Zobrazeno 1 - 10
of 78
pro vyhledávání: '"James R Roede"'
Autor:
Stefanos Aivazidis, Abhilasha Jain, Abhishek K Rauniyar, Colin C Anderson, John O Marentette, David J Orlicky, Kristofer S Fritz, Peter S Harris, David Siegel, Kenneth N Maclean, James R Roede
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0223254 (2019)
Down syndrome (DS) is a chromosomal disorder caused by trisomy of chromosome 21 (Ts21). Unbalanced karyotypes can lead to dysfunction of the proteostasis network (PN) and disrupted proteostasis is mechanistically associated with multiple DS comorbidi
Externí odkaz:
https://doaj.org/article/24aeb528ccdd44e88105396de46ec8d6
Autor:
Stefanos Aivazidis, Christina M Coughlan, Abhishek K Rauniyar, Hua Jiang, L Alexander Liggett, Kenneth N Maclean, James R Roede
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176307 (2017)
Down syndrome (DS) is a genetic disorder caused by trisomy of chromosome 21. Abnormalities in chromosome number have the potential to lead to disruption of the proteostasis network (PN) and accumulation of misfolded proteins. DS individuals suffer fr
Externí odkaz:
https://doaj.org/article/978e9b7f17484af897c51cbdd8010be6
Autor:
James R Roede, Karan Uppal, Youngja Park, Kichun Lee, Vilinh Tran, Douglas Walker, Frederick H Strobel, Shannon L Rhodes, Beate Ritz, Dean P Jones
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77629 (2013)
Progression of Parkinson's disease (PD) is highly variable, indicating that differences between slow and rapid progression forms could provide valuable information for improved early detection and management. Unfortunately, this represents a complex
Externí odkaz:
https://doaj.org/article/a5960dc0a1ef44ce850deec120273442
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33020 (2012)
Mitochondrial phenotype is complex and difficult to define at the level of individual cell types. Newer metabolic profiling methods provide information on dozens of metabolic pathways from a relatively small sample. This pilot study used "top-down" m
Externí odkaz:
https://doaj.org/article/d9a09667df44436392445c04a77c841f
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18918 (2011)
Cell culture studies show that the antioxidant thiol protein, thioredoxin-1 (Trx1), translocates to cell nuclei during stress, facilitates DNA binding of transcription factors NF-κB and glucocorticoid receptor (GR) and potentiates signaling in immun
Externí odkaz:
https://doaj.org/article/b35044d49e784bb3bef8b7c262f1d806
Autor:
Ashwini Sri Hari, Rajeswari Banerji, Li-Ping Liang, Ruth E. Fulton, Christopher Quoc Huynh, Timothy Fabisiak, Pallavi Bhuyan McElroy, James R. Roede, Manisha Patel
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102895- (2023)
Glutathione (GSH) depletion, and impaired redox homeostasis have been observed in experimental animal models and patients with epilepsy. Pleiotropic strategies that elevate GSH levels via transcriptional regulation have been shown to significantly de
Externí odkaz:
https://doaj.org/article/ed4713f353534d5c94fce6e8d5efe468
Autor:
Peter S. Harris, Courtney D. McGinnis, Cole R. Michel, John O. Marentette, Richard Reisdorph, James R. Roede, Kristofer S. Fritz
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102792- (2023)
In the U.S., alcohol-associated liver disease (ALD) impacts millions of people and is a major healthcare burden. While the pathology of ALD is unmistakable, the molecular mechanisms underlying ethanol hepatotoxicity are not fully understood. Hepatic
Externí odkaz:
https://doaj.org/article/450bbd80f87647e9beada0434ab3076c
Publikováno v:
Free Radical Biology and Medicine. 196:11-21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::333fa7f12b3f757cf5e28d80ec6917a2
https://doi.org/10.1016/j.freeradbiomed.2023.01.009
https://doi.org/10.1016/j.freeradbiomed.2023.01.009
Autor:
James R. Roede, John O. Marentette, Angelo D'Alessandro, Kenneth N. Maclean, Kendra M. Prutton, Julie A. Reisz, Colin C. Anderson, Abhishek K. Rauniyar, Laura Saba
Publikováno v:
Free Radic Biol Med
Down syndrome (DS) is the most common genetic cause of intellectual disability. Mechanistically, oxidative stress and mitochondrial dysfunction are reported to be etiological factors for many of the DS-related comorbidities and have previously been r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d080ea5f4e69c829325b7bbc7d68db
https://doi.org/10.1016/j.freeradbiomed.2021.06.003
https://doi.org/10.1016/j.freeradbiomed.2021.06.003
Autor:
Kenneth N. Maclean, Hua Jiang, Whitney N. Phinney, James R. Roede, Bailey M. Mclagan, Sally P. Stabler
Publikováno v:
Molecular Genetics and Metabolism. 132:128-138
Cystathionine beta-synthase deficient homocystinuria (HCU) is a life-threatening disorder of sulfur metabolism. Our knowledge of the metabolic changes induced in HCU are based almost exclusively on data derived from plasma. In the present study, we p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761ae7310efc824b57493638756cfc4c
https://doi.org/10.1016/j.ymgme.2021.01.003
https://doi.org/10.1016/j.ymgme.2021.01.003