Zobrazeno 1 - 10
of 85
pro vyhledávání: '"James R Krycer"'
Autor:
Deanne Francis, Shila Ghazanfar, Essi Havula, James R Krycer, Dario Strbenac, Alistair Senior, Annabel Y Minard, Thomas Geddes, Marin E Nelson, Fiona Weiss, Jacqueline Stöckli, Jean Y H Yang, David E James
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 10 (2021)
AbstractGenetic and environmental factors play a major role in metabolic health. However, they do not act in isolation, as a change in an environmental factor such as diet may exert different effects based on an individual’s genotype. Here, we soug
Externí odkaz:
https://doaj.org/article/22e39aa89e95440c9394f276fad33aca
Publikováno v:
BioTechniques, Vol 67, Iss 3, Pp 123-125 (2019)
Metabolism is often studied in animal models, with the Drosophila melanogaster fruit fly model offering ease of genetic manipulation and high-throughput studies. Fly metabolism is typically studied using end-point assays that are simple but destructi
Externí odkaz:
https://doaj.org/article/e4a825ebdeb44e4db1ec25f6f4e60059
Autor:
Daniel J Fazakerley, Rima Chaudhuri, Pengyi Yang, Ghassan J Maghzal, Kristen C Thomas, James R Krycer, Sean J Humphrey, Benjamin L Parker, Kelsey H Fisher-Wellman, Christopher C Meoli, Nolan J Hoffman, Ciana Diskin, James G Burchfield, Mark J Cowley, Warren Kaplan, Zora Modrusan, Ganesh Kolumam, Jean YH Yang, Daniel L Chen, Dorit Samocha-Bonet, Jerry R Greenfield, Kyle L Hoehn, Roland Stocker, David E James
Publikováno v:
eLife, Vol 7 (2018)
Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial coenzyme Q (CoQ) in insulin-resistant adipose and muscle tissue. This defect was observed in a ra
Externí odkaz:
https://doaj.org/article/8a5796fc74b24c25b9c3c989e6b15e61
Autor:
Westa Domanova, James R Krycer, Rima Chaudhuri, Pengyi Yang, Fatemeh Vafaee, Daniel J Fazakerley, Sean J Humphrey, David E James, Zdenka Kuncic
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185871 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0157763.].
Externí odkaz:
https://doaj.org/article/aa8235c3b17140e59f0245d0ee9013ed
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164535 (2016)
Transcription factors (TFs) play a fundamental role in coordinating biological processes in response to stimuli. Consequently, we often seek to determine the key TFs and their regulated target genes (TGs) amidst gene expression data. This requires a
Externí odkaz:
https://doaj.org/article/3bd575a2bf174711b404184667f262be
Autor:
Rachael Fletcher, Christopher Gribben, Xiuquan Ma, James G Burchfield, Kristen C Thomas, James R Krycer, David E James, Daniel J Fazakerley
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95598 (2014)
The Niemann-Pick disease, type C1 (NPC1) gene encodes a transmembrane protein involved in cholesterol efflux from the lysosome. SNPs within NPC1 have been associated with obesity and type 2 diabetes, and mice heterozygous or null for NPC1 are insulin
Externí odkaz:
https://doaj.org/article/bc28627d325f4b2eb2736832c82d3e5f
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83888 (2013)
The precise assembly of specific DNA sequences is a critical technique in molecular biology. Traditional cloning techniques use restriction enzymes and ligation of DNA in vitro, which can be hampered by a lack of appropriate restriction-sites and ine
Externí odkaz:
https://doaj.org/article/6f2a2dd727844883bfbb4c33abb9d446
Autor:
Daniel J. Fazakerley, Julian van Gerwen, Kristen C. Cooke, Xiaowen Duan, Elise J. Needham, Alexis Díaz-Vegas, Søren Madsen, Dougall M. Norris, Amber S. Shun-Shion, James R. Krycer, James G. Burchfield, Pengyi Yang, Mark R. Wade, Joseph T. Brozinick, David E. James, Sean J. Humphrey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The failure of metabolic tissues to respond to insulin is an early marker of type 2 diabetes. Here, the authors show, using global phosphoproteomics, that insulin resistance is caused by a marked rewiring of both canonical and non-canonical insulin s
Externí odkaz:
https://doaj.org/article/1d1d85eedd7542a2a8117c06e8ff0883
Autor:
James R. Krycer, Sam P. Nayler
Publikováno v:
The Cerebellum. 21:838-850
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f3626a5c29ba26ee7d4ffbcce1fef9
https://doi.org/10.1007/s12311-022-01415-2
https://doi.org/10.1007/s12311-022-01415-2
Autor:
Joycelyn Tan, Sam Virtue, Dougall M. Norris, Olivia J. Conway, Ming Yang, Christopher Gribben, Fatima Lugtu, Ioannis Kamzolas, James R. Krycer, Richard J. Mills, Conceição Pereira, Martin Dale, Amber S. Shun-Shion, Harry J. M. Baird, James A. Horscroft, Alice P. Sowton, Marcella Ma, Stefania Carobbio, Evangelia Petsalaki, Andrew J. Murray, David C. Gershlick, James E. Hudson, Ludovic Vallier, Kelsey H Fisher-Wellman, Christian Frezza, Antonio Vidal-Puig, Daniel J. Fazakerley
SUMMARYCell culture is generally considered to be hyperoxic. However, the importance of cellular oxygen consumption is often underappreciated, with rates of oxygen consumption often sufficient to cause hypoxia at cell monolayers. We initially focused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fe7ad781bc0666a5a17fe82ad499dc9
https://doi.org/10.1101/2022.11.29.516437
https://doi.org/10.1101/2022.11.29.516437
