Zobrazeno 1 - 10
of 253
pro vyhledávání: '"James R. Broach"'
Autor:
Tarik J. Salameh, Katharine Roth, Lisa Schultz, Zhexi Ma, Anthony S. Bonavia, James R. Broach, Bin Hu, Judie A. Howrylak
Publikováno v:
Gut Pathogens, Vol 15, Iss 1, Pp 1-9 (2023)
Abstract Background Critical illness and care within the intensive care unit (ICU) leads to profound changes in the composition of the gut microbiome. The impact of such changes on the patients and their subsequent disease course remains uncertain. W
Externí odkaz:
https://doaj.org/article/66a6023eae2f426083de82baf815242e
Autor:
Ane Catarine Tosi Costa, Lisa Schneper, Mariano Russo, A. Alberto R. Fernandes, James R. Broach, Patricia M. B. Fernandes
Publikováno v:
Fermentation, Vol 10, Iss 8, p 395 (2024)
While the transcriptional responses of yeast cells to a variety of individual stress conditions have been extensively studied, their responses to sequential stress conditions are less well understood. In this study, we present a comparative analysis
Externí odkaz:
https://doaj.org/article/0cb753542c8346498e01ab34f4321b2e
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3785 (2024)
The genetic contributions of Neanderthals to the modern human genome have been evidenced by the comparison of present-day human genomes with paleogenomes. Neanderthal signatures in extant human genomes are attributed to intercrosses between Neanderth
Externí odkaz:
https://doaj.org/article/cfbf2610f7944c579bda886f0e202dac
Autor:
Mercedeh Movassagh, Sarah U. Morton, Christine Hehnly, Jasmine Smith, Trang T. Doan, Rafael Irizarry, James R. Broach, Steven J. Schiff, Jeffrey A. Bailey, Joseph N. Paulson
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract We introduce mirTarRnaSeq, an R/Bioconductor package for quantitative assessment of miRNA-mRNA relationships within sample cohorts. mirTarRnaSeq is a statistical package to explore predicted or pre-hypothesized miRNA-mRNA relationships follo
Externí odkaz:
https://doaj.org/article/4ba6b9cc99ba479eb7c74c737024ba74
Autor:
Christine Hehnly, Paddy Ssentongo, Lisa M. Bebell, Kathy Burgoine, Joel Bazira, Claudio Fronterre, Elias Kumbakumba, Ronald Mulondo, Edith Mbabazi-Kabachelor, Sarah U. Morton, Joseph Ngonzi, Moses Ochora, Peter Olupot-Olupot, John Mugamba, Justin Onen, Drucilla J. Roberts, Kathryn Sheldon, Shamim A. Sinnar, Jasmine Smith, Peter Ssenyonga, Julius Kiwanuka, Joseph N. Paulson, Frederick A. Meier, Jessica E. Ericson, James R. Broach, Steven J. Schiff
Publikováno v:
International Journal of Infectious Diseases, Vol 118, Iss , Pp 24-33 (2022)
Objectives: To estimate the prevalence of cytomegalovirus (CMV) infections among newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus in Uganda. Design and Methods: Three populations—newborn-mother pairs, neonates with sepsis,
Externí odkaz:
https://doaj.org/article/08c5c98caae347578706910934f0ef61
Autor:
Christine Hehnly, Aiqin Shi, Paddy Ssentongo, Lijun Zhang, Albert Isaacs, Sarah U. Morton, Nicholas Streck, Petra Erdmann-Gilmore, Igor Tolstoy, R. Reid Townsend, David D. Limbrick, Joseph N. Paulson, Jessica E. Ericson, Michael Y. Galperin, Steven J. Schiff, James R. Broach
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Hydrocephalus, the leading indication for childhood neurosurgery worldwide, is particularly prevalent in low- and middle-income countries. Hydrocephalus preceded by an infection, or postinfectious hydrocephalus, accounts for up to 60% of hyd
Externí odkaz:
https://doaj.org/article/4ed3d517da8341ba9e490b66a1529316
Autor:
Mercedeh Movassagh, Lisa M. Bebell, Kathy Burgoine, Christine Hehnly, Lijun Zhang, Kim Moran, Kathryn Sheldon, Shamim A. Sinnar, Edith Mbabazi-Kabachelor, Elias Kumbakumba, Joel Bazira, Moses Ochora, Ronnie Mulondo, Brian Kaaya Nsubuga, Andrew D. Weeks, Melissa Gladstone, Peter Olupot-Olupot, Joseph Ngonzi, Drucilla J. Roberts, Frederick A. Meier, Rafael A. Irizarry, James R. Broach, Steven J. Schiff, Joseph N. Paulson
Publikováno v:
npj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract The composition of the maternal vaginal microbiome influences the duration of pregnancy, onset of labor, and even neonatal outcomes. Maternal microbiome research in sub-Saharan Africa has focused on non-pregnant and postpartum composition of
Externí odkaz:
https://doaj.org/article/aec5a945eb0b423e9ee84dede5fe278d
Autor:
Ane Catarine Tosi Costa, Mariano Russo, A. Alberto R. Fernandes, James R. Broach, Patricia M. B. Fernandes
Publikováno v:
Fermentation, Vol 9, Iss 2, p 195 (2023)
During the fermentation process, yeast cells face different stresses, and their survival and fermentation efficiency depend on their adaptation to these challenging conditions. Yeast cells must tolerate not only a single stress but also multiple simu
Externí odkaz:
https://doaj.org/article/f73a7da5f0bb4cdcb9d41f35c605e4e9
Autor:
Jonathan Li, Ryan G. Lim, Julia A. Kaye, Victoria Dardov, Alyssa N. Coyne, Jie Wu, Pamela Milani, Andrew Cheng, Terri G. Thompson, Loren Ornelas, Aaron Frank, Miriam Adam, Maria G. Banuelos, Malcolm Casale, Veerle Cox, Renan Escalante-Chong, J. Gavin Daigle, Emilda Gomez, Lindsey Hayes, Ronald Holewenski, Susan Lei, Alex Lenail, Leandro Lima, Berhan Mandefro, Andrea Matlock, Lindsay Panther, Natasha Leanna Patel-Murray, Jacqueline Pham, Divya Ramamoorthy, Karen Sachs, Brandon Shelley, Jennifer Stocksdale, Hannah Trost, Mark Wilhelm, Vidya Venkatraman, Brook T. Wassie, Stacia Wyman, Stephanie Yang, Jennifer E. Van Eyk, Thomas E. Lloyd, Steven Finkbeiner, Ernest Fraenkel, Jeffrey D. Rothstein, Dhruv Sareen, Clive N. Svendsen, Leslie M. Thompson, Hemali Phatnani, PhD, Justin Kwan, MD, Dhruv Sareen, PhD, James R. Broach, PhD, Zachary Simmons, MD, Ximena Arcila-Londono, MD, Edward B. Lee, MD, PhD, Vivianna M. Van Deerlin, MD, PhD, Neil A. Shneider, MD, PhD, Ernest Fraenkel, PhD, Lyle W. Ostrow, MD, PhD, Frank Baas, MD, PhD, Noah Zaitlen, PhD, James D. Berry, MD, MPH, Andrea Malaspina, MD, PhD, Pietro Fratta, MD, PhD, Gregory A. Cox, PhD, Leslie M. Thompson, PhD, Steve Finkbeiner, MD, PhD, Efthimios Dardiotis, MD, PhD, Timothy M. Miller, MD, PhD, Siddharthan Chandran, PhD, Suvankar Pal, MD, Eran Hornstein, MD, PhD, Daniel J. MacGowan, MD, Terry Heiman-Patterson, MD, Molly G. Hammell, PhD, Nikolaos.A. Patsopoulos, MD, PhD, Oleg Butovsky, PhD, Joshua Dubnau, PhD, Avindra Nath, MD, Robert Bowser, PhD, Matt Harms, MD, Mary Poss, DVM, PhD, Jennifer Phillips-Cremins, PhD, John Crary, MD, PhD, Nazem Atassi, MD, Dale J. Lange, MD, Darius J. Adams, MD, Leonidas Stefanis, MD, PhD, Marc Gotkine, MD, Robert H. Baloh, MD. PhD, Suma Babu, MBBS, MPH, Towfique Raj, PhD, Sabrina Paganoni, MD, PhD, Ophir Shalem, PhD, Colin Smith, MD, Bin Zhang, PhD, Brent Harris, MD, PhD, Iris Broce, PhD, Vivian Drory, MD, John Ravits, MD, Corey McMillan, PhD, Vilas Menon, PhD, Lani Wu, PhD, Steven Altschuler, PhD
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103221- (2021)
Summary: Neurodegenerative diseases are challenging for systems biology because of the lack of reliable animal models or patient samples at early disease stages. Induced pluripotent stem cells (iPSCs) could address these challenges. We investigated D
Externí odkaz:
https://doaj.org/article/b0aa201abf104ba08a6430dac01837c5
Autor:
Albert M. Isaacs, Sarah U. Morton, Mercedeh Movassagh, Qiang Zhang, Christine Hehnly, Lijun Zhang, Diego M. Morales, Shamim A. Sinnar, Jessica E. Ericson, Edith Mbabazi-Kabachelor, Peter Ssenyonga, Justin Onen, Ronnie Mulondo, Mady Hornig, Benjamin C. Warf, James R. Broach, R. Reid Townsend, David D. Limbrick, Jr., Joseph N. Paulson, Steven J. Schiff
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102351- (2021)
Summary: Inflammation during neonatal brain infections leads to significant secondary sequelae such as hydrocephalus, which often follows neonatal sepsis in the developing world. In 100 African hydrocephalic infants we identified the biological pathw
Externí odkaz:
https://doaj.org/article/fe91a2ee504742a49bd7a725309d337a