenvironment to drive tumour growth and osteolytic bone disease. Metformin is an anti-diabetic drug that has attracted attention due to its direct
Externí odkaz:
https://doaj.org/article/8d405455344f4b739180c3e642c0eb66
Autor:
Sam W. Z. Olechnowicz, Megan M. Weivoda, Seint T. Lwin, Szi K. Leung, Sarah Gooding, Guido Nador, Muhammed Kassim Javaid, Karthik Ramasamy, Srinivasa R. Rao, James R. Edwards, Claire M. Edwards
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM are poorly understood. We have used in vivo murine models of MM to show significa
Externí odkaz:
https://doaj.org/article/d8afcd0e1a894dd9a3e3bba9c52aefc9
Autor:
Sarah Gooding, Sam W. Z. Olechnowicz, Emma V. Morris, Andrew E. Armitage, Joao Arezes, Joe Frost, Emmanouela Repapi, James R. Edwards, Neil Ashley, Craig Waugh, Nicola Gray, Erik Martinez-Hackert, Pei Jin Lim, Sant-Rayn Pasricha, Helen Knowles, Adam J. Mead, Karthik Ramasamy, Hal Drakesmith, Claire M. Edwards
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Multiple myeloma is a cancer of the bone marrow that can induce bone disease. Here, the authors profile the transcriptome of bone-lining cells and find a targetable role of bone morphogenetic protein (BMP) signalling in myeloma-induced bone-disease
Externí odkaz:
https://doaj.org/article/afce39d2e8774212826676e3142ffc40
Autor:
Jonathan H. Tobias, Emma L. Duncan, Erika Kague, Chrissy L. Hammond, Celia L. Gregson, Duncan Bassett, Graham R. Williams, Josine L. Min, Tom R. Gaunt, David Karasik, Claes Ohlsson, Fernando Rivadeneira, James R. Edwards, Fadil M. Hannan, John P. Kemp, Sophie J. Gilbert, Nerea Alonso, Neelam Hassan, Juliet E. Compston, Stuart H. Ralston
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
The discovery that sclerostin is the defective protein underlying the rare heritable bone mass disorder, sclerosteosis, ultimately led to development of anti-sclerostin antibodies as a new treatment for osteoporosis. In the era of large scale GWAS, m
Externí odkaz:
https://doaj.org/article/213a3053bba14147b16d8929aed76dac
Autor:
Hyung‐Seop Han, Indong Jun, Hyun‐Kwang Seok, Kang‐Sik Lee, Kyungwoo Lee, Frank Witte, Diego Mantovani, Yu‐Chan Kim, Sion Glyn‐Jones, James R. Edwards
Publikováno v:
Advanced Science, Vol 7, Iss 15, Pp n/a-n/a (2020)
Abstract Biodegradable metallic materials represent a potential step‐change technology that may revolutionize the treatment of broken bones. Implants made with biodegradable metals are significantly stronger than their polymer counterparts and full
Externí odkaz:
https://doaj.org/article/b100a8dec3cc4c5299b1a3de07567856
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 9, Pp 1-10 (2018)
Aging: toward a natural treatment for osteoarthritis The naturally occurring small molecule spermidine might prevent and repair the cartilage damage in osteoarthritis, commonly associated with aging. Spermidine was first found in semen but is widely
Externí odkaz:
https://doaj.org/article/208a02b5186a406eb9864c12d1294c70