Zobrazeno 1 - 10
of 62
pro vyhledávání: '"James R. Bartles"'
Publikováno v:
Cytoskeleton (Hoboken, N.J.). 79(6-8)
Stereocilia are actin-based projections of hair cells that are arranged in a step like array, in rows of increasing height, and that constitute the mechanosensory organelle used for the senses of hearing and balance. In order to function properly, st
Autor:
Saima Riazuddin, Khitab Gul, Robert A. Sisk, Sheikh Riazuddin, Lili Zheng, Gowri N. Sarangdhar, Thomas Jaworek, Shaheen N. Khan, James R. Bartles, Zubair M. Ahmed, Thomas B. Friedman
Publikováno v:
Journal of Medical Genetics. 55:479-488
BackgroundUsher syndrome (USH) is a neurosensory disorder characterised by deafness, variable vestibular areflexia and vision loss. The aim of the study was to identify the genetic defect in a Pakistani family (PKDF1051) segregating USH.MethodsGenome
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1002032 (2011)
Hearing and vestibular function depend on mechanosensory staircase collections of hair cell stereocilia, which are produced from microvillus-like precursors as their parallel actin bundle scaffolds increase in diameter and elongate or shorten. Hair c
Externí odkaz:
https://doaj.org/article/50ff00f1315042dd8ca20126ab1613a9
Autor:
Zubair M, Ahmed, Thomas J, Jaworek, Gowri N, Sarangdhar, Lili, Zheng, Khitab, Gul, Shaheen N, Khan, Thomas B, Friedman, Robert A, Sisk, James R, Bartles, Sheikh, Riazuddin, Saima, Riazuddin
Publikováno v:
Journal of medical genetics. 55(7)
BACKGROUND: Usher syndrome (USH) is a neurosensory disorder characterised by deafness, variable vestibular areflexia and vision loss. The aim of the study was to identify the genetic defect in a Pakistani family (PKDF1051) segregating USH. METHODS: G
Autor:
Gregory A. Voth, Jenna R. Christensen, Alyssa J Harker, Glen M. Hocky, Cristian Suarez, James R. Bartles, Jonathan D. Winkelman, David R. Kovar, Alisha N Morganthaler
Publikováno v:
Current biology : CB. 26(20)
Cells assemble and maintain functionally distinct actin cytoskeleton networks with various actin filament organizations and dynamics through the coordinated action of different sets of actin-binding proteins. The biochemical and functional properties
Autor:
Andrew J. Griffith, John A. Hammer, Ruben Stepanyan, Gregory I. Frolenkov, Thomas B. Friedman, Guy P. Richardson, Jenny E. Hinshaw, Ikuko Fujiwara, Shin-ichiro Kitajiri, James R. Bartles, Zubair M. Ahmed, Sheikh Riazuddin, James R. Sellers, Jonathan E. Bird, Richard J. Goodyear, Saima Riazuddin, Inna A. Belyantseva, Takeshi Sakamoto
Publikováno v:
Cell. 141:786-798
Inner ear hair cells detect sound through deflection of mechanosensory stereocilia. Each stereocilium is supported by a paracrystalline array of parallel actin filaments that are packed more densely at the base, forming a rootlet extending into the c
Publikováno v:
The Journal of Comparative Neurology. 509:661-676
The espins are Ca(2+)-resistant actin-bundling proteins that are enriched in hair cell stereocilia and sensory cell microvilli. Here, we report a novel localization of espins to a large proportion of rat type I spiral ganglion neurons (SGNs) and thei
Autor:
Keiichi Nagata, Andrew J. Castiglioni, Jaime García-Añoveros, Thomas Madathany, Lili Zheng, James R. Bartles
Publikováno v:
Proceedings of the National Academy of Sciences. 105:353-358
Varitint-waddler (Va and Va J ) mice are deaf and have vestibular impairment, with inner ear defects that include the degeneration and loss of sensory hair cells. The semidominant Va mutation results in an alanine-to-proline substitution at residue 4
Autor:
James R. Bartles, Charles E. Smith, Daniel G. Cyr, Julie Dufresne, Nadia Primiani, Ye Lauren Liu, Louis Hermo, Mary Gregory
Publikováno v:
Journal of Andrology. 28:659-669
Principal cells of the epididymis are the most prominent cell type and are noted for an apical cell surface studded with microvilli. The latter contain channel proteins that condition the microenvironment of epididymal lumen and promote sperm maturat
Publikováno v:
Cellular and Molecular Life Sciences. 63:2329-2341
The espins are novel actin-bundling proteins that are produced in multiple isoforms from a single gene. They are present at high concentration in the parallel actin bundle of hair cell stereocilia and are the target of deafness mutations in mice and