Zobrazeno 1 - 10
of 139
pro vyhledávání: '"James R Edwards"'
Publikováno v:
JBMR Plus, Vol 4, Iss 4, Pp n/a-n/a (2020)
ABSTRACT Bone is the most common site for cancer metastasis. Understanding the interactions within the complex, heterogeneous bone–tumor microenvironment is essential for the development of new therapeutics. Various animal models of tumor‐induced
Externí odkaz:
https://doaj.org/article/6fa6a938d0ff4957bf124d07620984db
Autor:
Sally Roberts, Pauline Colombier, Aneka Sowman, Claire Mennan, Jan H D Rölfing, Jérôme Guicheux, James R Edwards
Publikováno v:
Acta Orthopaedica, Vol 87, Iss 0, Pp 15-25 (2016)
The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, an
Externí odkaz:
https://doaj.org/article/cea835fa55b541ecb868140c9ea446ba
Autor:
Indong Jun, Haneul Choi, Hyeok Kim, Byoung Chan Choi, Hye Jung Chang, Youngjun Kim, Sung Woo Cho, James R. Edwards, Suk-Won Hwang, Yu-Chan Kim, Hyung-Seop Han, Hojeong Jeon
Publikováno v:
Bioactive Materials, Vol 43, Iss , Pp 181-194 (2025)
Medical stents are vital for treating vascular complications and restoring blood flow in millions of patients. Despite its widespread effectiveness, restenosis, driven by the complex interplay of cellular responses, remains a concern. This study inve
Externí odkaz:
https://doaj.org/article/c9281dee1c3d4917986a7658158b1304
Autor:
Renjie Jin, Julie A Sterling, James R Edwards, David J DeGraff, Changki Lee, Serk In Park, Robert J Matusik
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60983 (2013)
Patients with advanced prostate cancer almost invariably develop osseous metastasis. Although many studies indicate that the activation of NF-κB signaling appears to be correlated with advanced cancer and promotes tumor metastasis by influencing tum
Externí odkaz:
https://doaj.org/article/3da69e9310274a289a67ded6d40db1f4
Autor:
Sophie Thiolloy, James R Edwards, Barbara Fingleton, Daniel B Rifkin, Lynn M Matrisian, Conor C Lynch
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29862 (2012)
Breast to bone metastases frequently induce a "vicious cycle" in which osteoclast mediated bone resorption and proteolysis results in the release of bone matrix sequestered factors that drive tumor growth. While osteoclasts express numerous proteinas
Externí odkaz:
https://doaj.org/article/92a678089e744f57baf73db6171a78ed
Autor:
Junling Zhuang, Jianghong Zhang, Seint T Lwin, James R Edwards, Claire M Edwards, Gregory R Mundy, Xiangli Yang
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48871 (2012)
Osteoclasts play a key role in the development of cancer-associated osteolytic lesions. The number and activity of osteoclasts are often enhanced by tumors. However, the origin of osteoclasts is unknown. Myeloid-derived suppressor cells (MDSCs) are o
Externí odkaz:
https://doaj.org/article/15a7c25cae2e4fb6bd61d4edac76001a
Autor:
Rongrong Zhang, James R Edwards, Seon-Yle Ko, Shanshan Dong, Hongbin Liu, Babatunde O Oyajobi, Christopher Papasian, Hong-Wen Deng, Ming Zhao
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20780 (2011)
Intermittent application of parathyroid hormone (PTH) has well established anabolic effects on bone mass in rodents and humans. Although transcriptional mechanisms responsible for these effects are not fully understood, it is recognized that transcri
Externí odkaz:
https://doaj.org/article/6d65e903074e4acb865a9ecd0acb4731
Autor:
Daniele T. Cotton, Joseph A.E. Morgan, Alexander Feuerborn, James R. Edwards, Srinivasa R. Rao, Edmond J. Walsh, Claire M. Edwards
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100552- (2024)
Externí odkaz:
https://doaj.org/article/85d69e4057e440cc8f3cf4066b183903
The Species Effect: Differential Sphingosine-1-Phosphate Responses in the Bone in Human Versus Mouse
Autor:
Kathryn Frost, Jonathan W. Lewis, Simon W. Jones, James R. Edwards, Amy J. Naylor, Helen M. McGettrick
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5118 (2024)
The deterioration of osteoblast-led bone formation and the upregulation of osteoclast-regulated bone resorption are the primary causes of bone diseases, including osteoporosis. Numerous circulating factors play a role in bone homeostasis by regulatin
Externí odkaz:
https://doaj.org/article/270add971bb84a9f9ebb0ea93106d86b
Autor:
Parinya Samakkarnthai, Dominik Saul, Lei Zhang, Zaira Aversa, Madison L. Doolittle, Jad G. Sfeir, Japneet Kaur, Elizabeth J. Atkinson, James R. Edwards, Graham G. Russell, Robert J. Pignolo, James L. Kirkland, Tamar Tchkonia, Laura J. Niedernhofer, David G. Monroe, Nathan K. Lebrasseur, Joshua N. Farr, Paul D. Robbins, Sundeep Khosla
Publikováno v:
Aging. 15:3331-3355
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3728151fc14d831eec927a8a779b648
https://doi.org/10.18632/aging.204701
https://doi.org/10.18632/aging.204701