Zobrazeno 1 - 10
of 37
pro vyhledávání: '"James R. Doroghazi"'
Autor:
Nabeel Imam, Ignacio Belda, Beatriz García-Jiménez, Adrian J. Duehl, James R. Doroghazi, Daniel E. Almonacid, Varghese P. Thomas, Alberto Acedo
Publikováno v:
mSphere, Vol 6, Iss 4 (2021)
Our results reinforce the notion that each cultivar on each location recruits a unique microbial community and that these communities are modulated by the vegetative growth stage of the plant. Moreover, inoculation of a Bacillus amyloliquefaciens
Externí odkaz:
https://doaj.org/article/bc00f4492cd1437ab8fc91f854f8799f
Autor:
Anthony W. Goering, Ryan A. McClure, James R. Doroghazi, Jessica C. Albright, Nicole A. Haverland, Yongbo Zhang, Kou-San Ju, Regan J. Thomson, William W. Metcalf, Neil L. Kelleher
Publikováno v:
ACS Central Science, Vol 2, Iss 2, Pp 99-108 (2016)
Externí odkaz:
https://doaj.org/article/deb6678d807b4d9ca6d6bdea3528e870
Autor:
Cheryl P. Andam, James R. Doroghazi, Ashley N. Campbell, Peter J. Kelly, Mallory J. Choudoir, Daniel H. Buckley
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT We show that Streptomyces biogeography in soils across North America is influenced by the regional diversification of microorganisms due to dispersal limitation and genetic drift. Streptomyces spp. form desiccation-resistant spores, which ca
Externí odkaz:
https://doaj.org/article/37284f349c344befb71633243212ebb4
Autor:
Adrian J. Duehl, Ignacio Belda, Beatriz García-Jiménez, Varghese P. Thomas, James R. Doroghazi, Daniel Almonacid, Alberto Acedo, Nabeel Imam
Publikováno v:
mSphere. Vol. 6, No. 4
mSphere, Vol 6, Iss 4 (2021)
mSphere
mSphere, Vol 6, Iss 4 (2021)
mSphere
Understanding the effectiveness and potential mechanism of action of agricultural biological products under different soil profiles and crops will allow more precise product recommendations based on local conditions and will ultimately result in incr
Autor:
Christian Krebs, James R. Doroghazi, Sara L. Milam, Deepa Balasubramanian, Joerg Freigang, Jelena Zaitseva, Daniel Vaknin, Nicholas B. Duck
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(8)
The crystal structure of the Gram-negative insecticidal protein, GNIP1Aa, has been solved at 2.5-Å resolution. The protein consists of two structurally distinct domains, a MACPF (membrane attack complex/PerForin) and a previously uncharacterized typ
Publikováno v:
Environmental Microbiology. 18:4931-4945
The biogeography of Streptomyces was examined at regional spatial scales to identify factors that govern patterns of microbial diversity. Streptomyces are spore forming filamentous bacteria which are widespread in soil. Streptomyces strains were isol
Autor:
William W. Metcalf, Ying Huang, David P. Labeda, Xiaoying Rong, Kou San Ju, James R. Doroghazi
Publikováno v:
International Journal of Systematic and Evolutionary Microbiology. 66:2444-2450
Previous phylogenetic analysis of species of the genus Streptomyces based on 16S rRNA gene sequences resulted in a statistically well-supported clade (100 % bootstrap value) containing eight species that exhibited very similar gross morphology in pro
Autor:
Nicole A. Haverland, Neil L. Kelleher, James R. Doroghazi, Kou San Ju, Anthony W. Goering, Jessica C. Albright, Yongbo Zhang, Ryan A. McClure, William W. Metcalf, Regan J. Thomson
Publikováno v:
ACS Central Science, Vol 2, Iss 2, Pp 99-108 (2016)
ACS Central Science
ACS Central Science
For more than half a century the pharmaceutical industry has sifted through natural products produced by microbes, uncovering new scaffolds and fashioning them into a broad range of vital drugs. We sought a strategy to reinvigorate the discovery of n
Autor:
Jeremy R. Hershfield, Seongjin Park, Tucker Maxson, Taekjip Ha, Nathan E. Schroeder, Kristen M. Flatt, Douglas A. Mitchell, Katie J. Molohon, Patricia M. Blair, James R. Doroghazi
Publikováno v:
ACS Infectious Diseases. 2:207-220
Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified natural product from Bacillus methylotrophicus FZB42 and Bacillus pumilus. Extensive tailoring to twelve of the fourteen amino acid residues in the mature natural prod
Autor:
Christopher J. Thibodeaux, Kwo Kwang A. Wang, Ryuichi Hirota, Joel P. Cioni, Joleen Su, Emily Metzger, Steven S. L. Li, Bradley S. Evans, Wilfred A. van der Donk, Jun Kai Zhang, Jiangtao Gao, Kou San Ju, David P. Labeda, William W. Metcalf, Jaeheon Lee, James R. Doroghazi, John Fudala
Publikováno v:
Proceedings of the National Academy of Sciences. 112:12175-12180
Although natural products have been a particularly rich source of human medicines, activity-based screening results in a very high rate of rediscovery of known molecules. Based on the large number of natural product biosynthetic genes in microbial ge