Výsledky vyhledávání - "James R. Black"

Akademický článek

Programmed cell death ligands expression in phaeochromocytomas and paragangliomas: Relationship with the hypoxic response, immune evasion and malignant behavior

Autor: David J. Pinato, James R. Black, Sebastian Trousil, Roberto E. Dina, Pritesh Trivedi, Francesco A. Mauri, Rohini Sharma

Publikováno v: OncoImmunology, Vol 6, Iss 11 (2017)

The hypoxic response underlies the pathogenesis and malignant behavior of PCC/PGL. Regulation of PD-1 receptor-ligand signaling, a therapeutically actionable driver of the anti-tumor immune response, is a hypoxic-driven trait across malignancies. We

Externí odkaz: https://doaj.org/article/90c7d2b2fe324049b3935be835fe949d

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Abstract 1394: Pervasive allele specific transcriptional repression of the class I and II HLA genes in TRACERx non-small cell lung cancer

Publikováno v: Cancer Research. 82:1394-1394

Background: The adaptive immune system plays an important role in tumor evolution. A key source of cytotoxic T cell response in cancer is neoantigens, cancer cell specific mutations that result in mutant peptides that elicit a T cell mediated immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25c78766a1a24dafd3be2ba990e6fab9
https://doi.org/10.1158/1538-7445.am2022-1394

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Synthesis and biological evaluation of nitric oxide-donating analogues of sulindac for prostate cancer treatment

Autor: David O'Hagan, James R. Black, Andrew Nortcliffe, Alexander G. Ekstrom, Nigel P. Botting, James A. Ross, Fouad K. Habib

Publikováno v: Bioorganic & Medicinal Chemistry. 22:756-761

A series of analogues of the non-steroidal anti-inflammatory drug (NSAID) sulindac 1 were synthesised tethered to nitric oxide (NO) donating functional groups. Sulindac shows antiproliterative effects against immortal PC3 cell lines. It was previousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855d91c3b165a79946c164da1ad05298
https://doi.org/10.1016/j.bmc.2013.12.014

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Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism

Autor: Zara Hannoun, Claire N. Medine, Sebastian Greenhough, John P. Iredale, Salvatore Pernagallo, Mark Bradley, James A. Ross, Judy Fletcher, James R. Black, Alexandra I. Thompson, Juan J. Díaz-Mochón, Donna Dalgetty, Joerg Schrader, Stuart J. Forbes, David C. Hay, Philip N. Newsome

Publikováno v: Stem Cell Research. 6(2):92-102

Maintaining stable differentiated somatic cell function in culture is essential to a range of biological endeavors. However, current technologies, employing, for example, primary hepatic cell culture (essential to the development of a bio-artificial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9017e6c999f57faa2ba90afcc1f70b

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The Inhibitory Role of Stromal Cell Mesenchyme on Human Embryonic Stem Cell Hepatocyte Differentiation is Overcome by Wnt3a Treatment

Autor: James R. Black, James A. Ross, Catherine Payne, Ian Currie, John P. Iredale, Wei Cui, Kay Samuel, John D. Terrace, David C. Hay, Philip N. Newsome, Stuart J. Forbes, Judy Fletcher, Celine Filippi, Zara Hannoun

Publikováno v: Cloning and Stem Cells. 10:331-340

Pluripotent stem cells are derived from the inner cell mass of preimplantation embryos, and display the ability of the embryonic founder cells by forming all three germ lineages in vitro. It is well established that the cellular niche plays an import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19b3c7e2584b0c727355602acf7ab25
https://doi.org/10.1089/clo.2007.0094

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Efficient Differentiation of Hepatocytes from Human Embryonic Stem Cells Exhibiting Markers Recapitulating Liver Development In Vivo

Autor: James A. Ross, Cliff Elcombe, Debiao Zhao, Judy Fletcher, Doris McLean, Zoe Hewitt, Alai Urruticoechea-Uriguen, David C. Hay, James R. Black, Wei Cui, Roland Wolf

Publikováno v: Stem Cells. 26:894-902

The potential to differentiate human embryonic stem cells (hESCs) in vitro to provide an unlimited source of human hepatocytes for use in biomedical research, drug discovery, and the treatment of liver diseases holds great promise. Here we describe a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d85500914ff3c17bff64007087b44b
https://doi.org/10.1634/stemcells.2007-0718

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Efficient episomal reprogramming of blood mononuclear cells and differentiation to hepatocytes with functional drug metabolism

Autor: Joanna Brzeszczynska, Anwar Azad Palakkan, R. C. J. Gallagher, Richard A. Anderson, James R. Black, James A. Ross, Jing Liu, Kay Samuel

Publikováno v: Experimental cell research. 338(2)

The possibility of converting cells from blood mononuclear cells (MNC) to liver cells provides promising opportunities for the study of diseases and the assessment of new drugs. However, clinical applications have to meet GMP requirements and the met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c44c364d89e04c468669ff6615c46b
https://pubmed.ncbi.nlm.nih.gov/26256888

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Immune Alterations, Lipid Peroxidation, and Muscle Damage Following a Hill Race

Autor: Greg Whyte, Geraint Florida-James, Keith Guy, Richard J. Simpson, Martin Wilson, James A. Ross, James R. Black

Publikováno v: Canadian Journal of Applied Physiology. 30:196-211

Hill races usually include large downhill running sections, which can induce significant degrees of muscle damage in a field setting. This study examined the link between muscle damage, oxidative stress, and immune perturbations following a 7-km moun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff03e64973c3895741e9cd7a049835f5
https://doi.org/10.1139/h05-115

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Preliminary Analysis of Multiple Crystal Forms of the Bovine Cyclophilin-Cyclosporin A Complex

Autor: Matthew J. Fitzgibbon, James R. Black, Susumu Itoh, Manuel A. Navia

Publikováno v: Journal of Molecular Biology. 235:1136-1140

The immunosuppressant cyclosporin-Δ (CsA) has been crystallized in complex with the bovine form of its major receptor protein cyclophilin (CyP) in three different forms by the hanging-drop vapor diffusion method. A hexagonal crystal form (P6 1 22 or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d6773b4147e2ffd6786cda6af61d91
https://doi.org/10.1006/jmbi.1994.1062

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Differential production of gamma delta T cells in the urine of bladder cancer patients receiving Bacillus Calmette Guerin immunotherapy

Autor: Anton B. Alexandroff, Presad Ramachandra Bollina, Keith James, James R. Black

Publikováno v: International journal of oncology. 10(2)

Bacillus Calmette Guerin (BCG) intravesical therapy of bladder cancer is arguably the most effective immunotherapy for any human solid tumour. It combines a high incidence of remission induction with a low level of side effects and a low rate of recu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55e191d6210d2ffd7c26b1c4eecae95
https://pubmed.ncbi.nlm.nih.gov/21533389

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