Zobrazeno 1 - 10
of 81
pro vyhledávání: '"James R Dutton"'
Autor:
Seongjun So, Yeonmi Lee, Jiwan Choi, Seoon Kang, Ji-Yoon Lee, Julie Hwang, Joosung Shin, James R Dutton, Eul-Ju Seo, Beom Hee Lee, Chong Jai Kim, Shoukhrat Mitalipov, Soo Jin Oh, Eunju Kang
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233057 (2020)
Poor survival of human pluripotent stem cells (hPSCs) following freezing, thawing, or passaging hinders the maintenance and differentiation of stem cells. Rho-associated kinases (ROCKs) play a crucial role in hPSC survival. To date, a typical ROCK in
Externí odkaz:
https://doaj.org/article/7a20225a742d4ddd8bcbbb45190f4ce2
Autor:
Zhouhui Geng, Patrick J Walsh, Vincent Truong, Caitlin Hill, Mara Ebeling, Rebecca J Kapphahn, Sandra R Montezuma, Ching Yuan, Heidi Roehrich, Deborah A Ferrington, James R Dutton
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173575 (2017)
Fidelity in pluripotent stem cell differentiation protocols is necessary for the therapeutic and commercial use of cells derived from embryonic and induced pluripotent stem cells. Recent advances in stem cell technology, especially the widespread ava
Externí odkaz:
https://doaj.org/article/13792230b270489392ea6ccef6085339
Autor:
Sayan Ghosh, Ruchi Sharma, Sridhar Bammidi, Victoria Koontz, Mihir Nemani, Meysam Yazdankhah, Katarzyna M. Kedziora, Donna Beer Stolz, Callen T. Wallace, Cheng Yu-Wei, Jonathan Franks, Devika Bose, Peng Shang, Helena M. Ambrosino, James R. Dutton, Zhaohui Geng, Jair Montford, Jiwon Ryu, Dhivyaa Rajasundaram, Stacey Hose, José-Alain Sahel, Rosa Puertollano, Toren Finkel, J. Samuel Zigler, Yuri Sergeev, Simon C. Watkins, Eric S. Goetzman, Deborah A. Ferrington, Miguel Flores-Bellver, Kai Kaarniranta, Akrit Sodhi, Kapil Bharti, James T. Handa, Debasish Sinha
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a crucial role in RPE health via phagocytosis and autophagy, which a
Externí odkaz:
https://doaj.org/article/9a768d2563fb4e4f839cd5a860fabad3
Autor:
Ersin Akinci, Anannya Banga, Katie Tungatt, Joanna Segal, Daniel Eberhard, James R Dutton, Jonathan M W Slack
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e82424 (2013)
The three transcription factors, PDX1, NGN3 and MAFA, are very important in pancreatic development. Overexpression of these three factors can reprogram both pancreatic exocrine cells and SOX9-positive cells of the liver into cells resembling pancreat
Externí odkaz:
https://doaj.org/article/27051c64ecc443f49e13212171b063cf
Autor:
James R. Dutton, Deborah A. Ferrington, Kevin J. Viken, Vincent Truong, Blake A. Johnson, Mara C. Ebeling, Zhaohui Geng, Samantha Barkan, Sandra R. Montezuma
Publikováno v:
SLAS Technol
Derivation and differentiation of human induced pluripotent stem cells (hiPSCs) provide the opportunity to generate medically important cell types from individual patients and patient populations for research and the development of potential cell the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5a084e75cf47a6fb61f410c12cdd21
https://doi.org/10.1177/2472630320972110
https://doi.org/10.1177/2472630320972110
Autor:
Kailey Carrabre, Patrick J. Walsh, James R. Dutton, Nandadevi Patil, Nicolas S. Lavoie, Eric G. Holmberg, Ann M. Parr
Publikováno v:
Journal of Neurotrauma. 38:777-788
Chronic spinal cord injury (SCI) is a devastating medical condition. In the acute phase after injury, there is cell loss resulting in chronic axonal damage and loss of sensory and motor function including loss of oligodendrocytes that results in demy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40a4b2a53ef1dececabc99f2fef1129
https://doi.org/10.1089/neu.2020.7009
https://doi.org/10.1089/neu.2020.7009
Autor:
Peter A. Santi, Walter C. Low, Aleta R. Steevens, Yun You, James R. Dutton, Matthew W. Griesbach
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2021)
This research is the first to produce induced pluripotent stem cell-derived inner ear sensory neurons in the Neurog1+/− heterozygote mouse using blastocyst complementation. Additionally, this approach corrected non-sensory deficits associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2adc5378a15a5ed83b4006518022b0f9
https://doaj.org/article/52f702c5d50c40be8ec82d0efb64cfa6
https://doaj.org/article/52f702c5d50c40be8ec82d0efb64cfa6
Autor:
Dino Terzic, Jacob R. Maxon, Leah Krevitt, Christina Dibartolomeo, Tarini Goyal, Walter C. Low, James R. Dutton, Ann M. Parr M.D., Ph.D.
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Several neurological disorders, such as multiple sclerosis, the leukodystrophies, and traumatic injury, result in loss of myelin in the central nervous system (CNS). These disorders may benefit from cell-based therapies that prevent further demyelina
Externí odkaz:
https://doaj.org/article/d7c5c91fb803473f831b80211b52e1ae
Autor:
James R. Dutton, Vincent Truong, Walter C. Low, Patrick J. Walsh, Sushmita Nayak, Marietta Saldías Montivero, Ann M. Parr
Publikováno v:
Stem Cells (Dayton, Ohio)
Differentiation of human pluripotent stem cells (hPSCs) into ectoderm provides neurons and glia useful for research, disease modeling, drug discovery, and potential cell therapies. In current protocols, hPSCs are traditionally differentiated into an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ef02c12a1569f9cac36b7735362ede
https://doi.org/10.1002/stem.3260
https://doi.org/10.1002/stem.3260
Testing Mitochondrial-Targeted Drugs in iPSC-RPE from Patients with Age-Related Macular Degeneration
Autor:
Mara C. Ebeling, Zhaohui Geng, Madilyn R. Stahl, Rebecca J. Kapphahn, Heidi Roehrich, Sandra R. Montezuma, Deborah A. Ferrington, James R. Dutton
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 15, Iss 62, p 62 (2022)
Pharmaceuticals; Volume 15; Issue 1; Pages: 62
Pharmaceuticals, Vol 15, Iss 62, p 62 (2022)
Pharmaceuticals; Volume 15; Issue 1; Pages: 62
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. No universally effective treatments exist for atrophic or “dry” AMD, which results from loss of the retinal pigment epithelium (RPE) and photoreceptors and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3afa6759fe16426fd86f5f249aed7c
http://europepmc.org/articles/PMC8781759
http://europepmc.org/articles/PMC8781759