Zobrazeno 1 - 10
of 25
pro vyhledávání: '"James R. Cypser"'
Publikováno v:
Cryobiology. 97:255
We report here a new, unbiased forward genetic method that uses transposon-mediated mutagenesis to enable the identification of mutations that confer cryoprotectant toxicity resistance (CTR). Our method is to select for resistance to the toxic effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eec0c3a94bbd93db4f9339fea94b3e9
https://doi.org/10.1016/j.cryobiol.2020.10.026
https://doi.org/10.1016/j.cryobiol.2020.10.026
Publikováno v:
Experimental Gerontology. 48:1014-1017
The nematode Caenorhabditis elegans continues to serve as a useful model of life extension caused by dietary restriction. Using this model, downstream effectors of dietary restriction-induced longevity have been elucidated, including neuropeptides an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b53395c92635059922e120d766e414
https://doi.org/10.1016/j.exger.2013.02.018
https://doi.org/10.1016/j.exger.2013.02.018
Autor:
Sang-Kyu Park, Alexander Mendenhall, Christopher D. Link, Thomas E. Johnson, Deqing Wu, Patricia M. Tedesco, Patrick C. Phillips, James R. Cypser
Publikováno v:
The Journals of Gerontology: Series A. :842-854
MULTICELLULAR organisms must respond to changes in the environment by altering their pattern of allocation of resources between growth (soma) and reproduction (germ line) in order to maximize lifetime reproductive fitness. These responses are mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262ee7468e427c2508d1f8fdbe9f4589
https://doi.org/10.1093/gerona/glr089
https://doi.org/10.1093/gerona/glr089
Autor:
Breanne L. Newell Stamper, Patricia M. Tedesco, David Kitzenberg, Thomas E. Johnson, James R. Cypser, Katerina Kechris
Publikováno v:
Aging Cell
Summary Research in aging biology has identified several pathways that are molecularly conserved across species that extend lifespan when mutated. The insulin/insulin‐like signaling (IIS) pathway is one of the most widely studied of these. It has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b36712d5883846215d8d06c378c584
https://doi.org/10.1111/acel.12704
https://doi.org/10.1111/acel.12704
Publikováno v:
Aging Cell. 8:666-675
Summary The analysis of age-specific mortality can yield insights into how anti-aging interventions operate that cannot be matched by simple assessment of longevity. Mortality, as opposed to longevity, can be used to assess the effects of an anti-agi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e678d0f1967bf80f0f5e9771b886e5f3
https://doi.org/10.1111/j.1474-9726.2009.00523.x
https://doi.org/10.1111/j.1474-9726.2009.00523.x
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 63:660-668
U-shaped dose-response relationships (hormesis) have been documented in numerous biological, toxicological, and pharmacological investigations. For example, in response to a mild 35 degrees C heat shock, the longevity of Caenorhabditis elegans exhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf76cbbd57936877cd972b55ae2bd8e3
https://doi.org/10.1093/gerona/63.7.660
https://doi.org/10.1093/gerona/63.7.660
Publikováno v:
Europe PubMed Central
Aging and a limited life span are fundamental biological realities. Recent studies have demonstrated that longevity can be manipulated and have revealed molecular mechanisms underlying longevity control in the soil nematode Caenorhabditis elegans. Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6858a6e921f06d4166bd009c1641299c
https://doi.org/10.1111/j.1749-6632.2000.tb06634.x
https://doi.org/10.1111/j.1749-6632.2000.tb06634.x
Publikováno v:
Nature Genetics. 36:1275-1281
Insulin-IGF receptor (InR) signaling has a conserved role in regulating lifespan, but little is known about the genetic control of declining organ function. Here, we describe progressive changes of heart function in aging fruit flies: from one to sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1012188d8df95f5457a5ca2ca0dd9417
https://doi.org/10.1038/ng1476
https://doi.org/10.1038/ng1476
Autor:
Thomas E. Johnson, James R. Cypser
Publikováno v:
Biogerontology. 4:203-214
We have shown that increased longevity and stress resistance can be induced by sub-lethal exposure to stressors (hormesis). Here we ask whether genes of the dauer formation pathway that are known to modulate life span in Caenorhabditis elegans are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f345a0fb4e31b187d5207e4cfabea5f
https://doi.org/10.1023/a:1025138800672
https://doi.org/10.1023/a:1025138800672
Autor:
Thomas E. Johnson, E. de Castro, Shin Murakami, Samuel T. Henderson, P. M. Tedesco, S. H. de Castro, James R. Cypser, Christopher D. Link, Brad A. Rikke
Publikováno v:
Journal of Inherited Metabolic Disease. 25:197-206
More than 40 single-gene mutants in Caenorhabditis elegans have been demonstrated to lead to increased lifespan (a rigorous, operational test for being a gerontogene) of 20% or more; these are referred to collectively as 'Age' mutants. Age mutants mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e8a83157d3509cfd8a4b6269c6ef42
https://doi.org/10.1023/a:1015677828407
https://doi.org/10.1023/a:1015677828407