Zobrazeno 1 - 10
of 62
pro vyhledávání: '"James R Bunzow"'
RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain
Autor:
Brooks G Robinson, Xintong Cai, Jiexin Wang, James R Bunzow, John T Williams, Pascal S Kaeser
Publikováno v:
eLife, Vol 8 (2019)
Action potentials trigger neurotransmitter release at active zones, specialized release sites in axons. Many neurons also secrete neurotransmitters or neuromodulators from their somata and dendrites. However, it is unclear whether somatodendritic rel
Externí odkaz:
https://doaj.org/article/d43753a1786341ae86e468de7555a641
Publikováno v:
eLife, Vol 7 (2018)
Phosphorylation of the μ-opioid receptor (MOR) is known as a key step in desensitization and internalization but the role in the development of long-term tolerance at the cellular level is not known. Viral expression of wild type (exWT) and mutant M
Externí odkaz:
https://doaj.org/article/f6d691f4144f42ce8c816130d6510b70
Autor:
Stephanie C Gantz, Brooks G Robinson, David C Buck, James R Bunzow, Rachael L Neve, John T Williams, Kim A Neve
Publikováno v:
eLife, Vol 4 (2015)
D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood. By virally express
Externí odkaz:
https://doaj.org/article/8ad20fd828744c2a90d9e5d99be6908d
Autor:
Joseph J. Lebowitz, Aditi Banerjee, Claire Qiao, James R. Bunzow, John T. Williams, Pascal S. Kaeser
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111915- (2023)
Summary: Modes of somatodendritic transmission range from rapid synaptic signaling to protracted regulation over distance. Somatodendritic dopamine secretion in the midbrain leads to D2 receptor-induced modulation of dopamine neurons on the timescale
Externí odkaz:
https://doaj.org/article/ebc7818d6b3c4ade8c5d72abb0722ab2
Autor:
Brooks G. Robinson, James R. Bunzow, Jonathan B. Grimm, Luke D. Lavis, Joshua T. Dudman, Jennifer Brown, Kim A. Neve, John T. Williams
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Dendritic release of dopamine activates dopamine D2 autoreceptors, which are inhibitory G protein-coupled receptors (GPCRs), to decrease the excitability of dopamine neurons. This study used tagged D2 receptors to identify the localization a
Externí odkaz:
https://doaj.org/article/cd52b855e0284c209df9fce0fd4cbae8
Autor:
Susan R. Sesack, John T. Williams, Mason Trinkle, Savas Hetelekides, Judith Joyce Balcita-Pedicino, Brooks G. Robinson, Sue A. Aicher, Santiago De La Torre, James R. Bunzow, Joseph J. Lebowitz
Publikováno v:
Brain Struct Funct
G-Protein coupled D2 autoreceptors expressed on dopamine neurons (D2Rs) inhibit transmitter release and cell firing at axonal endings and somatodendritic compartments. Mechanistic details of somatodendritic dopamine release remain unresolved, partly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182424b56c38689576e9d7e1ccd56bd8
https://doi.org/10.1007/s00429-021-02432-3
https://doi.org/10.1007/s00429-021-02432-3
Autor:
Jospeph J. Lebowitz, James R. Bunzow, Susan R. Sesack, Brooks Robinson, Judith Joyce Balcita-Pedicino, Mason Trinkle, John T. Williams, Sue A. Aicher, Savas Hetelekides
Dopamine neurons use autoregulation for appropriate modulation of goal-directed behaviors, and yet the mechanisms for D2 receptor (D2R)-mediated autoregulation are not fully understood. Electrophysiology suggests close proximity between dopamine rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f73d4ebd117440a9a265bf6d7057995
https://doi.org/10.21203/rs.3.rs-435698/v1
https://doi.org/10.21203/rs.3.rs-435698/v1
G-Protein coupled D2 receptors expressed on dopamine neurons, i.e. D2-autoreceptors (D2Rs), negatively regulate transmitter release and cell firing in axonal terminals and somatodendritic compartments. However, as the membrane distribution of D2Rs at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de4d042b86e75490893e95dd81b8f5e5
https://doi.org/10.21203/rs.3.rs-435162/v1
https://doi.org/10.21203/rs.3.rs-435162/v1