Zobrazeno 1 - 10
of 41
pro vyhledávání: '"James R Damewood"'
Publikováno v:
Journal of Toxicology, Vol 2012 (2012)
While phospholipidosis is thought to be an adaptive response to chemical challenge, many phospholipogenic compounds are known to display adverse effects in preclinical species and humans. To investigate the link between phospholipogenic administratio
Externí odkaz:
https://doaj.org/article/f676128cca8c41b991a7bd012add5b18
Autor:
Pushkor Mukerji, Alexander D Kopatsis, Jian Ping Lai, Richard E Hurteau, Alvin Ibarra, Arthur C. Ouwehand, Supaporn Suwannakham, Sofia D. Forssten, James R Damewood, Robert DiCosimo, Zachary C Baer, Yvonne P Dragan, Brian Michael Roesch, Oliver Hasselwander, Mario L Marquez, Kristin Ruebling-Jass, Steven Cary Rothman, Kirsti Tiihonen, Jessica Caverly Rae, Qiong Cheng, Zheng You
Publikováno v:
International journal of food sciences and nutrition. 68(7)
The aim was to develop novel fibres by enzymatic synthesis, to determine their total dietary fibre by AOAC method 2009.01 and to estimate their potential digestibility and assess their digestibility in vivo using glycaemic and insulinaemic responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baa440be24f827a2f68110de080208f
https://pubmed.ncbi.nlm.nih.gov/28276900
https://pubmed.ncbi.nlm.nih.gov/28276900
Autor:
Linda M. Pullan, Jeffrey M. Goldstein, James R. Damewood, Paul F. Jackson, Jeffrey A. McKinney, Timothy Davenport, Gregory G. Harris, Laura Garcia, Margaret G. Melville, Marc J. Chapdelaine
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:3097-3100
A series of 4-arylbenz[b]azepine analogs were prepared and shown to act as antagonists at the strychnine-insensitive glycine receptor. The heteroaryl substituted benz[b]azepine derivative 11 also showed excellent in vivo activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59678d848e45b17ab696e2481e0e42ae
https://doi.org/10.1016/0960-894x(95)00544-0
https://doi.org/10.1016/0960-894x(95)00544-0
Publikováno v:
Journal of Medicinal Chemistry. 38:86-97
A novel series of human leukocyte elastase (HLE) inhibitors containing the beta-carbolinone ring system are reported. The design of these trifluoromethyl ketone-based inhibitors used a combination of structural information obtained from X-ray crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5b5270d7b6f9aa16b4cbc7ce81b5ba
https://doi.org/10.1021/jm00001a014
https://doi.org/10.1021/jm00001a014
Publikováno v:
Journal of Toxicology
Journal of Toxicology, Vol 2012 (2012)
Journal of Toxicology, Vol 2012 (2012)
While phospholipidosis is thought to be an adaptive response to chemical challenge, many phospholipogenic compounds are known to display adverse effects in preclinical species and humans. To investigate the link between phospholipogenic administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b980f33464daea4b07f5fe7bd31306ea
http://europepmc.org/articles/PMC3382391
http://europepmc.org/articles/PMC3382391
Autor:
Timothy Davenport, Paul F. Jackson, Gregory G. Harris, Laura Garcia, Jeffrey A. McKinney, James R. Damewood, Linda M. Pullan, Marc J. Chapdelaine, Margaret G. Melville, Jeffrey M. Goldstein
Publikováno v:
ChemInform. 27
A series of 4-arylbenz[b]azepine analogs were prepared and shown to act as antagonists at the strychnine-insensitive glycine receptor. The heteroaryl substituted benz[b]azepine derivative 11 also showed excellent in vivo activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eca26a5b5c511165119a61f05f46422a
https://doi.org/10.1002/chin.199615188
https://doi.org/10.1002/chin.199615188
Publikováno v:
Journal of chemical information and modeling. 50(7)
NovoFLAP is a computer-aided de novo design tool that generates medicinally relevant ideas for ligand-based projects. The approach combines an evolutionary algorithm (EA-Inventor) with a powerful ligand-based scoring function that uses both molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20233da8d0cde79edd7b0a79631854b9
https://pubmed.ncbi.nlm.nih.gov/20586434
https://pubmed.ncbi.nlm.nih.gov/20586434
Autor:
Jianwei Liu, Jennifer R. Krumrine, Bernstein Peter Robert, Nugiel David, Daniel Hill, Cynthia D. Sobotka-Briner, Anna Zacco, M. Edward Pierson, James R. Damewood
Publikováno v:
Journal of medicinal chemistry. 53(4)
We describe herein the discovery of novel, de novo designed, 5-HT(1B) receptor antagonists that lack a basic moiety and that provide improved hERG and in vitro phospholipidosis profiles. We used a known 5-HT(1B) antagonist template as our starting po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8626434df01fa83289d48300b27136f
https://pubmed.ncbi.nlm.nih.gov/20088516
https://pubmed.ncbi.nlm.nih.gov/20088516
Autor:
William S. Redfern, James R. Damewood, Russell Bialecki, M. Elizabeth Bell, Jean-Pierre Valentin, Alison Easter, Matthew J. Winter, Carlos Fonck
Publikováno v:
Drug discovery today. 14(17-18)
Assessment of seizure risk traditionally occurs late in the drug discovery process using low-throughput, resource intensive in vivo assays. Such approaches do not allow sufficient time to mitigate risk by influencing chemical design. Early identifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4999bda920cc8f60ef5cebc81add5c6c
https://pubmed.ncbi.nlm.nih.gov/19545644
https://pubmed.ncbi.nlm.nih.gov/19545644
Autor:
James R. Damewood
Publikováno v:
Reviews in Computational Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::451a9f9e45961f8feb9d0f83c909698b
https://doi.org/10.1002/9780470125861.ch1
https://doi.org/10.1002/9780470125861.ch1
