Zobrazeno 1 - 10
of 87
pro vyhledávání: '"James R. Carlyle"'
Autor:
Raghd Al Olabi, Abd El Aziz Hendy, Mohamad Basem Alkassab, Karla Alnajm, Manahel Elias, Mary Ibrahim, James R. Carlyle, Andrew P. Makrigiannis, Mir Munir A Rahim
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTNatural killer (NK) cells are an important component of anti-cancer immunity, and their activity is regulated by an array of activating and inhibitory receptors. In mice, the inhibitory NKR-P1B receptor is expressed in NK cells and recognizes
Externí odkaz:
https://doaj.org/article/6acd1ed0413d4a638bc17330218a8f88
Autor:
Michal Scur, Ahmad Bakur Mahmoud, Sayanti Dey, Farah Abdalbarri, Iona Stylianides, Daniel Medina-Luna, Gayani S. Gamage, Aaron Woblistin, Alexa N. M. Wilson, Haggag S. Zein, Ashley Stueck, Andrew Wight, Oscar A. Aguilar, Francesca Di Cara, Brendon D. Parsons, Mir Munir A. Rahim, James R. Carlyle, Andrew P. Makrigiannis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Alveolar macrophages (AM) in the lungs maintain surfactant during homeostasis and respond to infectious pathogens. Here the authors show that in the absence of NKR-P1B, pneumococcal infection is more severe because KO AM have increased rates of lipid
Externí odkaz:
https://doaj.org/article/ca6a2921570140329609abd0d7a69abd
Autor:
Leslie Y. T. Leung, Srijit Khan, Patrick Budylowski, Zhijie Li, Sofiya Goroshko, Yanling Liu, Shilan Dong, James R. Carlyle, James M. Rini, Mario Ostrowski, Götz R. A. Ehrhardt
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
SARS-CoV-2 is a newly emerged betacoronavirus and the causative agent for the COVID-19 pandemic. Antibodies recognizing the viral spike protein are instrumental in natural and vaccine-induced immune responses to the pathogen and in clinical diagnosti
Externí odkaz:
https://doaj.org/article/b2a4e068165a428eb2240253c9e710f6
Autor:
Gautham R. Balaji, Oscar A. Aguilar, Miho Tanaka, Miguel A. Shingu-Vazquez, Zhihui Fu, Benjamin S. Gully, Lewis L. Lanier, James R. Carlyle, Jamie Rossjohn, Richard Berry
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Natural killer (NK) cells eliminate damaged cells, but spare healthy ones by recognizing their expressed ligands via NK inhibitory receptors. Here the authors solve the structure of an NK inhibitory receptor, NKR-P1B, bound to its ligand, Clr-b, with
Externí odkaz:
https://doaj.org/article/d0281b6f4ebc43a183d59a0c42bc49bc
Autor:
David S. J. Allan, Ana Sofia Cerdeira, Anuisa Ranjan, Christina L. Kirkham, Oscar A. Aguilar, Miho Tanaka, Richard W. Childs, Cynthia E. Dunbar, Jack L. Strominger, Hernan D. Kopcow, James R. Carlyle
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract For many years, human peripheral blood natural killer (NK) cells have been divided into functionally distinct CD3− CD56bright CD16− and CD3− CD56dim CD16+ subsets. Recently, several groups of innate lymphoid cells (ILC), distinct from
Externí odkaz:
https://doaj.org/article/fdd8503caef444f796bf5bf324863b3b
Autor:
James R. Carlyle, David S.J. Allan, Jason Moffat, Troy Ketela, Alberto Martin, Antoaneta Belcheva, Oscar A. Aguilar, Christina L. Kirkham, Jason H. Fine, Miho Tanaka
Natural killer (NK) cells express receptors specific for MHC class I (MHC-I) molecules involved in “missing-self” recognition of cancer and virus-infected cells. Here we elucidate the role of MHC-I-independent NKR-P1B:Clr-b interactions in the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b92bf1b96d9adc327ba5a83534a9231
https://doi.org/10.1158/0008-5472.c.6509745
https://doi.org/10.1158/0008-5472.c.6509745
Autor:
James R. Carlyle, David S.J. Allan, Jason Moffat, Troy Ketela, Alberto Martin, Antoaneta Belcheva, Oscar A. Aguilar, Christina L. Kirkham, Jason H. Fine, Miho Tanaka
Supplementary Methods describing intronic qRT-PCR, dual luciferase reporter assay, and CRISPR/Cas9 generation of ERK2-deficient cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5cbe37b17dd785fc72555b49acc700
https://doi.org/10.1158/0008-5472.22417125
https://doi.org/10.1158/0008-5472.22417125
Autor:
James R. Carlyle, David S.J. Allan, Jason Moffat, Troy Ketela, Alberto Martin, Antoaneta Belcheva, Oscar A. Aguilar, Christina L. Kirkham, Jason H. Fine, Miho Tanaka
Supplementary Tables S1 to S3 with captions. Table S1 shows PCR primers; Table S2 shows mutant vectors; Table S3 shows lymphoma phenotypes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a9223e4237327022c74c513b1fece0
https://doi.org/10.1158/0008-5472.22417122
https://doi.org/10.1158/0008-5472.22417122
Autor:
James R. Carlyle, David H. Raulet, Stephan Gasser, David S.J. Allan, Aruz Mesci, Peter Chen, Jason H. Fine
Supplementary Figure 2 from Chemotherapy-Induced Genotoxic Stress Promotes Sensitivity to Natural Killer Cell Cytotoxicity by Enabling Missing-Self Recognition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b349ed1f0017cd14c435eeaa11bb465
https://doi.org/10.1158/0008-5472.22382352
https://doi.org/10.1158/0008-5472.22382352
Autor:
James R. Carlyle, David H. Raulet, Stephan Gasser, David S.J. Allan, Aruz Mesci, Peter Chen, Jason H. Fine
Supplementary Figure Legends 1-3 from Chemotherapy-Induced Genotoxic Stress Promotes Sensitivity to Natural Killer Cell Cytotoxicity by Enabling Missing-Self Recognition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0ab970c0cb326510a7f166d41849bb
https://doi.org/10.1158/0008-5472.22382346
https://doi.org/10.1158/0008-5472.22382346