Zobrazeno 1 - 10
of 387
pro vyhledávání: '"James R Sellers"'
Autor:
Rong Liu, Neil Billington, Yi Yang, Charles Bond, Amy Hong, Verl Siththanandan, Yasuharu Takagi, James R. Sellers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Myosin-7a is found in actin bundles, microvilli and stereocilia, and plays conserved roles in hearing and vision. Here the authors identify M7BP, a myosin-7a binding protein that activates and dimerizes myosin-7a, enabling cargo transport and assembl
Externí odkaz:
https://doaj.org/article/82ee430ef28b4669aae273c5e81f0e66
Autor:
Wen Lu, Margot Lakonishok, Rong Liu, Neil Billington, Ashley Rich, Michael Glotzer, James R Sellers, Vladimir I Gelfand
Publikováno v:
eLife, Vol 9 (2020)
Local accumulation of oskar (osk) mRNA in the Drosophila oocyte determines the posterior pole of the future embryo. Two major cytoskeletal components, microtubules and actin filaments, together with a microtubule motor, kinesin-1, and an actin motor,
Externí odkaz:
https://doaj.org/article/da1f41b7385848a7b9f2c71e6841a8dd
Autor:
Lucia Gardini, Sarah M. Heissler, Claudia Arbore, Yi Yang, James R. Sellers, Francesco S. Pavone, Marco Capitanio
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Myosin-5B is an actin-based motor important for endosome recycling, but the molecular mechanism underlying its motility remains unknown. Here authors use single molecule imaging and high-speed laser tweezers to dissect the mechanoenzymatic properties
Externí odkaz:
https://doaj.org/article/a663d8e49b69440c972ca488748037c2
A gene duplication of a septin reveals a developmentally regulated filament length control mechanism
Autor:
Kevin S. Cannon, Jose M. Vargas-Muniz, Neil Billington, Ian Seim, Joanne Ekena, James R. Sellers, Amy. S. Gladfelter
Publikováno v:
Journal of Cell Biology. 222
Septins are a family of conserved filament-forming proteins that function in multiple cellular processes. The number of septin genes within an organism varies, and higher eukaryotes express many septin isoforms due to alternative splicing. It is uncl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01e6498eeebdaf500e096053c74e5e29
https://doi.org/10.1083/jcb.202204063
https://doi.org/10.1083/jcb.202204063
Autor:
Luca Melli, Neil Billington, Sara A Sun, Jonathan E Bird, Attila Nagy, Thomas B Friedman, Yasuharu Takagi, James R Sellers
Publikováno v:
eLife, Vol 7 (2018)
Nonmusclemyosin 2 (NM-2) powers cell motility and tissue morphogenesis by assembling into bipolar filaments that interact with actin. Although the enzymatic properties of purified NM-2 motor fragments have been determined, the emergent properties of
Externí odkaz:
https://doaj.org/article/cb1b9d31e9ba413fa47328cdf4cc9808
Autor:
Krishna Chinthalapudi, Sarah M Heissler, Matthias Preller, James R Sellers, Dietmar J Manstein
Publikováno v:
eLife, Vol 6 (2017)
Despite a generic, highly conserved motor domain, ATP turnover kinetics and their activation by F-actin vary greatly between myosin-2 isoforms. Here, we present a 2.25 Å pre-powerstroke state (ADP⋅VO4) crystal structure of the human nonmuscle myos
Externí odkaz:
https://doaj.org/article/e86762993a7243febaacd1f1f457d1c2
Autor:
Alexandra Hollo, Neil Billington, Yasuharu Takagi, Andras Kengyel, James R. Sellers, Rong Liu
Publikováno v:
Biophysical Journal. 122:259a-260a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7a9286d4e2121108c2dbeca4acbb8c3
https://doi.org/10.1016/j.bpj.2022.11.1494
https://doi.org/10.1016/j.bpj.2022.11.1494
Publikováno v:
eLife, Vol 5 (2016)
Non-muscle cell contractility is critical for tissues to adopt shape changes. Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoskeleton networks, recent studies have questioned the impor
Externí odkaz:
https://doaj.org/article/eeb71bd4066e4a7fb4e74e61b434937e
Autor:
Cláudia Brito, Francisco S. Mesquita, Christopher K. E. Bleck, James R. Sellers, Didier Cabanes, Sandra Sousa
Publikováno v:
Toxins, Vol 11, Iss 7, p 419 (2019)
Clostridium perfringens produces an arsenal of toxins that act together to cause severe infections in humans and livestock animals. Perfringolysin O (PFO) is a cholesterol-dependent pore-forming toxin encoded in the chromosome of virtually all C. per
Externí odkaz:
https://doaj.org/article/e0f68f89273e481186ec6499923fb32e
Autor:
Rong Liu, Kasturi Pal, James R. Sellers, Arit Ghosh, Velia M. Fowler, Neil Billington, Roberta B. Nowak
Publikováno v:
Blood
Megakaryocytes (MKs), the precursor cells for platelets, migrate from the endosteal niche of the bone marrow (BM) toward the vasculature, extending proplatelets into sinusoids, where circulating blood progressively fragments them into platelets. Nonm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8dbee44cfc87cfc147f9a4e9868b2e
https://doi.org/10.1182/blood.2019003064
https://doi.org/10.1182/blood.2019003064