Zobrazeno 1 - 10
of 244
pro vyhledávání: '"James R. Davie"'
Autor:
Chris-Tiann Roberts, Khatereh Saei Arezoumand, Ashraf Kadar Shahib, James R. Davie, Mojgan Rastegar
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Rare neurological diseases include a vast group of heterogenous syndromes with primary impairment(s) in the peripheral and/or central nervous systems. Such rare disorders may have overlapping phenotypes, despite their distinct genetic etiology. One u
Externí odkaz:
https://doaj.org/article/9b65840063194d9e8904ebbd1d768b7a
Autor:
Parisa Dashti, Eric A. Lewallen, Jonathan A.R. Gordon, Martin A. Montecino, Johannes P.T.M. van Leeuwen, Gary S. Stein, Bram C.J. van der Eerden, James R. Davie, Andre J. van Wijnen
Publikováno v:
Bone Reports, Vol 19, Iss , Pp 101704- (2023)
Osteogenic differentiation of mesenchymal cells is controlled by epigenetic enzymes that regulate post-translational modifications of histones. Compared to acetyl or methyltransferases, the physiological functions of protein arginine methyltransferas
Externí odkaz:
https://doaj.org/article/782923f9b7f54150befe4cda6e4e94a7
Autor:
Prasoon Agarwal, Brandy A. Wicklow, Allison B. Dart, Nikho A. Hizon, Elizabeth A.C. Sellers, Jonathan M. McGavock, Charlotte P. J. Talbot, Mario A. Fonseca, Wayne Xu, James R. Davie, Meaghan J. Jones, Animesh Acharjee, Vernon W. Dolinsky
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
ObjectiveRates of type 2 diabetes (T2D) among adolescents are on the rise. Epigenetic changes could be associated with the metabolic alterations in adolescents with T2D.MethodsWe performed a cross sectional integrated analysis of DNA methylation data
Externí odkaz:
https://doaj.org/article/ed82741761704a319291c6943fd6eae0
Autor:
Tasnim H. Beacon, James R. Davie
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8287 (2023)
The chicken genome is one-third the size of the human genome and has a similarity of sixty percent when it comes to gene content. Harboring similar genome sequences, chickens’ gene arrangement is closer to the human genomic organization than it is
Externí odkaz:
https://doaj.org/article/f28f289b0c4c497dafbfce545ebad44c
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15643 (2022)
Methyl CpG binding protein 2 (MeCP2) is an epigenetic reader that binds to methylated CpG dinucleotides and regulates gene transcription. Mecp2/MECP2 gene has 4 exons, encoding for protein isoforms MeCP2E1 and MeCP2E2. MeCP2 plays key roles in neurod
Externí odkaz:
https://doaj.org/article/4581e0d53b7f4bd6b6136ef1ee4e1f07
Publikováno v:
Cells, Vol 11, Iss 18, p 2830 (2022)
A subset of expressed genes is associated with a broad H3K4me3 (histone H3 trimethylated at lysine 4) domain that extends throughout the gene body. Genes marked in this way in normal cells are involved in cell-identity and tumor-suppressor activities
Externí odkaz:
https://doaj.org/article/d7625b9e31ab4725b4f8683e38ee7919
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-23 (2019)
Abstract Background Epigenetic (including DNA and histone) modifications occur in a variety of neurological disorders. If epigenetic features of brain autopsy material are to be studied, it is critical to understand the post-mortem stability of the m
Externí odkaz:
https://doaj.org/article/b8418571732642d4b96d900880d1f962
Autor:
Aleksandar Ilic, Sumin Lu, Vikram Bhatia, Farhana Begum, Thomas Klonisch, Prasoon Agarwal, Wayne Xu, James R. Davie
Publikováno v:
Epigenetics & Chromatin, Vol 10, Iss 1, Pp 1-16 (2017)
Abstract Background Ubiquitin C-terminal hydrolase isozyme L1 (UCHL1) is primarily expressed in neuronal cells and neuroendocrine cells and has been associated with various diseases, including many cancers. It is a multifunctional protein involved in
Externí odkaz:
https://doaj.org/article/51f8e7968c3647f89f206db1ab91b6d2
Autor:
Tasnim H. Beacon, James R. Davie
Publikováno v:
Cells, Vol 10, Iss 6, p 1354 (2021)
The chicken erythrocyte model system has been valuable to the study of chromatin structure and function, specifically for genes involved in oxygen transport and the innate immune response. Several seminal features of transcriptionally active chromati
Externí odkaz:
https://doaj.org/article/83d36ba3d284417fb6ea65bcc584612c
Autor:
Vichithra R. B. Liyanage, Jessica S. Jarmasz, Nanditha Murugeshan, Marc R. Del Bigio, Mojgan Rastegar, James R. Davie
Publikováno v:
Biology, Vol 3, Iss 4, Pp 670-723 (2014)
Epigenetics refers to a variety of processes that have heritable effects on gene expression programs without changes in DNA sequence. Key players in epigenetic control are chemical modifications to DNA, histone, and non-histone chromosomal proteins,
Externí odkaz:
https://doaj.org/article/f912d4666c46434ca808c1b797b5e8cb