Zobrazeno 1 - 10 of 17 pro vyhledávání: '"James R Rose"'
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Akademický článek
Distinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential
Autor: James R. Rose, Bagdeser Akdogan-Ozdilek, Andrew R. Rahmberg, Michael D. Powell, Sakeenah L. Hicks, Christopher D. Scharer, Jeremy M. Boss
Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-19 (2023)
An integrated analysis uncovers transcriptional and epigenetic differences of human circulating memory T cell subsets and identifies unique transcription factor networks associated with memory subset differentiation.
Externí odkaz: https://doaj.org/article/a067bd43035a480cbc06a1f70910044e
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3
An IRF4–MYC–mTORC1 Integrated Pathway Controls Cell Growth and the Proliferative Capacity of Activated B Cells during B Cell Differentiation In Vivo
Autor: Christopher D. Scharer, James R. Rose, Madeline J. Price, Anna K. Kania, Jeremy M. Boss, Dillon G. Patterson
Publikováno v: J Immunol
Cell division is an essential component of B cell differentiation to Ab-secreting plasma cells, with critical reprogramming occurring during the initial stages of B cell activation. However, a complete understanding of the factors that coordinate ear
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295cc11b9b7abbe93a826fea021a83ea
https://doi.org/10.4049/jimmunol.2100440
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4
An IRF4-MYC-mTORC1 integrated pathway controls cell growth and the proliferative capacity of activated B cells during B cell differentiationin vivo
Autor: Jeremy M. Boss, Anna K. Kania, Madeline J. Price, Christopher D. Scharer, James R. Rose, Dillon G. Patterson
Cell division is an essential component of B cell differentiation to antibody-secreting plasma cells, with critical reprogramming occurring during the initial stages of B cell activation. However, a complete understanding of the factors that coordina
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::547e49cfcee74ed51e680df386da520a
https://doi.org/10.1101/2021.06.20.449155
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5
Epigenome accessibility changes before and after activation reveal distinct and progressive differentiation for human memory T cell subsets
Autor: James R Rose, Andrew R Rahmberg, Michael D Powell, Christopher D Scharer, Jeremy M Boss
Publikováno v: The Journal of Immunology. 208:57.02-57.02
Memory T cells (MTC), an indispensable part of adaptive immune memory, have historically been categorized by the cell surface proteins CCR7 and CD45RA into specialized subtypes (TCM, TEM, and TEMRA), each with unique functions. However, the epigeneti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::892654af9b6b9a082f49af0a889820e8
https://doi.org/10.4049/jimmunol.208.supp.57.02
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Defining the cis- and trans-regulatory architecture for human PD-1 in T Follicular Helper Cells
Autor: Michael Duane Powell, James R Rose, Dennis Neeld, Andrew R Rahmberg, Christopher D Scharer, Jeremy M Boss
Publikováno v: The Journal of Immunology. 208:112.21-112.21
The surface immune checkpoint inhibitor Programed Death-1 (PD-1), encoded by PDCD1, is expressed throughout the immune system. Notably, PD-1 expression is amongst its highest in a specialized subset of CD4+ T follicular helper (TFH) cells. TFH cells
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ac96d1a1a583a4634b20ba9d5682702
https://doi.org/10.4049/jimmunol.208.supp.112.21
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7
Unique abilities of human memory T cell subsets are associated with both specialized gene expression modules and epigenetic priming
Autor: James R Rose, Andrew Rahmberg, Christopher Scharer, Jeremy M Boss
Publikováno v: The Journal of Immunology. 206:98.28-98.28
Memory T cells are a diverse set of cells that respond to immunologic challenge more quickly and with greater efficacy than their naïve counterparts. Their potential in the resting and stimulated state has not been explored for each of the subsets.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25d06089575465e308310a45e6e86979
https://doi.org/10.4049/jimmunol.206.supp.98.28
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8
Red blood cell orientation in pulmonary capillaries and its effect on gas diffusion
Autor: Steven J. Janke, Wiltz W. Wagner, William A. Baumgartner, R. L. Capen, James R. Rose, L. Karina Nabors
Publikováno v: Journal of applied physiology (Bethesda, Md. : 1985). 94(4)
When alveoli are inflated, the stretched alveolar walls draw their capillaries into oval cross sections. This causes the disk-shaped red blood cells to be oriented near alveolar gas, thereby minimizing diffusion distance. We tested these ideas by mea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395e8f4fffc0d35a19025e30202e550b
https://pubmed.ncbi.nlm.nih.gov/12626477
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9
Risk Management for Jet Propulsion Laboratory (JPL) Flight Projects
Autor: James R. Rose
Publikováno v: Safety Engineering and Risk Analysis.
RISK MANAGEMENT IN THE PROGRAM/PROJECT ENVIRONMENT: The Risk Management process is assuming greater influence in the process of Project and Program Management. The requirements of NPG 7120.5A [NPG, 1998] have created inroads for the results of identi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ceb368902786f74203f5ad384c3504e
https://doi.org/10.1115/imece2000-1015
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