Zobrazeno 1 - 10
of 291
pro vyhledávání: '"James R Bain"'
Autor:
Sharareh Siamakpour-Reihani, Felicia Cao, Jing Lyu, Yi Ren, Andrew B Nixon, Jichun Xie, Amy T Bush, Mark D Starr, James R Bain, Michael J Muehlbauer, Olga Ilkayeva, Virginia Byers Kraus, Janet L Huebner, Nelson J Chao, Anthony D Sung
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0268963 (2022)
Although hematopoietic stem cell transplantation (HCT) is the only curative treatment for acute myeloid leukemia (AML), it is associated with significant treatment related morbidity and mortality. There is great need for predictive biomarkers associa
Externí odkaz:
https://doaj.org/article/7190c06e2b074155b87fa5c45df42191
High heritability of metabolomic profiles in families burdened with premature cardiovascular disease
Autor:
Svati H Shah, Elizabeth R Hauser, James R Bain, Michael J Muehlbauer, Carol Haynes, Robert D Stevens, Brett R Wenner, Z Elaine Dowdy, Christopher B Granger, Geoffrey S Ginsburg, Christopher B Newgard, William E Kraus
Publikováno v:
Molecular Systems Biology, Vol 5, Iss 1, Pp 1-7 (2009)
Abstract Integration of genetic and metabolic profiling holds promise for providing insight into human disease. Coronary artery disease (CAD) is strongly heritable, but the heritability of metabolomic profiles has not been evaluated in humans. We per
Externí odkaz:
https://doaj.org/article/33b76d0f84194249ae833a7b95ee37d9
Autor:
William E Kraus, Deborah M Muoio, Robert Stevens, Damian Craig, James R Bain, Elizabeth Grass, Carol Haynes, Lydia Kwee, Xuejun Qin, Dorothy H Slentz, Deidre Krupp, Michael Muehlbauer, Elizabeth R Hauser, Simon G Gregory, Christopher B Newgard, Svati H Shah
Publikováno v:
PLoS Genetics, Vol 11, Iss 11, p e1005553 (2015)
Levels of certain circulating short-chain dicarboxylacylcarnitine (SCDA), long-chain dicarboxylacylcarnitine (LCDA) and medium chain acylcarnitine (MCA) metabolites are heritable and predict cardiovascular disease (CVD) events. Little is known about
Externí odkaz:
https://doaj.org/article/71d65ad2e8ba483ea543b1b239ab3bdc
Autor:
Bon Jeong Ku, Tae Hoon Kim, Jae Hee Lee, Eric D Buras, Lisa D White, Robert D Stevens, Olga R Ilkayeva, James R Bain, Christopher B Newgard, Francesco J DeMayo, Jae-Wook Jeong
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42915 (2012)
The disruption of cholesterol homeostasis leads to an increase in cholesterol levels which results in the development of cardiovascular disease. Mitogen Inducible Gene 6 (Mig-6) is an immediate early response gene that can be induced by various mitog
Externí odkaz:
https://doaj.org/article/0e6359e405594a9ba2f1da5581cf38fe
Autor:
Kim M Huffman, Leanne M Redman, Lawrence R Landerman, Carl F Pieper, Robert D Stevens, Michael J Muehlbauer, Brett R Wenner, James R Bain, Virginia B Kraus, Christopher B Newgard, Eric Ravussin, William E Kraus
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e28190 (2012)
To determine if caloric restriction (CR) would cause changes in plasma metabolic intermediates in response to a mixed meal, suggestive of changes in the capacity to adapt fuel oxidation to fuel availability or metabolic flexibility, and to determine
Externí odkaz:
https://doaj.org/article/02e6b7fb4190457b8721f0b5c8321b7b
Autor:
Preena Nagpal, Pamela J Plant, Judy Correa, Alexandra Bain, Michiko Takeda, Hiroshi Kawabe, Daniela Rotin, James R Bain, Jane A E Batt
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46427 (2012)
Skeletal muscle atrophy is a consequence of muscle inactivity resulting from denervation, unloading and immobility. It accompanies many chronic disease states and also occurs as a pathophysiologic consequence of normal aging. In all these conditions,
Externí odkaz:
https://doaj.org/article/ab2042ac198344709241ab93e0ccbb95
Autor:
Christine T Ferrara, Ping Wang, Elias Chaibub Neto, Robert D Stevens, James R Bain, Brett R Wenner, Olga R Ilkayeva, Mark P Keller, Daniel A Blasiole, Christina Kendziorski, Brian S Yandell, Christopher B Newgard, Alan D Attie
Publikováno v:
PLoS Genetics, Vol 4, Iss 3, p e1000034 (2008)
Although numerous quantitative trait loci (QTL) influencing disease-related phenotypes have been detected through gene mapping and positional cloning, identification of the individual gene(s) and molecular pathways leading to those phenotypes is ofte
Externí odkaz:
https://doaj.org/article/48e820b028a54bf79bb5efbff00034d9
Autor:
Pinar Gumus Balikcioglu, Catherine Jachthuber Trub, Metin Balikcioglu, Olga Ilkayeva, Phillip J. White, Michael Muehlbauer, James R. Bain, Sarah Armstrong, Michael Freemark
Publikováno v:
Endocrinology, Diabetes & Metabolism, Vol 6, Iss 1, Pp n/a-n/a (2023)
Abstract Objectives Insulin resistance (IR) in adolescents with obesity is associated with a sex‐dependent metabolic ‘signature’ comprising the branched‐chain amino acids (BCAAs), glutamate/glutamine, C3/C5 acylcarnitines and uric acid. Here,
Externí odkaz:
https://doaj.org/article/24ad93a4efbf4bb7b0981e4b904ef0e0
Autor:
Monica E. Bianco, My H. Vu, James R. Bain, Michael J. Muehlbauer, Olga R. Ilkayeva, Denise M. Scholtens, Jami Josefson, William L. Lowe
Publikováno v:
Metabolites, Vol 13, Iss 6, p 749 (2023)
Maternal metabolites influence the size of newborns independently of maternal body mass index (BMI) and glycemia, highlighting the importance of maternal metabolism on offspring outcomes. This study examined associations of maternal metabolites durin
Externí odkaz:
https://doaj.org/article/76c1c5db59fd4e11bde4232cbc0f9be2
Autor:
Brooke Gleason, Alan Kuang, James R. Bain, Michael J. Muehlbauer, Olga R. Ilkayeva, Denise M. Scholtens, William L. Lowe
Publikováno v:
Metabolites, Vol 13, Iss 4, p 505 (2023)
The in utero environment is important for newborn size at birth, which is associated with childhood adiposity. We examined associations between maternal metabolite levels and newborn birthweight, sum of skinfolds (SSF), and cord C-peptide in a multin
Externí odkaz:
https://doaj.org/article/0da6bab1d495420a8195ba97577d59ac