Zobrazeno 1 - 10
of 17
pro vyhledávání: '"James R Partridge"'
Autor:
Juan A. Perez-Bermejo, Oghene Efagene, William M. Matern, Jeffrey K. Holden, Shaheen Kabir, Glen M. Chew, Gaia Andreoletti, Eniola Catton, Craig L. Ennis, Angelica Garcia, Trevor L. Gerstenberg, Kaisle A. Hill, Aayami Jain, Kristina Krassovsky, Cassandra D. Lalisan, Daniel Lord, B. Joy Quejarro, Jade Sales-Lee, Meet Shah, Brian J. Silva, Jason Skowronski, Yuri G. Strukov, Joshua Thomas, Michael Veraz, Twaritha Vijay, Kirby A. Wallace, Yue Yuan, Jane L. Grogan, Beeke Wienert, Premanjali Lahiri, Sebastian Treusch, Daniel P. Dever, Vanessa B. Soros, James R. Partridge, Kristen L. Seim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Homology Directed Repair (HDR) enables precise genome editing, but the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such as Non-Homologous End Jo
Externí odkaz:
https://doaj.org/article/620ea33bf16f4f77a76fcba73efa8992
Publikováno v:
eLife, Vol 3 (2014)
Hsp90 is a conserved chaperone that facilitates protein homeostasis. Our crystal structure of the mitochondrial Hsp90, TRAP1, revealed an extension of the N-terminal β-strand previously shown to cross between protomers in the closed state. In this s
Externí odkaz:
https://doaj.org/article/bc528b39f216455e85ca326e00eb0884
Autor:
Alexey Dementiev, Abel Silva, Calvin Yee, Zhe Li, Michael T. Flavin, Hing Sham, James R. Partridge
Publikováno v:
Blood Advances, Vol 2, Iss 5, Pp 549-558 (2018)
Abstract: Activated factor XIIa (FXIIa) is a serine protease that has received a great deal of interest in recent years as a potential target for the development of new antithrombotics. Despite the strong interest in obtaining structural information,
Externí odkaz:
https://doaj.org/article/7129089a7ea744118c8a866d33651f42
Autor:
Ying Zhang, James R. Partridge, Qiong Xu, Peter Rademacher, Zhe Li, Andreas Betz, Haijuan Shi, Hing Sham, Abel Silva-Garcia, Li Zhang, Xubo Ma, Bin Liu, Qing Xu, Yuqing Shan, Yunjin Hu
Publikováno v:
ACS Medicinal Chemistry Letters. 8:185-190
A series of macrocyclic analogues were designed and synthesized based on the cocrystal structure of small molecule plasma kallikrein (pKal) inhibitor, 2, with the pKal protease domain. This led to the discovery of a potent macrocyclic pKal inhibitor
Autor:
Brian Metcalf, Abel Silva-Garcia, Rebeca M. Choy, Zhe Li, James R. Partridge, Chul Yu, Hing Sham
Publikováno v:
Journal of structural biology. 206(2)
Plasma kallikrein (pKal) is a serine protease responsible for cleaving high-molecular-weight kininogen to produce the pro-inflammatory peptide, bradykinin. Unregulated pKal activity can lead to hereditary angioedema (HAE) following excess bradykinin
Autor:
Athiwat Hutchaleelaha, Harris Jason R, Qing Xu, Donna Oksenberg, Matthew P. Jacobson, Carl Johnson, Larysa N. Patskovska, Zhe Li, Joyce James, Qing Lu, Paulvannan Kumar, Chihyuan Chuang, Donghong Xu, Yury Patskovsky, Lan Hua, Abel Silva-Garcia, Kobina Dufu, Brian Metcalf, Bradley P Morgan, James R. Partridge, Stephen L Gwaltney, Calvin Yee, Mira Patel, Steven C. Almo
We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440 (36), that increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions. Unlike earlier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474bb23099c36d4a59ac8cad2e76a0d7
https://europepmc.org/articles/PMC5346980/
https://europepmc.org/articles/PMC5346980/
Autor:
Theresa Ramelot, Laura A. Lavery, Daniel Elnatan, James R. Partridge, David A. Agard, Michael A. Kennedy
Publikováno v:
Molecular Cell. 53(2):330-343
Summary While structural symmetry is a prevailing feature of homo-oligomeric proteins, asymmetry provides unique mechanistic opportunities. We present the crystal structure of full-length TRAP1, the mitochondrial Hsp90 molecular chaperone, in a catal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7068-7071
Described is the synthesis of three different fluorescein-tagged derivatives of a macrocycle, and their binding affinity to heat shock protein 90 (Hsp90). Using fluorescence polarization anisotropy, we report the binding affinity of these fluorescein
Autor:
Roger Cooke, Nariman Naber, Daniel Elnatan, Laura A. Lavery, James R. Partridge, David A. Agard
Publikováno v:
eLife
eLife, Vol 3 (2014)
eLife, Vol 3 (2014)
Hsp90 is a conserved chaperone that facilitates protein homeostasis. Our crystal structure of the mitochondrial Hsp90, TRAP1, revealed an extension of the N-terminal β-strand previously shown to cross between protomers in the closed state. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a475cc7c749c003558ec394f5bdf6869
https://escholarship.org/uc/item/7sx555bb
https://escholarship.org/uc/item/7sx555bb