Zobrazeno 1 - 10
of 23
pro vyhledávání: '"James R Merson"'
Autor:
David C Pryde, Lyn H Jones, David P Gervais, David R Stead, David C Blakemore, Matthew D Selby, Alan D Brown, Jotham W Coe, Matthew Badland, David M Beal, Rebecca Glen, Yvonne Wharton, Gavin J Miller, Phil White, Ningli Zhang, Michelle Benoit, Karen Robertson, James R Merson, Heather L Davis, Michael J McCluskie
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76557 (2013)
Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodies (Ab) which reduce nicotine entering the brain, and hence the associated reward. Ab function depends on both the quantity (titer) and the quality (affinity)
Externí odkaz:
https://doaj.org/article/d241124036e24c84ac8c79ff70c995d1
Autor:
Bassel Akache, Risini D. Weeratna, Aparna Deora, Jennifer M. Thorn, Brian Champion, James R. Merson, Heather L. Davis, Michael J. McCluskie
Publikováno v:
Vaccines, Vol 4, Iss 1, p 3 (2016)
Qb bacteriophage virus-like particles (Qb-VLP) are utilized as carriers to enhance immune responses to weakly or non-immunogenic antigens such as peptides and haptens. Qb-VLPs are formed through the self-assembly of multiple Qb capsid protein monomer
Externí odkaz:
https://doaj.org/article/7eeef5d9221c4965aaafaaaedea31041
Autor:
Heather L. Davis, Brian Robert Champion, Ghania Chikh, James D. Fraser, Lu Zhang, James R. Merson, Michael J. McCluskie, Jennifer Marie Thorn, Risini D. Weeratna
Publikováno v:
Immunity, Inflammation and Disease
The anti‐human immunoglobulin E (IgE) monoclonal antibody, omalizumab (Xolair®, Genentech, South San Fransisco, CA), is effective in the treatment of poorly controlled moderate to severe allergic asthma and chronic idiopathic urticaria. It acts by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a52465f12853abfab9920596b30c2b
https://doi.org/10.1002/iid3.98
https://doi.org/10.1002/iid3.98
Autor:
Julia Li, J. Erik Johnson, Derek John Falconer, Kate West, Kathrin U. Jansen, Oscar Maldonado, Susanne Lang, Jim E. Eyles, Cheryl S. Kotash, Shawn R. Makinen, Phil White, Risini D. Weeratna, James R. Merson, Thomas P. Brown, Paul Wright, George J. Smith, Clare Lees, Susan E. Witko, Paul Cockle, Vidia Roopchand, Peter T. Loudon, Shakuntala Megati, Maninder K. Sidhu
Publikováno v:
Journal of Infectious Diseases. 208:319-329
Background. We evaluated the immunological responses of African green monkeys immunized with multiple F and G protein–based vaccines and assessed protection against the Memphis 37 strain of respiratory syncytial virus (RSV). Methods. Monkeys were i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d322dd2583760ad8a2e105c4aaeac2a
https://doi.org/10.1093/infdis/jit169
https://doi.org/10.1093/infdis/jit169
Autor:
Bruce A. Green, Richard J. Anderson, Derek John Falconer, Neil C. Sheppard, Shawn R. Makinen, Anne-Laure Goenaga, Stephen J. Gracheck, Jim E. Eyles, James R. Merson, Risini D. Weeratna, Susanne Lang, Siradanahalli Guru, Bingsheng Chang
Publikováno v:
Vaccine. 34(50)
We evaluated 52 different E. coli expressed pneumococcal proteins as immunogens in a BALB/c mouse model of S. pneumoniae lung infection. Proteins were selected based on genetic conservation across disease-causing serotypes and bioinformatic predictio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0e1d47c7a0000dc87f3533c4098fdd
https://pubmed.ncbi.nlm.nih.gov/27816374
https://pubmed.ncbi.nlm.nih.gov/27816374
Autor:
James R. Merson, Lianchun Chen, In-Jeong Kim, Daisy Hammond, Clare Christy, Tharsika Tharmanathan, R. Brad Jones, Heather A. Simmons, Mario A. Ostrowski, Kerry A Beheler, Eva G. Rakasz, Jakir Hussain Ullah, Neil C. Sheppard, Carla Fernandes, Dusko Trajkovic, Peter T. Loudon, Douglas F. Nixon, Jonah B. Sacha, Philip A. Castrovinci, Jason S. Reed, Melanie Rieger, Patrick B. Lappin, Ingrid M. Pruimboom-Brees, Daniel Schenkman, Juliann Janies, Ningli Zhang, Joseph P. Gardner, Sing Rong, Douglas H Gebhard, Ahmed M. Shoieb, Michael J. McCluskie, Shari M. Piaskowski, Klaus Rumpel, Laura Newman, Francesca A. Nimityongskul, Robert J Gifford, Brian G. Pierce, Frederike von Pelchrzim, David A. Goodwin, Sophie Muscat-King, Samantha E. Wildeboer
Publikováno v:
The Journal of Immunology. 189:1467-1479
The expression of endogenous retrotransposable elements, including long interspersed nuclear element 1 (LINE-1 or L1) and human endogenous retrovirus, accompanies neoplastic transformation and infection with viruses such as HIV. The ability to engend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7367f62dea46e68bcbd19dc7596b7d1
https://doi.org/10.4049/jimmunol.1200079
https://doi.org/10.4049/jimmunol.1200079
Publikováno v:
Drug Discovery Today. 14:1037-1044
Healthcare costs in all industrial nations have increased and payors are starting to look at new ways to contain costs and at new funding models. The business model of pharmaceutical companies is also undergoing rapid changes – potentially disrupti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52864f959a3b994107600dc352010cda
https://doi.org/10.1016/j.drudis.2009.07.008
https://doi.org/10.1016/j.drudis.2009.07.008
Publikováno v:
Journal of Chromatography B. 817:77-80
This communication describes the invention and further development of the first 96-well solid-phase extraction system and the original purposes to which it was put. We also describe the adaption of this system for bioanalysis of pharmaceutically acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e174c1a9c46482b20497800c180e5b
https://doi.org/10.1016/j.jchromb.2004.08.029
https://doi.org/10.1016/j.jchromb.2004.08.029
Autor:
Helen Kim Cho, Terrence Coleman, Steve Burgess, Joan Guo, Terri Harder, Oscar Maldonado, Dan Xu, James R. Merson, Cindy Wei Li, Kam Chan, Paul Cockle, Karin Jooss, Steve Kurzyniec
Publikováno v:
Journal of Clinical Oncology. 35:e23084-e23084
e23084 Background: Sunitinib is a receptor tyrosine kinase inhibitor (RTK) approved as a monotherapy for the treatment of advanced RCC, gastrointestinal stromal tumors and advanced pancreatic neuroendocrine tumors. At the approved doses, it inhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47be6407f38c900efbbf8291c3f1df0d
https://doi.org/10.1200/jco.2017.35.15_suppl.e23084
https://doi.org/10.1200/jco.2017.35.15_suppl.e23084
Autor:
Keshab Bhattacharya, Jennifer Marie Thorn, Michael J. McCluskie, Ghania Chikh, Jari I. Finneman, Dana M. Evans, Ningli Zhang, Heather L. Davis, James R. Merson, Paul Robert Mehelic, David Robert Stead, Michele Bailey Piatchek, Janna Cartier, Parag Kolhe
Publikováno v:
International immunopharmacology. 25(2)
Anti-nicotine vaccines aim to prevent nicotine entering the brain, and thus reduce or eliminate the reward that drives nicotine addiction. Those tested in humans to date have failed to improve quit rates over placebo, possibly because antibody (Ab) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f927cafb6fa8190aeb42bfc93f4eb5
https://pubmed.ncbi.nlm.nih.gov/25737198
https://pubmed.ncbi.nlm.nih.gov/25737198