Zobrazeno 1 - 10
of 166
pro vyhledávání: '"James R. McCarthy"'
Autor:
Prasad S. Sunkara, James R. McCarthy
Publikováno v:
CHEMICAL and STRUCTURAL APPROACHES to RATIONAL DRUG DESIGN ISBN: 9781003068808
CHEMICAL and STRUCTURAL APPROACHES to RATIONAL DRUG DESIGN
CHEMICAL and STRUCTURAL APPROACHES to RATIONAL DRUG DESIGN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c858176a515ba0d02bfa6be84afaf83c
https://doi.org/10.1201/9781003068808-2
https://doi.org/10.1201/9781003068808-2
Autor:
Laura Harmon, Tovah Z Moss, John P. Sharpe, James R. Mccarthy, M. Bala, Deborah M. Stein, Darren J Hunt, Eric A. Toschlog, Rachael A. Callcut, Martin D. Zielinski, Cassandra Reynolds, Kimberly A. Peck, Joseph M. Galante, James M. Haan, Allison E. Berndtson, Mitchell J. Cohen, Ajai K Malhotra, Stephanie A. Savage, Vincent Anto, Bryan R. Collier, Daniel C. Cullinane, Charles D Behnfield, Todd Neideen, Steve Gondek, Peter Rhee, Aaron M. Williams, Narong Kulvatunyou, Steve Moulton, Scott A. John, Kimberly Linden, Mohamed D. Ray-Zack, Pascal Udekwu, Savo Bou Zein Eddine, Casey E. Dunne, Bryan C. Morse, Ben L. Zarzaur, Edmund J. Rutherford, Brian Coates, S. Rob Todd, Faran Bokhari, Jennie Kim, Young Mee Choi, Joshua P. Hazelton, M Chance Spalding, Tejveer S. Dhillon, Kenji Inaba, Kelly L. Lightwine, Ahmed F Khouqeer, Martin A. Croce, Julie Dunn, Hasan B Alam, Christine J. Waller, Kara J. Kallies, Amanda Celii, Joshua J. Sumislawski, Raul Coimbra, Michael West, Kristina Kramer, Clay Cothren Burlew, Tyler L Zander, Jacob P Veith, Jennifer L. Hartwell, J Sperry, Paul R Beery, Harry L Warren, Michelle K McNutt, Chad G. Ball, Christopher A. Wybourn, Jeffry L. Kashuk, Tammy Ju, Carlos Vr Brown
Publikováno v:
Journal of Trauma and Acute Care Surgery. 85:858-866
Screening for blunt cerebrovascular injuries (BCVIs) in asymptomatic high-risk patients has become routine. To date, the length of this asymptomatic period has not been defined. Determining the time to stroke could impact therapy including earlier in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6a8f8c2a7562d67e8818469949ab33
https://doi.org/10.1097/ta.0000000000001989
https://doi.org/10.1097/ta.0000000000001989
Autor:
José Francisco Soriano, Javier Agejas, Rosario Gonzalez, Ramón Rodríguez, Timothy B. Durham, Howard Barff Broughton, Juan F. Espinosa, Paloma Vidal, Ana B. Bueno, Robert Dean Dally, Hsiu-Chiung Yang, Alicia Marcos, David E. Timm, Gema Sanz, James R. McCarthy, Patric James Hahn
Publikováno v:
Journal of Medicinal Chemistry. 60:9807-9820
NMR conformational analysis of a hydroxyethylamine peptide isostere developed as an aspartic protease inhibitor shows that it is a flexible architecture. Cyclization to form pyrrolidines, piperidines, or morpholines results in a preorganization of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c3ae5f96ab4869e6ec456bade5b1dc
https://doi.org/10.1021/acs.jmedchem.7b01304
https://doi.org/10.1021/acs.jmedchem.7b01304
Autor:
James R. McCarthy, T. Sloane Guy
Publikováno v:
AORN journal. 104(4)
Mitral valve dysfunction can seriously impair patients' lives and may require valve repair or replacement. Surgery can be performed using techniques including sternotomy; right thoracotomy with or without robot assistance; and the totally endoscopic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1e99929cfa69a74722bf894e022105
https://pubmed.ncbi.nlm.nih.gov/27692076
https://pubmed.ncbi.nlm.nih.gov/27692076
Publikováno v:
Organic Letters. 11:807-810
Chiral tertiary alpha-hydroxy esters of known stereochemical configuration were transformed to alpha-azido esters by Mitsunobu reaction with HN3. Optimization of this reaction was shown to proceed at room temperature with high chemical yield using 1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56cc8c5c27be83835edbab68a578eb86
https://doi.org/10.1021/ol802325h
https://doi.org/10.1021/ol802325h
Autor:
Michael J. Shapiro, Paloma Vidal, Howard B. Broughton, Alfonso Rivera-Sagredo, James R. McCarthy, Juan F. Espinosa, David E. Timm, Shu-Hui Chen, Jose Alfredo Martin
Publikováno v:
Journal of Medicinal Chemistry. 48:7623-7627
Conformational analysis in solution of β-secretase inhibitors 1 and 2 by NMR spectroscopy reveals that the hydroxyethylene isostere, an apparently flexible fragment widely used as a scissile bond replacement in aspartic protease inhibitors, exists i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c56020a7419847f991f28e9d69420b09
https://doi.org/10.1021/jm050631+
https://doi.org/10.1021/jm050631+
Autor:
Charles Q. Huang, James R. McCarthy, Paul D. Crowe, Raymond S. Gross, John Saunders, Dimitri E. Grigoriadis, Jodene Nelson, Richard Lowe, Brian Dyck, John P. Williams, Dragan Marinkovic, Sam R. J. Hoare, Tim Coon, Robert W. Sullivan, Mustapha Haddach, Said Zamani-Kord, Manisha Moorjani, Zhiqiang Guo, Jane Han Bu, Takung Chen
Publikováno v:
Journal of Medicinal Chemistry. 48:5780-5793
Antagonists of the corticotropin-releasing factor (CRF) neuropeptide should prove to be effective in treating stress and anxiety-related disorders. In an effort to identify antagonists with improved physicochemical properties, new tricyclic CRF(1) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed6584cab9355c213297346348adfa0
https://doi.org/10.1021/jm049085v
https://doi.org/10.1021/jm049085v
Autor:
Said Zamani-Kord, Brian Dyck, Zhiqiang Guo, Robert W. Sullivan, Zhiyong Luo, Raymond S. Gross, Manisha Moorjani, Bin-Feng Li, Mustapha Haddach, John E. Tellew, Mehrak Kiankarimi, Marion Lanier, John P. Williams, James R. McCarthy, Dimitri Grigoriadis, Ta Kung Chen, Paul D. Crowe, John Saunders, Xiaohu Zhang, Jonathan Grey
Publikováno v:
Journal of Medicinal Chemistry. 48:5104-5107
The synthesis and SAR studies of tricyclic imidazo[4,5-b]pyridin-2-ones as human corticotropin-releasing factor receptor (CRF(1)) antagonists are discussed herein. Compound 16g was identified as a functional antagonist that inhibited CRF-stimulated c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815355c45c4d5367cde1ab00c4dece95
https://doi.org/10.1021/jm050384+
https://doi.org/10.1021/jm050384+
Autor:
Amanda Ormsby, Eric P. Zorrilla, Errol B. De Souza, Nicholas Ling, George F. Koob, Gery Schulteis, Alwin Klaassen, James R. McCarthy
Publikováno v:
Brain Research. 952:200-210
Intracerebroventricular (i.c.v.) administration of corticotropin-releasing factor (CRF) biphasically affects performance in tests of learning and memory. In the present study, we used CRF, urocortin (Ucn), a recently cloned CRF homologue, and CRF rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ad41e576ded35f6990ea12ac1c319a
https://doi.org/10.1016/s0006-8993(02)03345-0
https://doi.org/10.1016/s0006-8993(02)03345-0
Autor:
James R. McCarthy
Publikováno v:
Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a07bffd4b139b5eb91bddbbf92255481
https://doi.org/10.1002/9781118739907.ch6
https://doi.org/10.1002/9781118739907.ch6