Zobrazeno 1 - 10
of 241
pro vyhledávání: '"James R Davie"'
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63189 (2013)
Mitogen- and stress-activated protein kinases 1 and 2 (MSK1 and MSK2), activated downstream of the ERK- and p38-mitogen-activated protein kinase pathways are involved in cell survival, proliferation and differentiation. Following mitogenic or stress
Externí odkaz:
https://doaj.org/article/d4c175a512674a95b3f3613d41c29bcb
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68742 (2013)
Many studies have established gene expression-based prognostic signatures for lung cancer. All of these signatures were built from training data sets by learning the correlation of gene expression with the patients' survival time. They require all ne
Externí odkaz:
https://doaj.org/article/66ea1e86e1c345c6a766e9f643e87270
Autor:
Isaac K Sundar, Sangwoon Chung, Jae-Woong Hwang, John D Lapek, Michael Bulger, Alan E Friedman, Hongwei Yao, James R Davie, Irfan Rahman
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31378 (2012)
Cigarette smoke (CS) causes sustained lung inflammation, which is an important event in the pathogenesis of chronic obstructive pulmonary disease (COPD). We have previously reported that IKKα (I kappaB kinase alpha) plays a key role in CS-induced pr
Externí odkaz:
https://doaj.org/article/e2ab3d9c2489436b94b403cc90110dd5
Autor:
Parisa Dashti, Eric A. Lewallen, Jonathan A.R. Gordon, Martin A. Montecino, Johannes P.T.M. van Leeuwen, Gary S. Stein, Bram C.J. van der Eerden, James R. Davie, Andre J. van Wijnen
Publikováno v:
Bone Reports, Vol 19, Iss , Pp 101704- (2023)
Osteogenic differentiation of mesenchymal cells is controlled by epigenetic enzymes that regulate post-translational modifications of histones. Compared to acetyl or methyltransferases, the physiological functions of protein arginine methyltransferas
Externí odkaz:
https://doaj.org/article/782923f9b7f54150befe4cda6e4e94a7
Autor:
Prasoon Agarwal, Brandy A. Wicklow, Allison B. Dart, Nikho A. Hizon, Elizabeth A.C. Sellers, Jonathan M. McGavock, Charlotte P. J. Talbot, Mario A. Fonseca, Wayne Xu, James R. Davie, Meaghan J. Jones, Animesh Acharjee, Vernon W. Dolinsky
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
ObjectiveRates of type 2 diabetes (T2D) among adolescents are on the rise. Epigenetic changes could be associated with the metabolic alterations in adolescents with T2D.MethodsWe performed a cross sectional integrated analysis of DNA methylation data
Externí odkaz:
https://doaj.org/article/ed82741761704a319291c6943fd6eae0
Autor:
Tasnim H. Beacon, James R. Davie
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8287 (2023)
The chicken genome is one-third the size of the human genome and has a similarity of sixty percent when it comes to gene content. Harboring similar genome sequences, chickens’ gene arrangement is closer to the human genomic organization than it is
Externí odkaz:
https://doaj.org/article/f28f289b0c4c497dafbfce545ebad44c
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15643 (2022)
Methyl CpG binding protein 2 (MeCP2) is an epigenetic reader that binds to methylated CpG dinucleotides and regulates gene transcription. Mecp2/MECP2 gene has 4 exons, encoding for protein isoforms MeCP2E1 and MeCP2E2. MeCP2 plays key roles in neurod
Externí odkaz:
https://doaj.org/article/4581e0d53b7f4bd6b6136ef1ee4e1f07
Publikováno v:
Cells, Vol 11, Iss 18, p 2830 (2022)
A subset of expressed genes is associated with a broad H3K4me3 (histone H3 trimethylated at lysine 4) domain that extends throughout the gene body. Genes marked in this way in normal cells are involved in cell-identity and tumor-suppressor activities
Externí odkaz:
https://doaj.org/article/d7625b9e31ab4725b4f8683e38ee7919
Autor:
Narges Fatemiyan, James R. Davie
Publikováno v:
Genome.
H4K20me1 (histone H4 monomethylated at lysine 20) generally has a broad distribution along genes and has been reported to be associated with expressed and repressed genes. In contrast, H3K4me3 (histone H3 trimethylated at lysine 4) is positioned as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::225ba1e9dd03a8a19c8c9fb235c0c53d
https://doi.org/10.1139/gen-2023-0011
https://doi.org/10.1139/gen-2023-0011
Autor:
Tasnim H. Beacon, James R. Davie
Publikováno v:
Cells, Vol 10, Iss 6, p 1354 (2021)
The chicken erythrocyte model system has been valuable to the study of chromatin structure and function, specifically for genes involved in oxygen transport and the innate immune response. Several seminal features of transcriptionally active chromati
Externí odkaz:
https://doaj.org/article/83d36ba3d284417fb6ea65bcc584612c