Zobrazeno 1 - 10
of 34
pro vyhledávání: '"James R. Birtley"'
Autor:
Mario Meza-Segura, James R. Birtley, Ana Maldonado-Contreras, Christian Mueller, Karl J. Simin, Lawrence J. Stern, Beth A. McCormick
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Shigella spp. are highly adapted pathogens that cause bacillary dysentery in human and nonhuman primates. An unusual feature of Shigella pathogenesis is that this organism invades the colonic epithelia from the basolateral pole. Therefore, i
Externí odkaz:
https://doaj.org/article/bd3df0bb0d904501a8a19ef1ce7a986c
Autor:
Wei Jiang, James R. Birtley, Shu-Chen Hung, Weiqi Wang, Shin-Heng Chiou, Claudia Macaubas, Birgitte Kornum, Lu Tian, Huang Huang, Lital Adler, Grant Weaver, Liying Lu, Alexandra Ilstad-Minnihan, Sriram Somasundaram, Sashi Ayyangar, Mark M. Davis, Lawrence J. Stern, Elizabeth D. Mellins
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
T cells from narcolepsy patients were recently reported to recognize hypocretin, a wakefulness-promoting neurohormone, suggesting autoimmune origin of the disease. Here the authors show that hypocretin-specific T cells expand both in healthy controls
Externí odkaz:
https://doaj.org/article/c167c2cc9a574287872bf608f7e73845
Autor:
James R. Birtley, Mohammad Alomary, Elisa Zanini, Jane Antony, Zachary Maben, Grant C. Weaver, Claudia Von Arx, Manuela Mura, Aline T. Marinho, Haonan Lu, Eloise V. N. Morecroft, Evdoxia Karali, Naomi E. Chayen, Edward W. Tate, Mollie Jurewicz, Lawrence J. Stern, Chiara Recchi, Hani Gabra
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
OPCML is a tumour suppressor gene that is epigenetically silenced in ovarian cancer and is somatically mutated in various cancers. Here, the authors solve the X-ray crystal structure of OPCML and model clinically relevant mutations that could contrib
Externí odkaz:
https://doaj.org/article/0d39746c3dc44914b53cf2c2f0ee8062
Autor:
Wei Jiang, James R. Birtley, Shu-Chen Hung, Weiqi Wang, Shin-Heng Chiou, Claudia Macaubas, Birgitte Kornum, Lu Tian, Huang Huang, Lital Adler, Grant Weaver, Liying Lu, Alexandra Ilstad-Minnihan, Sriram Somasundaram, Sashi Ayyangar, Mark M. Davis, Lawrence J. Stern, Elizabeth D. Mellins
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/96aacd3a26fb4821be774590097d0eaa
Autor:
Alex Macpherson, Maisem Laabei, Zainab Ahdash, Melissa A Graewert, James R Birtley, Monika-Sarah ED Schulze, Susan Crennell, Sarah A Robinson, Ben Holmes, Vladas Oleinikovas, Per H Nilsson, James Snowden, Victoria Ellis, Tom Eirik Mollnes, Charlotte M Deane, Dmitri Svergun, Alastair DG Lawson, Jean MH van den Elsen
Publikováno v:
eLife, Vol 10 (2021)
Bovines have evolved a subset of antibodies with ultra-long heavy chain complementarity determining regions that harbour cysteine-rich knob domains. To produce high-affinity peptides, we previously isolated autonomous 3–6 kDa knob domains from bovi
Externí odkaz:
https://doaj.org/article/11009d4406c0451a844e90851ac87e3f
Autor:
James R. Birtley, Beth A. McCormick, Lawrence J. Stern, Christian Mueller, Karl J. Simin, Mario Meza-Segura, Ana Maldonado-Contreras
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
Shigella spp. are highly adapted pathogens that cause bacillary dysentery in human and nonhuman primates. An unusual feature of Shigella pathogenesis is that this organism invades the colonic epithelia from the basolateral pole. Therefore, it has evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9164c2f0d7ed2583a6266bbf2dd732
https://doi.org/10.1128/mbio.02833-21
https://doi.org/10.1128/mbio.02833-21
Autor:
Mario, Meza-Segura, James R, Birtley, Ana, Maldonado-Contreras, Christian, Mueller, Karl J, Simin, Lawrence J, Stern, Beth A, McCormick
Publikováno v:
mBio
Shigella spp. are highly adapted pathogens that cause bacillary dysentery in human and nonhuman primates. An unusual feature of Shigella pathogenesis is that this organism invades the colonic epithelia from the basolateral pole. Therefore, it has evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8906db2003b6a7dc72750a185a797e73
https://pubmed.ncbi.nlm.nih.gov/34724811
https://pubmed.ncbi.nlm.nih.gov/34724811
Autor:
Yalan Tang, Jean M. H. van den Elsen, Phil Stanley, Maisem Laabei, Toska Wonfor, Callum Joyce, Richard D. Taylor, Kenneth Saunders, Robert J. Broadbridge, Alastair D. G. Lawson, Sebastian Kelm, Gregory Bogle, Matthew Duncan Selby, Douangsone Vadysirisack, Alex Macpherson, Kevin Brady, Jiye Shi, Richard J. Franklin, James R. Birtley, John Horton, Adam Hold, Monika-Sarah E. D. Schulze
Cysteine-rich knob domains found in the ultralong complementarity determining regions of a subset of bovine antibodies, are capable of functioning autonomously as 3-6 kDa peptides. While they can be expressed recombinantly in cellular systems, in thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979d9fb522645065a68d3d469815cd27
https://doi.org/10.1101/2021.06.16.448769
https://doi.org/10.1101/2021.06.16.448769
Autor:
Haonan Lu, Mohammad N. Alomary, Hani Gabra, Chiara Recchi, Evdoxia Karali, Edward W. Tate, Naomi E. Chayen, Manuela Mura, Zachary Maben, Grant C. Weaver, Aline T. Marinho, Mollie Jurewicz, James R. Birtley, Eloise V. N. Morecroft, Lawrence J. Stern, Jane Antony, Claudia von Arx, Elisa Zanini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
OPCML, a tumor suppressor gene, is frequently silenced epigenetically in ovarian and other cancers. Here we report, by analysis of databases of tumor sequences, the observation of OPCML somatic missense mutations from various tumor types and the impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cfed575691e5c93eb9b8a3de4d31e0
http://link.springer.com/article/10.1038/s41467-019-10966-8
http://link.springer.com/article/10.1038/s41467-019-10966-8
Autor:
Monika-Sarah E. D. Schulze, Susan J. Crennell, Charlotte M. Deane, Maisem Laabei, Zainab Ahdash, Melissa A. Graewert, Per H. Nilsson, Victoria Ellis, Alex Macpherson, Sarah Robinson, Dmitri I. Svergun, Ben Holmes, James R. Birtley, Alastair D. G. Lawson, James Snowden, Vladas Oleinikovas, Jean M. H. van den Elsen, Tom Eirik Mollnes
Publikováno v:
eLIFE
eLife 10, e63586 (1-27) (2021). doi:10.7554/eLife.63586
eLife
eLife, Vol 10 (2021)
eLife 10, e63586 (1-27) (2021). doi:10.7554/eLife.63586
eLife
eLife, Vol 10 (2021)
eLife 10, e63586 (1-27) (2021). doi:10.7554/eLife.63586
Bovines have evolved a subset of antibodies with ultra-long heavy chain complementarity determining regions that harbour cysteine-rich knob domains. To produce high-affinity peptides, we pr
Bovines have evolved a subset of antibodies with ultra-long heavy chain complementarity determining regions that harbour cysteine-rich knob domains. To produce high-affinity peptides, we pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eed3917dfffc6eadc264d57a89b550f
https://hdl.handle.net/11250/2778550
https://hdl.handle.net/11250/2778550