Zobrazeno 1 - 10
of 25
pro vyhledávání: '"James R Shoblock"'
Autor:
James R. Shoblock, Natalie Welty, Ian Fraser, Ryan Wyatt, Brian Lord, Timothy Lovenberg, Changlu Liu, Pascal Bonaventure
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Recently, our group along with another demonstrated that GPR139 can be activated by L-phenylalanine (L-Phe) and L-tryptophan (L-Trp) at physiologically relevant concentrations. GPR139 is discretely expressed in brain, with highest expression in media
Externí odkaz:
https://doaj.org/article/b638bed54c6b450588caba3fe0f6eff9
Autor:
James R Shoblock, Sandra R. Chaplan, Anthony Ndifor, Steven W. Sutton, Nicholas I. Carruthers, Robin Halter, Michele C. Rizzolio, Ian Fraser, Tatiana Koudriakova, Pascal Bonaventure, Sujin Yun, Leah Aluisio, Christine Dugovic, Zuleima Aguilar, Jonathan Shelton, Brian Lord, Natalie Welty, Timothy W. Lovenberg, Michael A. Letavic, Diane Nepomuceno
Publikováno v:
ResearcherID
Dual orexin receptor antagonists have been shown to promote sleep in various species, including humans. Emerging research indicates that selective orexin-2 receptor (OX2R) antagonists may offer specificity and a more adequate sleep profile by preserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a22e350290152292370d7db2d63f57
https://doi.org/10.1124/jpet.115.225466
https://doi.org/10.1124/jpet.115.225466
Autor:
Terrence Deak, Michael A. Letavic, Anindya Bhattacharya, Marc Ceusters, Elena I. Varlinskaya, Robert Neff, Pascal Bonaventure, Timothy W. Lovenberg, Nicholas I. Carruthers, Wilhelmus Drinkenburg, James R. Shoblock, Brian Lord, Leah Aluisio
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:628-641
In the central nervous system, the ATP-gated Purinergic receptor P2X ligand-gated ion channel 7 (P2X7) is expressed in glial cells and modulates neurophysiology via release of gliotransmitters, including the proinflammatory cytokine interleukin (IL)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a6c9acac974c300114ef70dd7c98a8
https://doi.org/10.1124/jpet.114.218487
https://doi.org/10.1124/jpet.114.218487
Autor:
Robert Neff, Qi Wang, Pascal Bonaventure, Michael A. Letavic, Hong Ao, Leah Aluisio, Natalie Welty, Ian Fraser, Timothy W. Lovenberg, Anindya Bhattacharya, Diane Nepomuceno, James R Shoblock, Alan D. Wickenden, Brian Lord
Publikováno v:
British Journal of Pharmacology. 170:624-640
Background and Purpose An increasing body of evidence suggests that the purinergic receptor P2X, ligand-gated ion channel, 7 (P2X7) in the CNS may play a key role in neuropsychiatry, neurodegeneration and chronic pain. In this study, we characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1b6a790366dc63c534039b82682062d
https://doi.org/10.1111/bph.12314
https://doi.org/10.1111/bph.12314
Autor:
James A. Palmer, Natalie Welty, James R. Shoblock, Leah Aluisio, Nicholas I. Carruthers, Ian Fraser, Pascal Bonaventure, S. Timothy Motley, Timothy W. Lovenberg, Ruggero Galici, Kirsten L. Morton, Jamin D. Boggs
Publikováno v:
Psychopharmacology. 215:191-203
Orexin-1 receptor antagonists have been shown to block the reinforcing effects of drugs of abuse and food. However, whether blockade of orexin-2 receptor has similar effects has not been determined. We have recently described the in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfa317e6424220ebfe6fb5bc1300091
https://doi.org/10.1007/s00213-010-2127-x
https://doi.org/10.1007/s00213-010-2127-x
Autor:
Ruggero Galici, Amir H. Rezvani, Timothy W. Lovenberg, Leah Aluisio, Edward D. Levin, Natalie Welty, Pascal Bonaventure, Christine Dugovic, Jamin D. Boggs, S. Timothy Motley, Michael A. Letavic, Nicholas I. Carruthers, James R. Shoblock, Brian Lord, Ian Fraser
Publikováno v:
Psychopharmacology. 214:829-841
A few recent studies suggest that brain histamine levels and signaling via H(3) receptors play an important role in modulation of alcohol stimulation and reward in rodents.The present study characterized the effects of a novel, selective, and brain p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10df79c01db76937c8b84ea0062099d2
https://doi.org/10.1007/s00213-010-2092-4
https://doi.org/10.1007/s00213-010-2092-4
S170. In Vivo Characterization of an Orally Available, Brain Penetrant Small Molecule GPR139 Agonist
Autor:
Tim Lovenberg, Pascal Bonaventure, Guang Chen, Changlu Liu, Christine Dugovic, Ryan M Wyatt, Ian Fraser, Natalie Welty, James R. Shoblock
Publikováno v:
Biological Psychiatry. 83:S414
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::318800b780128d23be783b896ff74e67
https://doi.org/10.1016/j.biopsych.2018.02.1062
https://doi.org/10.1016/j.biopsych.2018.02.1062
Autor:
Natalie Welty, James R. Shoblock
Publikováno v:
Psychopharmacology. 207:433-438
Histamine H3 receptors (H3R) are presynaptic heteroreceptors that negatively modulate the release of histamine and other neurotransmitters such as acetylcholine. Blocking H3 receptors with antagonists/inverse agonists has been shown to be procognitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbcf757760d5470fb8639a815431349
https://doi.org/10.1007/s00213-009-1670-9
https://doi.org/10.1007/s00213-009-1670-9
Publikováno v:
Neurochemical Research. 29:1437-1442
Amphetamine is more effective than methamphetamine at raising dopamine levels in the prefrontal cortex. The current study tested the hypothesis that norepinephrine transporters are involved in this difference. Using microdialysis, dopamine, norepinep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca6c851aae8d0f3c11f53644bc9c48f
https://doi.org/10.1023/b:nere.0000026409.76261.f3
https://doi.org/10.1023/b:nere.0000026409.76261.f3
Publikováno v:
Psychopharmacology. 170:150-156
Previously, we have shown that d-amphetamine (AMPH) was more potent than d-methamphetamine (METH) at increasing extracellular levels of dopamine (DA) in the prefrontal cortex (PFC) at doses that had similar effects in the nucleus accumbens. Since wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2acb43945eb26c085f4496fc1817660
https://doi.org/10.1007/s00213-003-1522-y
https://doi.org/10.1007/s00213-003-1522-y