Zobrazeno 1 - 10
of 142
pro vyhledávání: '"James R Fuchs"'
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
Autor:
Pratibha C Koneru, Ashwanth C Francis, Nanjie Deng, Stephanie V Rebensburg, Ashley C Hoyte, Jared Lindenberger, Daniel Adu-Ampratwum, Ross C Larue, Michael F Wempe, Alan N Engelman, Dmitry Lyumkis, James R Fuchs, Ronald M Levy, Gregory B Melikyan, Mamuka Kvaratskhelia
Publikováno v:
eLife, Vol 8 (2019)
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we show that lead pyridine-based ALLINI KF116 exhibits striking
Externí odkaz:
https://doaj.org/article/f3f96045b25c4b55a0b26306772c43fd
Autor:
Janet L. Oblinger, Jack Wang, Georgia D. Wetherell, Garima Agarwal, Tyler A. Wilson, Nicole R. Benson, Joelle M. Fenger, James R. Fuchs, A. Douglas Kinghorn, Long-Sheng Chang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Inhibition of translation initiation using eIF4A inhibitors like (−)-didesmethylrocaglamide [(−)-DDR] and (−)-rocaglamide [(−)-Roc] is a potential cancer treatment strategy as they simultaneously diminish multiple oncogenic drivers.
Externí odkaz:
https://doaj.org/article/9f51765470304068adff9d89398af258
Autor:
Tung Dinh, Zahira Tber, Juan S. Rey, Seema Mengshetti, Arun S. Annamalai, Reed Haney, Lorenzo Briganti, Franck Amblard, James R. Fuchs, Peter Cherepanov, Kyungjin Kim, Raymond F. Schinazi, Juan R. Perilla, Baek Kim, Mamuka Kvaratskhelia
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are investigational antiretroviral agents that potently impair virion maturation by inducing hyper-multimerization of IN and inhibiting its interaction with viral genomic RNA. The pyrrolop
Externí odkaz:
https://doaj.org/article/c69147de7e574451940943ace37a1646
Autor:
Anand eKumar, Mary eDrozd, Ruby ePina-Mimbela, Xiulan eXu, Yosra A Helmy, Janet eAntwi, James R Fuchs, Corey eNislow, Jillian eTempleton, Patrick J Blackall, Gireesh eRajashekara
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Campylobacter is a leading cause of foodborne bacterial gastroenteritis worldwide and infections can be fatal. The emergence of antibiotic-resistant Campylobacter spp. necessitates the development of new antimicrobials. We identified novel anti-Campy
Externí odkaz:
https://doaj.org/article/68c911ff88774583972760b2f099913c
Autor:
Amit Sharma, Alison Slaughter, Nivedita Jena, Lei Feng, Jacques J Kessl, Hind J Fadel, Nirav Malani, Frances Male, Li Wu, Eric Poeschla, Frederic D Bushman, James R Fuchs, Mamuka Kvaratskhelia
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004171 (2014)
The quinoline-based allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are promising candidates for clinically useful antiviral agents. Studies using these compounds have highlighted the role of IN in both early and late stages of virus replication
Externí odkaz:
https://doaj.org/article/7ceda5ee2d6f497c8ecf7da87f9b4d83
Autor:
Matthew A Bill, Courtney Nicholas, Thomas A Mace, Jonathan P Etter, Chenglong Li, Eric B Schwartz, James R Fuchs, Gregory S Young, Li Lin, Jiayuh Lin, Lei He, Mitch Phelps, Pui-Kai Li, Gregory B Lesinski
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e40724 (2012)
The Janus kinase-2 (Jak2)-signal transducer and activator of transcription-3 (STAT3) pathway is critical for promoting an oncogenic and metastatic phenotype in several types of cancer including renal cell carcinoma (RCC) and melanoma. This study desc
Externí odkaz:
https://doaj.org/article/5599ab05f7594c22bf3b3ba8343111bc
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-19 (2023)
Abstract Retrosynthesis is a procedure where a target molecule is transformed into potential reactants and thus the synthesis routes can be identified. Recently, computational approaches have been developed to accelerate the design of synthesis route
Externí odkaz:
https://doaj.org/article/480fb60db89f4f459d39885a7d8ea005
Autor:
Debasmita Mukherjee, Srija Chakraborty, Lena Bercz, Liliana D’Alesio, Jessica Wedig, Molly A. Torok, Timothy Pfau, Hannah Lathrop, Shrina Jasani, Abigail Guenther, Jake McGue, Daniel Adu-Ampratwum, James R. Fuchs, Timothy L. Frankel, Maciej Pietrzak, Stacey Culp, Anne M. Strohecker, Aleksander Skardal, Thomas A. Mace
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107408- (2023)
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high metastasis and therapeutic resistance. Activating transcription factor 4 (ATF4), a master regulator of cellular stress, is exploited by cancer cells to survive. Prior
Externí odkaz:
https://doaj.org/article/a4781aeac6144f15a1769afbae4e87be
Autor:
Yosra A. Helmy, Dipak Kathayat, Gary Closs, Jr, Katie Galgozy, James R. Fuchs, Gireesh Rajashekara
Publikováno v:
Poultry Science, Vol 102, Iss 4, Pp 102543- (2023)
ABSTRACT: Avian pathogenic E. coli (APEC), a causative agent of colibacillosis, is associated with high mortality and morbidity which results in severe economic losses to the poultry industry worldwide. APEC can be transmitted to humans through the c
Externí odkaz:
https://doaj.org/article/c86c18046e8e48ba8ddaec67476f2467
Autor:
Amrita Salvi, Alexandria N. Young, Andrew C. Huntsman, Melissa R. Pergande, Melissa A. Korkmaz, Rathnayake A. Rathnayake, Brittney K. Mize, A. Douglas Kinghorn, Xiaoli Zhang, Kiira Ratia, Markus Schirle, Jason R. Thomas, Scott M. Brittain, Claude Shelton, Leslie N. Aldrich, Stephanie M. Cologna, James R. Fuchs, Joanna E. Burdette
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract PHY34 is a synthetic small molecule, inspired by a compound naturally occurring in tropical plants of the Phyllanthus genus. PHY34 was developed to have potent in vitro and in vivo anticancer activity against high grade serous ovarian cancer
Externí odkaz:
https://doaj.org/article/e4c4de122bed46cdace434fd84397a5c