Ring Expansion Homologation: Synthetic Strategies and Reaction Design

Autor: James R. Donald, William P. Unsworth

Publikováno v: Homologation Reactions. :713-726

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b28815939fad335e706966275a86db7
https://doi.org/10.1002/9783527830237.ch19

Iridium‐Catalyzed Enantioselective Intermolecular Indole C2‐Allylation

Autor: Chao Zheng, William P. Unsworth, Richard J. K. Taylor, Aimee K. Clarke, Shu-Li You, James R. Donald, James A. Rossi-Ashton

Publikováno v: Angewandte Chemie (International Ed. in English)

The enantioselective intermolecular C2‐allylation of 3‐substituted indoles is reported for the first time. This directing group‐free approach relies on a chiral Ir‐(P, olefin) complex and Mg(ClO4)2 Lewis acid catalyst system to promote allyli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a78cc50f19e2f15619535a496ab3bed
https://doi.org/10.1002/anie.202001956

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy

Autor: Maria Chatzopoulou, Ben Edwards, Sarah E. Squire, Stephen G. Davies, Nicky J. Willis, Noelia Araujo Bazan, Daniel Conole, Francis Xavier Wilson, R. Fernando Martínez, Josh A. Milner, Angela J. Russell, N. Shah, Kay E. Davies, Graham Michael Wynne, Isabel V.L. Wilkinson, A Vuorinen, James R. Donald, R.J. Fairclough

Publikováno v: European journal of medicinal chemistry. 220

Duchenne muscular dystrophy is a fatal disease with no cure, caused by lack of the cytoskeletal protein dystrophin. Upregulation of utrophin, a dystrophin paralogue, offers a potential therapy independent of mutation type. The failure of first-in-cla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96309d85099c6a612dd4c9f48948a635
https://pubmed.ncbi.nlm.nih.gov/33915371

Visible-light-induced intramolecular charge transfer in the radical spirocyclisation of indole-tethered ynones

Autor: Peter O'Brien, Hon Eong Ho, Michael J. James, Ryan G. Epton, James R. Donald, James A. Rossi-Ashton, Angela Pagano, William P. Unsworth, Jonathan C. Churchill, Richard J. K. Taylor

Publikováno v: Chemical Science
Ho, H E, Pagano, A, Rossi-ashton, J A, Donald, J R, Epton, R G, Churchill, J C, James, M J, O'brien, P, Taylor, R J K & Unsworth, W P 2019, ' Visible-light-induced intramolecular charge transfer in the radical spirocyclisation of indole-tethered ynones ', Chemical Science, vol. 11, no. 5, pp. 1353-1360 . https://doi.org/10.1039/C9SC05311E

Indole-tethered ynones form an intramolecular electron donor–acceptor complex that can undergo visible-light-induced charge transfer to promote thiyl radical generation from thiols. This initiates a novel radical chain sequence, based on dearomatis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054e1d1028c891c2723beb56e6170668
https://eprints.whiterose.ac.uk/157506/1/c9sc05311e.pdf

Photoredox-Catalyzed Reductive Carbamoyl Radical Generation: A Redox-Neutral Intermolecular Addition–Cyclization Approach to Functionalized 3,4-Dihydroquinolin-2-ones

Autor: James R. Donald, Richard J. K. Taylor, Wade F. Petersen

Publikováno v: Organic Letters. 19:874-877

The first reductive generation of carbamoyl radicals using photoredox catalysis for their formation is reported. This approach facilitated the development of a redox-neutral synthesis of functionalized 3,4-dihydroquinolin-2-ones via the novel intermo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde5b1820565bdfdff89dee7d91adacd
https://doi.org/10.1021/acs.orglett.7b00022